326 zoekresultaten voor “infectious disease” in de Publieke website
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Dyslipidemia, metabolism and autophagy: antigen-independent modulation of T cells in atherosclerosis
Atherosclerosis is the main underlying pathology of cardiovascular disease. Atherosclerosis is caused by an immune response which is directed against (modified) lipoproteins which accumulate in the vessel wall.
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Systems pharmacology of the amyloid cascade
According to the amyloid cascade hypothesis, accumulation of beta-amyloid (Aβ) peptides initiates the pathological cascade in Alzheimer's disease (AD).
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Carel Stolker in de media: 'Brexit houdt wetenschap echt niet tegen'
'Onderschat nooit de verbindende kracht van wetenschappelijk onderzoek en onderwijs.' Dat stelde rector magnificus Carel Stolker in zijn toespraak op de dies, waarbij hij vooral doelde op de naderende Brexit. Een boodschap die veel weerklank vond in de (internationale) media.
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Malaria-onderzoekers van over de hele wereld naar Leiden
Onderzoekers van over de hele wereld komen van 2 tot 4 mei naar Leiden voor een groot malariacongres. Het Leids Universitair Medisch Centrum (LUMC) organiseert aansluitend een tweedaagse workshop over hoe vaccins op een veilige en efficiënte manier in de mens getest kunnen worden.
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Comorbidities, complications and treatment of childhood obesity
Childhood obesity is an increasing health issue. In the first part of this thesis comorbidities in children with obesity were studied, concerning the diagnostic process and dosing regimens.
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Protein arginine methyltransferases as modulators of lipid metabolism and inflammation and the relevance for atherosclerosis
Acute cardiovascular clinical events such as myocardial infarction and cerebral stroke represent the major cause of death in Western societies. These pathologies are primarily resulting from atherosclerosis, a progressive condition characterized by the accumulation of lipids, immune cells, and fibrous…
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Single-cell immune profiling of atherosclerosis: from omics to therapeutics
Acute cardiovascular syndromes, including myocardial infarction or stroke, are the principal cause of death in the Western society. The main underlying pathology of cardiovascular diseases is atherosclerosis, which is caused by the accumulation of lipids and inflammatory cells in the vessel wall, in…
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LLP-studenten aan de slag bij Janssen voor een World Without Disease
Een wereld zonder ziekte: toekomst of illusie? In ieder geval het nastreven waard, vinden ze bij Janssen, dat de mogelijkheden voor zo’n wereld daarom onderzoekt. Studenten van het Leiden Leadership Programme brachten voor het bedrijf enkele dilemma’s in kaart die daarbij een rol kunnen spelen.
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Innovative strategies to clinically characterize the human tear proteome
Transplantation of labial salivary glands to the eyelids for patients with dry eye appears to give excellent results clinically.
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Microengineered Human Blood Vessels For Next Generation Drug Discovery
Heart failure is a major health care problem with high mortality.
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Macrophage activation and cholesterol in atherosclerosis development
Promotores:Th.J.C. van Berkel, M. van Eck
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Small changes for long term impact: optimization of structure kinetic properties: a case of CCR2 antagonists
Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: L.H. Heitman
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Photocleavable activity-based acid glucosylceramidase probes
Lysosomal acid glucosylceramidase (GBA1) is a lysosomal enzyme that degrades glucolipids with its main substrate being glucosylceramide (GlcCer). Defects in the GBA1 gene lead to glycosphingolipidosis Gaucher disease (GD), in which the hydrolysis of GlcCer is impaired and therefore, it accumulates in…
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Modulation of the immune system for treatment of atherosclerosis
Cardiovascular diseases are the primary cause of death in the world with atherosclerosis as primary underlying cause.
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Afrika heroverwogen
Wie Westerse media volgt, denkt al snel aan 'Afrika' als het herkomstoord van wanhopige migranten, continent van honger en ziektes, broedplaats voor internationaal terrorisme. Wie een breder beeld wil hebben, kan terecht bij de Leidse Afrikanisten. Juist door hun nauwe banden met Afrikaanse partners…
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Systematic investigations into the role of ceramide subclass composition on lipid organization and skin barrier
The lipids in the uppermost layer of the skin, the stratum corneum (SC), play an important role in the skin barrier function. The three main SC lipid classes are ceramides (CER), cholesterol and free fatty acids.
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Distance-based analysis of dynamical systems and time series by optimal transport
Promotor: S.M. Verduyn Lunel
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Maria Yazdanbakhsh ontvangt Spinozapremie voor onderzoek naar vaccins
De Leidse hoogleraar Maria Yazdanbakhsh (Cellulaire immunologie van parasitaire infecties) ontvangt dit jaar de prestigieuze NWO Spinozapremie. Deze, in vele opzichten, grensoverschrijdende wetenschapper draagt met haar onderzoek bij aan betere vaccins tegen parasitaire infecties en aan betere geneesmiddelen…
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Wat Nu: Afgestudeerde Bachelor Studenten over hun Toekomstplannen
Na drie (of vier) lange jaren studeren, nemen elk jaar weer veel van onze Bachelorstudenten afscheid om de wijde wereld in te gaan. Waar komen ze terecht? En wat gaan ze het meeste missen aan onze mooie hofstad? De komende weken delen we de verhalen van zes studenten van Bestuurskunde en Leiden University…
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Global metabolomics and lipidomics approaches to probe virus-host interactions
The outbreaks of AIDS and COVID-19 showed clearly how infectious viruses can influence people’s lives. Investigating the changes in the host metabolism may provide a paradigm shift to consider immune-metabolic interactions as therapeutic targets.
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Lessons from Rare Diseases
Promotie
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Cholesterol metabolism and hematopoiesis interaction in atherothrombosis
Cardiovascular disease is the leading cause of death worldwide.
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Bioorthogonal Antigens as Tool for Investigation of Antigen Processing and Presentation
In order to be able to develop effective medicine and treatments to prevent or cure autoimmune diseases or cancer we need to understand the mechanisms how they arise and what drives their course.Unravelling the fundamental molecular mechanisms influencing the onset and course of diseases such as allergies,…
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Analytical chemistry and biochemistry of glycosphingolipids: new developments and insights
Advanced mass spectrometry of glycosphingolipids takes the central stage in this thesis. Investigations focus on characterization of glycosphingolipid metabolism in health and disease with emphasis to the detection and accurate quantitation of known and so far unknown glycosphingolipids and closely…
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Reducing the chronic disease burden in China
Promotie
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Synthesis and application of glycans unique to S. Mansoni
Schistosomiasis is an acute and chronic disease caused by blood dwelling parasitic trematodes of the genus Schistosoma, and it is classified as the second most socioeconomically devastating parasitic disease, second only to malaria.
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Development of kinase inhibitors and activity-based probes
Promotor: H.S. Overkleeft, J. Neefjes, Co-promotor: M. van der Stelt
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Vernieuwend Leids onderzoek ontvangt NWO-subsidie
Hoogleraar Annemarie Meijer en dr. Sander Wezenberg ontvingen op 24 januari een NWO-subsidie voor hun onderzoek. De subsidie is toegekend binnen het Open Competitie ENW-M-programma en is bedoeld voor vernieuwende onderzoeksgebieden die de basis kunnen zijn voor onderzoeksthema’s van de toekomst.
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Activity-based protein profiling of diacylglycerol lipases
Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt
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The synthesis of chemical tools for studying sphingolipid metabolism
Sphingolipids are important membrane compounds with a variety of functions. In mammalian cells, different enzymes are involved in the metabolism of sphingolipids, but interruption of this metabolism process leads to different diseases.
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Discovery of FLT3 inhibitors for the treatment of acute myeloid leukemia
The disease acute myeloid leukemia (AML) is characterized by fast progression and low survival rates.
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Data-Driven Machine Learning and Optimization Pipelines for Real- World Applications
Machine Learning is becoming a more and more substantial technology for industry.
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Multimodality imaging in patients with valvular heart disease and systemic diseases
Promotie
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Chemical tools to study the cannabinoid receptor type 2
The cannabinoid receptor type 2 (CB2R) is associated with several inflammatory diseases with an unmet medical need (e.g. Alzheimers, multiple sclerosis, reumatoid arthritis). Development of new chemical biology strategies to study this protein is essential to aid future development of drugs for these…
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Identification of Therapeutic Targets and Antisense Oligonucleotide Mediated Exon Skipping Based Therapies in Arthritis
Promotor: G.J.B. van Ommen
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Microvasculature in Microfluidics: matching complexity with compatibility
In vitro disease models play a fundamental role in drug research. They enable the systemic identification and validation of disease mechanisms and the discovery of possible drug targets. However, more than often, drug candidates that are identified in vitro fail in the later clinical stages of drug…
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Elucidating the pathogenesis underlying bicuspid aortic valve disease using new disease models
Promotie
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CD8+ T-cells in atherosclerosis: mechanistic studies revealing a protective role in the plaque microenvironment
Atherosclerosis is the most important underlying process that drives cardiovascular disease, and is characterized by an accumulation of cholesterol which triggers an inflammatory response in the vessel wall.
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Cholesterol metabolism in mouse models of atherosclerosis and adrenal steroidogenesis
Cholesterol influences many pathways, including serving as precursor for adrenal steroidogenesis. Imbalance of cholesterol levels has been implicated in several diseases including cardiovascular diseases and its underlying pathology, atherosclerosis.
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Nieuwe inzichten in mycobacteriële infecties met NWO-beurs
Waarom zijn mycobacteriën zulke succesvolle ziekteverwekkers? En zijn er verdedigingsmechanismen in het lichaam die helpen een infectie iets te verminderen? Om dit te achterhalen, heeft Annemarie Meijer de NWO Open competitie ENW-XL-beurs toegekend gekregen. Ze gaat niet alleen aan de slag. Aan het…
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Human skin equivalents for atopic dermatitis: investigating the role of filaggrin in the skin barrier
Promotor: Prof.dr. J.A. Bouwstra, Co-promotor: A. El Ghalbzouri
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A pharmacognostic study of Vernonia guineensis Benth. (Asteraceae): bioactivity, safety, and phytochemical analysis
Promotor: Prof.dr. R. Verpoorte, Co-Promotor: Dr. Young Hae Choi
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Sensing Transport
Solute carrier (SLC) transporters are a large and diverse class of relatively understudied transmembrane proteins.
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Maximal Systolic Acceleration in atherosclerotic vascular disease
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Predicting Outcomes in Patients with Kidney Disease
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Adult weight change and cardiometabolic disease
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Conceptualisation of disease resolution in rheumathoid arthritis
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Cardiovascular disease burden in thoracic aortopathy
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Inflammatory Bowel Disease in Older Patients
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Wiskundig model helpt ontstaan van wervels en ribben te verklaren
Leidse wiskundig biologen hebben een model ontwikkeld dat helpt verklaren hoe onder meer de ruggengraat en de wervels ontstaan in de embryonale ontwikkeling. Hetzelfde proces, maar dan andersom, speelt een sleutelrol bij de uitzaaiing van kanker. Publicatie in iScience.