Streptomyces present a valuable platform for natural product discovery. Lugdunomycin is a novel angucycline-derived polyketide from Streptomyces sp QL37, with unprecedented skeleton and antimicrobial activity.

Promotores: Prof.dr. E.A.L. Biessen, Prof.dr. T.J.C. van Berkel

Glucocorticoids (GCs) are widely prescribed as anti-inflammatory drugs due to their well-established immunosuppressive effects.

Promotor: Johan Kuiper, Co-promotor: Saskia C.A. de Jager

In this thesis, topics relating to the optimization of high-throughput pipelines used for imaging are discussed. In particular, different levels of implementation, i.e., conceptual, software, and hardware, are discussed and the thesis outlines how advances on each level need to be made to make gains…

The thesis is about the study of shell evolution of the Hydrocenidae of the genus Georissa. This thesis started with a general overview on the evolutionary process of animals due to ecological changes.

Patterned detectors are an existing technology that can be found in almost all color cameras.

Streptomyces are prolific producers of enzymes and secondary metabolites, including more than 50% of all clinical antibiotics. This makes them highly attractive for medical, biotechnological, and industrial purposes.

The PID-directed shift in PIN polarity has been broadly accepted as one of the essential mechanisms for the regulation of auxin transport polarity.

Drie docenten van Geesteswetenschappen ontvingen dit jaar de Senior Kwalificatie Onderwijs (SKO). Docent Hossam Ahmed is een van hen. Wat maakt onderwijs volgens hem goed?

In the last decades, activity-based protein profiling (ABPP) has emerged as a powerful chemical tool that may aid the ever-challenging drug discovery process.

Promotor: Prof.dr. H.P. Spaink, Co-promotor: Dr. B.E. Snaar

Synthetic hydrogels that mimic the natural extracellular matrix in the biophysical and biochemical cues it provides to cells are in high demand, however the cell phenotypes as they are observed in vivo in numerous cases have yet to be attained.

Within the Research Training Group 2304 “Byzantium and the Euro-Mediterranean Cultures of War. Exchange, Differentiation and Reception”, which is financed by the DFG (German Research Foundation), there are at the Johannes Gutenberg University of Mainz 2 positions for doctoral research associates (pay…

Within the Research Training Group “Byzantium and the Euro-Mediterranean Cultures of War. Exchange, Differentiation and Reception” at the Johannes Gutenberg University of Mainz 1 postdoctoral position is to be filled by 1 April 2023, for a period of up to 4,5 years. Deadline: 5 January 2023.

Within the Research Training Group 2304 “Byzantium and the Euro-Mediterranean Cultures of War. Exchange, Differentiation and Reception”, which is financed by the DFG (German Research Foundation), there are at the Johannes Gutenberg University of Mainz 6 positions for doctoral research associates (pay…

GLOBOX is a spatially differentiated multimedia fate, exposure and effect model. It is used for the calculation of spatially differentiated LCA characterisation factors on a global scale.

Leidse wetenschappers zijn hoofdaanvrager van vijf projecten die door NWO zijn gehonoreerd met een ENW-Groot-subsidie tot 3 miljoen euro in het domein Exacte en Natuurwetenschappen. Daarnaast zijn Leidenaren betrokken bij diverse andere gehonoreerde projecten.