Promotor: P.D. Grünwald

Lipid signaling is an essential biological event/process in a plethora of pathophysiological conditions. The underlying idea of this thesis is that many of the roles and the complex interplay of the individual signaling lipids in inflammatory processes and related conditions in health and disease is…

This thesis explores different avenues to develop insurmountable antagonists for CC Chemokine Receptors, such as CCR1, CCR2 and CCR5.

This thesis investigates how non-genetic factors, such as inflammation and concomitant medication, impact hepatic drug metabolism and subsequent drug metabolizing phenotype predictions.

De discussie over inzetbaarheid van afgestudeerden in het hoger onderwijs bestaat al een aantal jaren. Toch staan ​​universiteiten nog steeds voor de uitdaging om afgestudeerden te leveren die aan de verwachtingen van het bedrijfsleven kunnen voldoen.

Hoewel spreekvaardigheidonderwijs internationaal wordt beschouwd als essentieel voor het bevorderen van communicatieve vaardigheden en kritisch denken, is dit domein aanzienlijk minder onderzocht dan lees- en schrijfvaardigheid. Dit onderzoeksproject had als overkoepelend doel zicht te krijgen op werkende…

Deelproject van

Graduation MIRD Class of 2024: 'The world is better off with students like this'

The present thesis focuses on the pharmacological concept of drug-target interaction, which dates back to the beginning of modern pharmacology.

This thesis explored the molecular pharmacological mechanisms of targeting CB2R via investigation of novel drug discovery concepts such as target binding kinetics, allosteric modulation and biased signaling.

Despite the fact that gold nanoparticles (GNPs) are one of the most studied nanoparticles, there is still a necessity for new approaches allowing for effective protective coating to enable wider use of GNPs in biomedical applications.

Whilst government’s ability to design ‘context-specific’ regional innovation policy is generally assumed to depend on the region’s decision-making power, the aim of this study is to investigate how regional government matters. In order to open up the black box of policy design, the study develops a…

While ecosystems have concrete benefits for human society, these benefits are typically overlooked in decision-making.

Promotor: Jelle S. Kaastra Co-promotor: Jelle de Plaa

Promotors: Prof.dr. T.H.W. Bäck, Prof.dr. B. Sendhoff (Technische Universität Darmstadt)

Catalysis is of extreme relevance in the production of everyday materials and plays a central role in many aspects of our life.

It has now been well established that shocks and turbulent motions in the intra-cluster medium (ICM) generated through cluster mergers can produce large-scale synchrotron emission.

Promotores: Prof.dr. W.J.G.M. Peijnenburg & Dr. M.G. Vijver

Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: L.H. Heitman

Promotor: J. Aarts

Bekijk de oratie van het Global Transoformations and Governance Challenges Programma. De toespraak, getiteld ‘Governing a (Better) Global World’, werd in februari 2022 gehouden door Prof. Dr. Jan Aart Scholte.

Promotor: G.J.B. van Ommen

Promotor: A.P. IJzerman Co-promotor: L.H. Heitman

Promotor: Prof.dr. H.J.M de Groot, Co-Promotor: A. Alia

Less than 1 in 10 drug candidates that enter phase 1 clinical trials actually gets approved for human use.

Promotie

Lezing, SMILE - Reeks Experimentele Taalkunde

The thesis explores how interstellar chemistry evolves as a function of time and changing physical architectures during the formation of stars.

This thesis deals with the use of sound in interactions in the context of participatory systems and data sonification. We investigate an interactive environment where participants perceive information of the data through sound elements.

The experiences of ethnic ‘Other’ females have – until recently – been widely overlooked in the study of sport. There continues to be a need to produce critical scholarship about ethnic 'Other' girls and women in sport and physical culture, in order to represent their complex, multifarious and dynamic…

A Josephson junction is a device where a thin insulating barrier or a nanostructure is placed between two superconducting leads. Such a junction is essential to superconducting qubits that store quantum information due to its anharmonic spectrum.

Neuraminidases are enzymes that cleave glycosidic linkages of sialic acid. These enzymes are involved in influenza infections as well as in many cellular processes in mammals and micro-organisms.

This Thesis shows discoveries in non-linear astrochemical kinetics as well as a deeper analysis of dark clouds chemistry.

In deep reinforcement learning, searching and learning techniques are two important components. They can be used independently and in combination to deal with different problems in AI, and have achieved impressive results in game playing and robotics. These results have inspired research into artificial…

Cytotoxic T-cells (CTLs) are involved in the clearance of viruses and killing of tumor cells.

The largest structures in the Universe are clusters of galaxies. Each can contain hundreds to thousands of galaxies.

Promotor: G. A. van der Marel, Co-promotor: D. V. Filippov

Promotor: Prof.dr. A.G.G.M. Tielens, Prof.dr. C. Dominik (UvA)

Promotor: M.T.M. Koper, Co-Promotor: L.B.F. Juurlink

Sheltering is an immediate human need and determines well-being andhealth.

The European Council and the European Commission have a similar role in agenda setting. Both place issues on the EU agenda. However, these institutions have distinct designs. They have different political attributes (the European Council has considerably more political authority) and information-processing…

The aim of this thesis was to study phage infection in Streptomyces, focused on cell wall-deficient cells. Bacteriophages (or phages in short) attach to the cell wall of bacteria after which they replicate and lyse the host cell.

Radio jets are important to the evoultion of galaxies. However, it is still not fully understood how a radio jet can be triggered.

Software development is a complex process. It is important that software products become stable and maintainable assets.

This thesis focuses on amyloid proteins, a class of proteins that convert into amyloid fibrils.

Quantum computers are a proposed fundamentally new type of computer. They aim to perform some computations much faster than previously possible by exploiting phenomena at the quantum scale, called superposition and entanglement.

In this thesis, I investigated the neurogenetic properties of Neotropical bat species. Bats represent the second largest mammalian order (Chiroptera) in the world, with Neotropical bats constituting about 13% of the total number of bat species.

This thesis investigates the evolution and fate of gaseous exoplanets, which are continuously shaped by stellar activity across both short and long timescales.

Lezing

Studying the impact of urbanisation on the respiratory health of past Dutch populations (1200-1850 CE).