670 zoekresultaten voor “brexit cancer metastasis” in de Publieke website
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Cell-autonomous and host-dependent CXCR4 signaling in cancer metastasis: insights from a zebrafish xenograft model
Promotor: A.H. Meijer, Co-promotor: B.E. Snaar-Jagalska
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Mechanisms of Ewing sarcoma metastasis
Promotor: T. Schmidt, Co-Promotor: B.E. Snaar-Jagalska
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Image-based phenotypic screening for breast cancer metastasis drug target discovery
The main aim of this thesis was to unravel the signaling and regulatory networks that drive tumor cell migration during breast cancer metastasis.
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multifaceted roles of Grainyhead-like transcription factor-2 in breast cancer
Breast cancer is the most common cancer in women worldwide. Metastasis, the process by which cancer cells spread to other parts of the body, makes treatments less effective. It is important to unravel the mechanism of metastasis.
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Identification of novel targets in prostate cancer progression
Promotor: B. van de Water, Co-promotor: E.H.J. Danen
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xenograft model: identification of novel mechanisms driving prostate cancer metastasis
Prostate cancer (PCa) is one of the most prevalent cancer in males.
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Novel regulators of prostate cancer stem cells and tumor aggressiveness
Promotor: R.C.M. Pelger Co-Promotor: G. van der Pluijm
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RNA splicing in breast cancer progression
In this thesis, we aimed to better understand the underlying mechanisms involved in TNBC progression and metastasis formation and discover new targets to reduce breast cancer related deaths.
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Pulling the strings on anti-cancer immunity
Promotores: J. Jonkers, K.E. de Visser
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Brexit-procedure in kaart
Het Verenigde Koninkrijk heeft gekozen voor een Brexit. Wat zijn de juridische spelregels bij een uittreding uit de EU? Hoogleraar Christa Tobler bracht het in kaart.
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Brexit
Ben je een Britse burger die aan de Universiteit Leiden studeert of werkt? Of ben je een Leidse student die in het Verenigd Koninkrijk studeert of wil gaan studeren? Hier vind je meer informatie over de gevolgen van Brexit voor studenten en medewerkers.
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Exploring Grainyhead-like 2 target genes in breast cancer
The objective of this study was to investigate the expression and function of GRHL2 in different breast cancer subtypes.
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PI3K signaling and adherens junctions in invasive lobular breast cancer
Invasive lobular carcinoma (ILC) is the second most common type of breast cancer.
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Hans Vollaard over een ‘brexit’
Wat de uitslag ook wordt op 23 juni 2016, de kans is groot dat er daarna weer een Brits referendum over Europa nodig is. Aldus de Leidse politicoloog Hans Vollaard
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Discovery of BUB1 kinase inhibitors for the treatment of cancer
The spindle-assembly checkpoint (SAC) is a safety mechanism which secures accurate chromosome segregation during mitosis.
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BRCA1-associated breast cancer: finding new weapons for an old villain
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Development of novel anti-cancer strategies utilizing the zebrafish xenograft model
In this thesis, we will utilize embryonic zebrafish tumour models to understand the interaction between engrafted human cancer cells and macrophages from the host, test drug administration modalities and anti-cancer efficacies of newly-developed PDT and PACT compounds, and test a light-triggered liposomal…
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De mondiale Brexit: de internationale consequenties van de terugtrekking van het VK uit de EU
Het beëindigen van het zevenenveertig jarige lidmaatschap van het Verenigd Koninkrijk (VK) met de Europese Unie (EU) heeft de relaties tussen de twee fundamenteel veranderd. Na jaren van tumultueuze onderhandelingen bepaalt internationaal recht nu weer de VK’s relatie met de EU. Dit heeft geresulteerd…
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Cancer chess: molecular insights into PARP inhibitor resistance
The clinical potential of applying synthetic lethality to cancer treatment is famously demonstrated by the BRCA1/PARP1 paradigm: a tumor specific defect in BRCA1 – a component of the DNA double-strand break (DSB) repair pathway homologous recombination (HR) – results in a remarkable sensitivity to PARP1…
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Patient-derived models of breast cancer: a breakthrough story of the duct
To improve treatment of breast cancer patients it is important to understand all stages of breast cancer from initiation to in situ disease and progression to invasive disease. In this thesis we use intraductal injections of patient derived tissue to model ductal carcinoma in situ and invasive breast…
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Precision modeling of breast cancer in the CRISPR era
The molecular mechanisms that instigate a healthy cell to become malignant are fueled by (epi)genetic alterations in so-called driver genes.
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Orientational Order and Confinement in Biological Tissues
This thesis investigates how cell shape and collective behavior influence the dynamics and structure of biological tissues, which are crucial for understanding processes like embryonic development, tissue regeneration, and metastasis.
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genes driving tumorigenesis and therapy resistance in human breast cancer
To improve cancer treatments, personalized medicine approaches have aimed to identify exactly which mutations are driving tumor development in a given patient and specifically target these mutations using precision therapies.
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Exploring the mechanisms of metastatic onset for novel treatment strategies
This thesis represents a comprehensive investigation into the control of cancer stemness and metastatic initiation using a combination of advanced zebrafish xenograft models and in vitro assays.
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Liposome-based synthetic long peptide vaccines for cancer immunotherapy
Promotores: Wim Jiskoot; Ferry Ossendorp
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The diverse roles of integrin α3β1 in cancer: Lessons learned from skin and breast carcinogenesis
In this thesis, we aim to shed light on the diverse and often opposing roles of integrin α3β1 in cancer.
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Disrupting the transcriptional machinery to combat triple-negative breast cancer
Triple-negative breast cancer (TNBC) is a subtype of breast cancer characterized by limited treatment options and unfavorable clinical outcomes. Therefore, the research described in this thesis focused on the exploration of novel targeted therapies for TNBC.
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Uncovering vulnerabilities in triple-negative breast cancer
Triple-negative breast cancer (TNBC) constitutes a small subtype (~15%) of breast cancer, but causes the majority of breast cancer-related deaths.
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Targeted Therapy for Triple-Negative Breast Cancer
The research described in this thesis focused on identifying novel drug targets and synergistic combinations for triple-negative breast cancer (TNBC), a virulent subtype of breast cancer with a dismal prognosis and limited therapeutic options.
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Systemic Immune Dynamics in Cancer
Promotie
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Using insertional mutagenesis to identify breast cancer drivers and therapy resistance genes in mice
In this thesis, we used genetically engineered mouse models to identify genes and pathways that are involved in ILC formation and in the development of resistance to FGFR-targeted therapy.
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Upconverting nanovesicles for the activation of ruthenium anti-cancer prodrugs with red light
Promotor: E. Bouwman, Co-promotor: S. Bonnet
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The good? The bad? The mutant! Characterization of cancer-related somatic mutations and identification of a selectivity hotspot in adenosine
G protein-coupled receptors (GPCRs), one of the largest families of membrane proteins, are responsive to a diverse set of physiological endogenous ligands including hormones and neurotransmitters.
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PLGA-based particulate vaccine delivery systems for immunotherapy of cancer
Promotores: W. Jiskoot, F. Ossendorp
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Nieuwe ‚Brexit’ publicatie van Christa Tobler
In het Maastricht Journal of European and Comparative Law is zojuist een artikel van Christa Tobler met de titel ‚One of Many Challenges After ‚Brexit’. The Institutional Framework of an Alternative Agreement – Lessons from Switzerland and Elsewhere?’ verschenen (Maastricht Journal of European and Comparative…
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Modelling metastatic melanoma in zebrafish
Death in all types of melanomas is generally caused by metastasis. Uveal melanoma (UM) is the most common intraocular melanoma, there are currently no (patient-derived) animal models that faithfully recapitulate metastatic dissemination of UM.
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Role of integrin adhesions in cellular mechanotransduction
Promotor: B. vd Water, T. Schmidt, Co-Promotor: E.H.J. Danen
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Christa Tobler spreekt over Brexit en geschillenbeslechting
Op 8 november 2017 organiseerde The Law Societies Joint Brussels Office van het Verenigd Koninkrijk in het Europese Parlement te Brussel een seminar over het onderwerp ‘Brexit: Where & How to Enforce: Building Blocks for a New Dispute Settlement System’.
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actomyosin contraction as a driving force of invasive lobular breast cancer
In this thesis, we used genetically engineered mouse models and a variety of cell-culture based assays to identify genes and pathways that are involved in the development and treatment of invasive lobular carcinoma (ILC).
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Phenotypic screening with 3D cell-based assays
Traditional drug discovery approaches have been hampered by (in vitro) cell-culture models that poorly represent the situation in the human body.
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Using Liposomes; Opportunities for Treatment of Atherosclerosis and Cancer
This thesis focuses on using liposomes in two different treatment strategies; vaccination (or immunotherapy) and delivery of a small molecule, and in two different disease models; cancer and atherosclerosis.
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congresboek New dynamics in the European Integration Process – Europe post Brexit
De negende Network Europe Conference in Edinburgh werd in juni 2017 gehouden en was georganiseerd door het Europa Instituut in Zurich.
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Hoe de Brexit beleidsmakers en onderzoekers naderbij brengt
Rector magnificus Carel Stolker neemt op 8 februari afscheid. Als er één thema als een rode draad door zijn carrière loopt, dan is het de verbinding tussen universiteit en maatschappij. In deze serie afscheidsgesprekken gaat Stolker nog eenmaal in gesprek met mensen van binnen en buiten de universiteit.…
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Armin Cuyvers in Brexit panel Nederlandse Vereniging Europees Recht
Op 11 november was Armin Cuvyers, Universitair docent aan het Europa Instituut in Leiden, een van de sprekers over Brexit bij de najaarsvergadering van de NVER (Nederlandse Vereniging van Europees Recht).
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Armin Cuyvers en Daniel Carter spreken over brexit in Edinburgh
Op 1 en 2 november 2018 presenteerden Armin Cuyvers en Daniel Carter twee papers tijdens de LERU-conferentie over Implications of Brexit: EU and Post-EU Constitutional and Substantive Law.
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Joost Augusteijn over Brexit en de Ierse grens
De Brexit is in zicht: eind maart volgend jaar stapt het Verenigd Koninkrijk uit de Europese Unie. Er ligt een voorlopig akkoord op tafel, maar hoe zit het met de Ierse grens? Joost Augusteijn, universitair hoofddocent, spreekt over de Brexit, de mogelijk nieuwe grens en de gevolgen.
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Armin Cuyvers geeft lezing over Brexit voor Clingendael
Op 5 december gaf Armin Cuyvers een lezing over de juridische complicaties rondom Brexit voor Clingendael.
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Armin Cuyvers geeft lezing over Brexit voor Mordenate College
Op 7 december gaf Armin Cuyvers (Universitair docent aan het Europa Instituut) een lezing over de juridische complicaties rondom Brexit voor Mordenate College.
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Noord-Ierland maakt Brexit moeilijk: Armin Cuyvers in Leidsch Dagblad over Brexit
Voor de wekelijkse wetenschapspagina van het Leidsch Dagblad werd Armin Cuyvers geïnterviewd over Brexit en de juridische complicaties rondom Noord-Ierland.
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Brexit-procedure in kaart
Het Verenigde Koninkrijk heeft gekozen voor een Brexit. Wat zijn de juridische spelregels bij een uittreding uit de EU? Hoogleraar Christa Tobler bracht het in kaart.