581 zoekresultaten voor “clinical traits” in de Publieke website
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General plant strategies and functions in wetlands: Global trait-based analyses
Wetland plants are distinguished from plants of other terrestrial ecosystems by their adaptations to specific habitat stresses, including waterlogged and flooding and the subsequent abundance of phytotoxic compounds.
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Phenotypic plasticity and genetic adaptation of plant functional traits on global scales
In light of climate change, it is crucial to determine whether plant species can adapt to future climates to avoid extinction. Plants adapt to various conditions by altering their functional traits, such as leaf size or photosynthetic rate. Some traits appear linked and vary together between species,…
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Remote (sensing) functional biodiversity: exploring drivers of trait variation and spectral variability in the Arctic
Globally and regionally, biodiversity is declining and there are shifts in species’ occurrences and functional traits.
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Disentangling drought-responsive traits with focus on Arabidopsis
In recent decades, climate change has led to more frequent and severe drought events, causing serious consequences such as increased forest mortality and significant crop yield losses. Understanding how drought affects plants, especially economically important herbaceous species, is crucial for predicting…
- Clinical Neuropsychology (MSc)
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Multi-sensor Earth Observation Products through phenology and trait-based priors
What are the behaviours of plant traits throughout various points in the growing season in a radiative transfer model framework and how well can this knowledge be integrated through data assimilation to provide priors for robust local and global vegetation products and analysis?
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A meta-analysis of wetland plant traits in relation to the strategies of wetland plants and the impacts on ecosystem functioning
What are trait-trait relationships in wetlands? To what extent the so-called leaf economics traits deviate from terrestrial ecosystems? How traits specific to wetland plant relate to plant strategies? What’s the relationship between wetland plant traits to the ecosystem functioning (e.g. productivity,…
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Phenotypic engineering of photosynthesis related traits in Arabidopsis thaliana using genome interrogation
Promotor: P.J.J. Hooykaas, Co-Promotor: E.J. van der Zaal
- Clinical and Health Psychology (research) (MSc)
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Optimisation of first clinical studies in special populations: towards semi-physiological pharmacokinetic models
M. Danhof, Co-promotores: J. Freijer, A. Yassen
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Online Course Clinical Research Regulation in the Netherlands
Are you planning to conduct clinical research in the Netherlands? In this online course, you are introduced to legislation and procedures on clinical research in the Netherlands. It will help you prepare and submit your research file efficiently. The first three themes ‘The Dutch Review System’ , ‘The…
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Dosing considerations for preterm neonates: from pharmacometrics to clinical practice
Prematurely born neonates require, amongst others, pharmaceutical therapy. Dosing guidelines for these therapies are often based on data from term born neonates or older infants, while these are not necessarily similar to prematurely born neonates.
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Online Course Clinical Kidney, Pancreas and Islet Transplantation
Kidney transplantation is a major advance of modern medicine. This course will give you state of the art updates about what used to be an experimental, risky, and very limited treatment option more than 50 years ago and is now routinely performed in many countries worldwide.
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Chemical biology of sphingolipids: fundamental studies and clinical applications
Overkleeft Aerts
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formulation for skin barrier repair : from ex vivo assessment towards clinical studies
The stratum corneum is the outermost skin layer and consists of dead cells embedded in a lipid matrix.
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Exploring big data approaches in the context of early stage clinical
Als gevolg van de grote technologische vooruitgang in de gezondheidszorg worden in toenemende mate gegevens verzameld tijdens de uitvoering van klinische onderzoeken.
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Mapping for meaning: using concept maps to integrate clinical and basic sciences in medical education
Het onderwerp van dit proefschrift is integratie van klinische kennis en kennis van de basisvakken in het medisch onderwijs en de rol die concept maps kunnen spelen in het expliciet maken van deze zogenoemde verticale integratie.
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Jianhong Zhou
Wiskunde en Natuurwetenschappen
j.zhou@cml.leidenuniv.nl | 071 5271494
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Global fitness maximising approaches to evaluate the trade-offs involved in the evergreen and deciduous conundrum
Which traits and/or trade-offs determine benefits of being deciduous or evergreen?
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Monitoring drought and salinity stress in agriculture by remote sensing for a sustainable future
Food security is challenged by a growing global population and by climate change. Drought and soil salinity are considered the most important ones that inhibit crop yield and distribution. Worryingly, climate change is predicted to increase not only their frequency and severity, but also their co-occurrence,…
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Patient-centered statistics in clinical prediction, trials and meta-analysis
Promotie
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Remote sensing-based assessment of functional diversity for polar ecosystems
1: What is the relative importance of alfa and beta biodiversity in polar ecosystems, and how does intraspecific variation influence this? 2: How can we use remote sensing to determine functional biodiversity (within communities) in polar ecosystems? 3: Temporal and spatial scales of functional biodiversity:…
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Effects of pesticides on aquatic macrofauna in the field
Promotores: W.J.G.M. Peijnenburg, G.R. de Snoo, Co-promotor: M.G. Vijver
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Non-invasive biomarkers for inflammatory skin diseases: towards systems dermatology
Inflammatory skin diseases such as psoriasis and atopic dermatitis can severely impact both the physical and social aspect of a patient’s life. Aberrant inflammatory responses are thought to be a major causative factor in these disorders, but an abundance of different factors contribute to the development…
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Quantitative modelling of the response of earthworms to metals
Promotor: Prof.dr. W.J.G.M. Peijnenburg
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Do fungi differ? Understanding the mechanisms of mycorrhizal fungal impacts on soil C sequestration
How presence, abundance and enzymatic activities of AM and EM fungi differently affect soil carbon sequestration processes?
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Using soil inoculations for ecological restorations
How soil microbial composition impacts structure and composition of the aboveground plant and animal communities?
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The application and clinical utility of visual coronary artery calcium evaluation on routine chest computed tomography for cardias risk stratification
Promotie
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Pharmacogenomics in drug development: implementation and application of PKPD model based approaches
Promotor: Prof.dr. M. Danhof, Co-Promotor: J. de Jongh
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Assemblage and functioning of bacterial communities in soil and rhizosphere
Promotores: J.A.van Veen, P.L.G.Klinkhamer. Co-promotor: E.E.Kuramae
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The quantification of growth hormone secretion : application of model-informed drug development in acromegaly
Growth hormone profiles are pulsatile and highly variable between individuals, limiting the implementation of mathemathical models to quantify an individual's secretion.
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Wetenschappelijke publicaties
Een lijst met wetenschappelijke publicaties samengesteld door het team van het TRIXY Expertisecentrum.
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Solvent tolerance mechanisms in Pseudomonas putida
Bacterial biocatalysis constitutes a sustainable alternative for high-value chemicals production by enabling the utilization of renewable feedstocks.
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Temperature effects on genetic and physiological regulation of adaptive plasticity
Promotor: P.M. Brakefield
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Medicijnkandidaat uit Leiden klaar voor laatste klinische onderzoeksfase
Voor veel scheikundigen aan de universiteit is het de ultieme droom: een middel ontwikkelen dat écht bij patiënten terechtkomt. Maar de weg daarnaartoe is lang en onzeker. Nu mag het Leidse middel nizubaglustat door naar de derde fase van klinisch onderzoek. Dat is mogelijk dankzij een investering van…
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The evolution and plasticity of life histories upon variation in nutrition: on aging focused integrative approach
Promotores: Prof.dr. P.M. Brakefield, Prof.dr. B.J. Zwaan (Wageningen Universiteit)
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Functional xylem anatomy: intra and interspecific variation in stems of herbaceous and woody species
My PhD thesis investigates the ecological significance of resistance against drought-induced air bubble formation inside the water conduits of plants (embolism), and the plasticity and functional aspects of stem anatomical traits in woody and herbaceous species.
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Riccardo Mancinelli
Wiskunde en Natuurwetenschappen
r.mancinelli@cml.leidenuniv.nl | +31 71 527 2727
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Anthropogenic effects on links between macro-invertebrate diversity and ecosystem functioning
How are links between macro-invertebrate diversity and ecosystem functioning influenced by anthropogenic pressures?
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Quantitative systems pharmacology modeling of biotherapeutics in oncology
In this thesis, mathematical modeling and simulation was applied as a tool to inform quantitative decision making in oncology drug discovery and development.
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Evolution and development of flowers, fruits and inflorescences of Phalaenopsis and other orchid species
The study of orchid flowers, fruits, and inflorescences is crucial due to the remarkable diversity of orchid species and their unique adaptations to pollinators and seed dispersers. However, our understanding of the evolution and development of these organs within the orchid family remains limited.
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Modulation of plant chemistry by rhizosphere bacteria
Plant-microbe interaction resulted in different physio/chemical responses by host plant and interacting rhizobacteria.
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Empirical signatures of universality, hierarchy and clustering in culture
In this thesis,
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Cool little kids
De effectiviteit van een vroeg interventieprogramma voor angstige peuters in Nederland
- Alumini
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Meeloopdag - Clinical Psychology
Studievoorlichting
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Meeloopdag - Clinical Psychology
Studievoorlichting
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Meeloopdag - Clinical Neuropsychology (MSc Psychology)
Studievoorlichting
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Pharmacogenomics in Drug Development: Implementation and Application of PKPD Model Based Approaches
Model based approaches, integrating physiological parameters or linking exposure with response, are powerful tools to quantify and evaluate the impact of genetic differences that are reflected as variability of drug exposure and/or clinical response(s). This thesis “Pharmacogenomics in Drug Development: …
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Onderwijs
Het onderwijsprogramma van Clinical Psychology is gericht op het verkrijgen van gespecialiseerde kennis van psychopathologie, diagnostische- en behandelvaardigheden en daaraan gerelateerd wetenschappelijk onderzoek.