622 zoekresultaten voor “bioactive molecules” in de Publieke website
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Next generation bacitracin: reimagining a classic antibiotic
Given the accelerating appearance of antimicrobial resistance, there is an urgent need for more fundamental research into novel antibiotic strategies. The work in this thesis helps to address this global problem by developing new antibiotic compounds, inspired by the antibacterial mechanisms of the…
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Lipid signaling and inflammation: metabolomics for better diagnosis and treatment strategy
Lipid signaling is an essential biological event/process in a plethora of pathophysiological conditions. The underlying idea of this thesis is that many of the roles and the complex interplay of the individual signaling lipids in inflammatory processes and related conditions in health and disease is…
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Water related adsorbates on stepped platinum surfaces
Promotor: M.T.M. Koper, Co-Promotor: L.B.F. Juurlink
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Natural Products Lab
Wij richten ons op natuurlijke producten van onderzoek, de traditionele geneeskunde, etnobotanie en fytochemie.
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Hydrocarbons in interstellar ice analogues: UV-vis spectroscopy and VUV photochemistry
Promotor: Prof.dr. H.L.V. Linnartz
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How Electrostatic Interactions Drive Nucleosome Binding of RNF168 & PSIP1
The studies presented in the work show the potential of the integrative use of biophysical data in defining the structural basis of protein interactions.
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Modulation of leukocyte homeostasis in atherosclerosis
Promotores: Prof.dr. E.A.L. Biessen, Prof.dr. T.J.C. van Berkel
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Computational electrocatalysis
This dissertation focused on computational methods based on first principles calculations using the Density Functional Theory (DFT) framework. Emphasis was laid on affordable methods that can provide a tradeoff between computational expense and accuracy.
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Design and application of dextran based cross-linked networks
This thesis describes the design, characterization and application of dextran based crosslinked network.
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Glucocerebrosidase and glycolipids: In and beyond the lysosome
The lysosomal β-glucosidase named glucocerebrosidase (GCase) is a retaining β-glucosidase that hydrolyzes the glycosphingolipid glucosylceramide (GlcCer) to ceramide and glucose at acid pH.
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Chemical Synthesis of Fragments of Streptococcal Cell Wall Polysaccharides
This thesis describes the design and synthesis of fragments of various cell wall carbohydrates of the Streptococcus species, including the branched Group B-specific antigen (GBC) of Group B Streptococcus, glycerol phosphate (GroP) modified group A carbohydrate (GAC), and the O-acetylated type 1 capsular…
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Chemical functionalization of the graphene surface for electrical and electrochemical sensing application
Advanced sensing techniques require graphene with high quality and well-controlled surface chemistry.
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Molecular and Nano-Engineering with Iron, Ruthenium and Carbon: Hybrid structures for Sensing
Metal complexes and 2D materials like graphene were combined to produce structures that can function as sensors.
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Role of integrin adhesions in cellular mechanotransduction
Promotor: B. vd Water, T. Schmidt, Co-Promotor: E.H.J. Danen
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The Role of Linker DNA in Chromatin Fibers
The genetic information of all living organisms is contained in their DNA. Cells modify the degree of DNA compaction by epigenetics, which largely determines what genes are read out and which genes are transcriptionally silent.
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Chemical genetic approaches for target validation
Drug development is a time- and resource-consuming process that starts with the discovery and validation of a (protein) target that contributes to pathogenesis or disease progression.
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Nuclear Quantum Effects in Solid Water
Ice, the solid state of water, plays an important role on our planet as well as the entire universe.Despite the fact that an individual water molecule has a very simple structure, its chemical bonding in the solid phase can be surprisingly complex.
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On the geometry of fracture and frustration
Promotor: Prof.dr. M.L. van Hecke, Co-Promotor: V. Vitelli
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Antibiotic Discovery: From mechanistic studies to target ID
The investigations described in this thesis lay out strategies aimed at advancing antibiotic research and development. The examples presented revolve around two main approaches: understanding drug-target interactions and target identification.
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Reverse engineering of drug induced QT(c) interval prolongation: Towards a systems pharmacology approach
Promotor: M. Danhof Co-promotor: O.E. Della Pasqua
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Supramolecular peptide amphiphile nanoparticles as a novel allergy vaccine platform
Bet v1, the major allergen in birch pollen, is one of the main causes of allergies such as asthma and rhino-conjunctivitis. It is the main cause of birch pollen allergy in humans.
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Synthetic Study on ADP-ribosylation
This Thesis focuses on the design and synthesis of ADP-ribosylated compounds that can be applied in biological studies.
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The puzzle of protoplanetary disk masses
My work focuses on a class of astronomical objects called protoplanetary disks.
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Towards automated identification of metabolites using mass spectral trees
Promotor: Prof.dr. T. Hankemeier, Co-promotor: Theo Reijmers
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The ins and outs of ligand binding to CCR2
Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: L.H. Heitman
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Systems diagnosis in chronic disease: prediction and evaluation
Promotor: J. van der Greef, T. Hankemeier; Co-promotor: H.A. van Wietmarschen
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Neutral outflows in high-redshift dusty galaxies
Outflows are crucially important for the gas budget and evolution of luminous star-forming galaxies and AGNs, with observed mass outflow rates of the same order as the star formation rate. Greater star formation and black hole growth lead to more intense feedback and outflows, resulting in self-regulated…
- Biomedische wetenschappen
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Applications of graphene in nanotechnology : 1D diffusion, current drag and nanoelectrodes
Graphene nanoribbons (GNRs) are used as a current carrying substrate in investigation of current-induced forces in a low-temperature STM (chapter 2).
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Probing molecular layers with low-energy electrons
Molecular materials have been a subject of interest in fundamental research and applications for decades, and have been studied as bulk crystals, (thin) films and as individual molecules, due to the large variety in their properties. This dissertation explores pentacene crystals near the two-dimensional…
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Genomics applications of nanopore long-read sequencing for small to large sized genomes
In this thesis I highlight the applications of Oxford Nanopore Technologies (ONT) sequencing. This technique is a relatively new approach in the sequencing field, where nanopores are embedded in a membrane, DNA molecules are pulled through nanopores and an electrical current serving as the sequencing…
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Anti-microbial and Anti-biofilm compounds From Indonesian Medicinal Plants
Promotor: C.A.M.J.J. van den Hondel, Co-promotor: Sandra de Weert
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Using insertional mutagenesis to identify breast cancer drivers and therapy resistance genes in mice
In this thesis, we used genetically engineered mouse models to identify genes and pathways that are involved in ILC formation and in the development of resistance to FGFR-targeted therapy.
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Exploring the chemical space of post-translationally modified peptides in Streptomyces with machine learning
The ongoing increase in antimicrobial resistance combined with the low discovery of novel antibiotics is a serious threat to our health care.
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Mononuclear spin-transition materials based on the bapbpy scaffold
Promotor: Prof.dr. E. Bouwman, Co-Promotor: S. Bonnet
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Inhibitor Selectivity: Profiling and Prediction
Less than 1 in 10 drug candidates that enter phase 1 clinical trials actually gets approved for human use.
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Arbeidsmarkt
Een volledige academische studie bestaat uit een bachelor én een master. De Universiteit Leiden stimuleert studenten om na hun bachelor door te gaan met de master.
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High-throughput simulation studies of angiogenesis - Reverse engineering the role of tip cells and pericytes in vascular development
Promotor: Prof.dr. R.M.H. Merks
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A computational study of structural and excitonic properties of chlorosomes
The long-held desire - to link structure directly to function and to explain molecular mechanisms based on basic chemical or physical principles - is finally coming closer, satisfying not only our scientific curiosity but also offering new solutions to the many challenges in the field of health, energy…
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De Quantumcomputer
De wereldwijde race naar de quantumcomputer is in volle gang. Deze computer kan rekenklussen aan waarvan we nu alleen maar dromen, zoals het razendsnel vinden van eiwitten die als medicijn kunnen dienen. Leidse natuurkundigen ontdekten hoe je het Majorana-deeltje als bouwsteen voor deze quantumcomputer…
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Zoeken naar een minuscule fata morgana
Een fata morgana ontstaat wanneer door zonlicht de lucht boven de grond opwarmt. Natuurkundige Michel Orrit en zijn collega’s hebben dit principe gebruikt op de schaal van nanometers om enkele moleculen te zien. Hun artikel verscheen op 15 oktober in Science.
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Nieuwe meetmethode brengt moleculaire chips dichterbij
Leidse en Delftse wetenschappers hebben vastgesteld wat elektronentransport via een enkel molecuul zo moeilijk maakt. Ze ontdekten dit dankzij een nieuwe meetmethode. Hun bevinding brengt elektronische chips een stap dichterbij. Ze publiceerden erover in Nature Nanotechnology.
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Kwantummechanisch schakelen bij kamertemperatuur
Elektrongolven kunnen elkaar versterken maar ook tegenwerken. Dit heet destructieve interferentie. Uit metingen aan kleine structuren bij lage temperaturen was al bekend dat dit kan leiden tot een lagere geleiding. Een team van wetenschappers van o.a. de Universiteit Leiden en de Rijksuniversiteit Groningen…
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Data Science voor state-of-the-art bloedbankieren (BloodStart)
Er zijn in Nederland ongeveer 300.000 mensen die regelmatig bloed geven. Vrouwen kunnen tot drie keer per jaar bloed geven en mannen tot vijf keer, wat neerkomt op ongeveer een miljoen bloeddonaties per jaar. Patiënten die dit donorbloed krijgen, verkeren al in een kwetsbare positie. Daarom is kwaliteitsbewaking…
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Archief
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Faculteit Wiskunde en Natuurwetenschappen
Het onderzoek binnen de Faculteit der Wiskunde en Natuurwetenschappen richt zich op de volle breedte van de bètawetenschappen en varieert van wiskunde, informatica, sterrenkunde, natuurkunde, scheikunde en bio-farmaceutische wetenschappen tot aan biologie en milieuwetenschappen. De gastlessen die deze…
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Over de opleiding
Bij MST worden chemie en technologie gecombineerd. De opleiding biedt je de gelegenheid om kennis te maken met de diverse richtingen in de chemie en de (chemische) procestechnologie.
- Wetenschapsdossiers
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Leidse chemicus Bonnet over Nobelprijs scheikunde
Samen met onderzoekers Jean-Pierre Sauvage en Sir J. Fraser Stoddart heeft de Groningse hoogleraar Ben Feringa de Nobelprijs voor de Scheikunde gewonnen. ‘Te gek’, reageert de Leidse chemicus Sylvestre Bonnet, die bij Sauvage promoveerde.
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Leids Instituut voor Onderzoek in de Natuurkunde
Onderzoek aan het Leids Instituut voor Onderzoek in de Natuurkunde (LION) is fundamenteel en nieuwsgierigheids-gedreven. Al onze wetenschappers delen de wens om de kennis van de wereld om ons heen te vermeerderen, in een open, nieuwsgierige sfeer, waarin innovatieve ideeën ontstaan die toepassingen…