1,060 zoekresultaten voor “high throughput screening and microscopy” in de Publieke website
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Hai Lin
Wiskunde en Natuurwetenschappen
h.x.lin@cml.leidenuniv.nl | +31 71 527 7460
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Science Friction (SciFri)
Hoe kan wrijving op de nanoschaal gereduceerd worden?
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High fidelity DNA replication and repair
Promotie
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Gastrointestinal malignancies in high-risk populations
Promotie
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Using mouse models to uncover genes driving tumorigenesis and therapy resistance in human breast cancer
To improve cancer treatments, personalized medicine approaches have aimed to identify exactly which mutations are driving tumor development in a given patient and specifically target these mutations using precision therapies.
- Maartje Draak Seminars
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Dynamics and regulation of the oxidative stress response upon chemical exposure
The focus of the described research in this thesis is on the oxidative stress response (Nrf2 pathway). The aim of the research presented in this thesis is to obtain more information concerning microRNAs which are involved in the Nrf2 pathway, to determine and evaluate the application of microRNAs for…
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Towards a mechanistic understanding of nanoparticle behavior using zebrafish
The work described in this dissertation contributes to a better mechanistic understanding of nanoparticles in vivo. To achieve that goal, we used the zebrafish as a highly predictive pre-screening model of nanoparticles.
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A Model Membrane Approach to Elucidate the Molecular Organization in the Skin Barrier
Promotor: J. A. Bouwstra
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Using cryo-EM methods to uncover structure and function of bacteriophages
Bacteriophages, or phages for short, are the most abundant biological entity in nature. They shape bacterial communities and are a major driving force in bacterial evolution.
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Understanding the uptake and internal distribution of metallic nanoparticles in Danio rerio larvae
The aim is to discover where differently shaped metal nanoparticles distributes in Danio rerio, linking the distribution with genomic responses and so come up with a Mode of Action.
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Photothermal studies of single molecules and gold nanoparticles: vapor nanobubbles and conjugated polymers
Promotor: M.A.G.J. Orrit
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Photon detection at subwavelength scales
Promotor: Prof.dr. E. Eliel, Co-Promotor: M.J.A. de Dood
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d interplay between local three- dimensional chromatin architecture and gene expression
Nucleoid associated proteins maintain the architecture of the bacterial chromosome and regulate gene expression, hinting that their role as transcription factors may involve local three-dimensional chromosome re-modelling.
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Applications for activity-based probes in biomedical research on glycosidases
Lysosomal glycosidases are acid hydrolases that fragment glycoconjugates in lysosomes.
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Network flow algorithms for discrete tomography
Promotor: R. Tijdeman, Co-promotor: H.J.J. te Riele
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Giant unilamellar vesicles: An efficient membrane biophysical tool and its application in drug delivery studies
Promotor: A. Kros
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The electrode-electrolyte interface in CO2 reduction and H2 evolution: a multiscale approach
Electrocatalysis allows for storing electricity or converting it into chemical bonds, producing chemical building blocks and fuels using renewable resources.
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Wiskunde en Natuurwetenschappen
De Faculteit Wiskunde en Natuurwetenschappen
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Paul Wouters
Faculteit der Sociale Wetenschappen
p.f.wouters@fsw.leidenuniv.nl | +31 71 527 2727
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Jian Wang
Faculteit der Sociale Wetenschappen
j.wang@cwts.leidenuniv.nl | +31 71 527 2727
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Vincent Chang
Faculteit der Geesteswetenschappen
v.k.chang@hum.leidenuniv.nl | +31 71 527 2151
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Frank Baas
Faculteit Geneeskunde
f.baas@lumc.nl |
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Wij bieden
Als wetenschappelijke partner biedt het Sport Data Center (sport)organisaties een aantal diensten.
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On the coexistence of Landau levels and superconductivity
In unconventional high temperature superconductors, supercurrent vortices are known to spoil the Landau levels. In this thesis the emergence of Landau levels is studied in different types of superconductors: Weyl superconductors, and the Fu-Kane heterostructure.
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Personalised medicine for multiple outcomes: methods and application
The main objective of this thesis was to develop clinically relevant survival models for patients with high-grade soft tissue sarcoma of the extremities, in particular the development and validation of prediction models for use in clinical practice.
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Enlightening the Primordial Dark Ages
This thesis is dedicated to the exploration of the primordial dark ages: unknown physics during the earliest stages of the Universe’s expansion that have not yet been directly probed by observations. Cosmic inflation is a burst of exponential expansion of space after the “Big Bang”.
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Oscar Rueda
Wiskunde en Natuurwetenschappen
o.rueda@cml.leidenuniv.nl | +31 71 527 2727
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Ewout Steyerberg
Faculteit Geneeskunde
e.w.steyerberg@lumc.nl | +31 71 526 9700
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Preclinical validation of putative targets in cardiovascular and metabolic disease
Cardiovascular disease is the number one cause of death worldwide. The most important risk factor for developing this disease is high cholesterol levels in the blood.
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The Infrared Spectrum of Massive Protostars
We have conducted a full spectral line survey of the 3-13 micron region of two massive protostars, AFGL 2591 and AFGL 2136, for the first time at high spectral resolution.
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Cyclophellitol analogues for profiling of exo- and endo-glycosidases
To this day, all cyclophellitol-based inhibitors and ABPs have been close analogues of their natural substrate counterparts. As a result, these probes showed high selectivity towards their target glycosidases.
- Quantum and Society
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Europese ‘stoffenbibliotheek’ voor ontwikkeling van nieuwe medicijnen
Universiteit Leiden is partner in een nieuw Europees platform van bedrijven en onderzoeksinstellingen dat de basis gaat leggen voor nieuwe geneesmiddelen. Een enorme gemeenschappelijke ‘bibliotheek’ van bestaande en nog te ontwikkelen chemische verbindingen met maximaal 500.000 moleculen zal ongekende…
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Europese ‘stoffenbibliotheek’ voor ontwikkeling van nieuwe medicijnen
Universiteit Leiden is partner in een nieuw Europees platform van bedrijven en onderzoeksinstellingen dat de basis gaat leggen voor nieuwe geneesmiddelen. Een enorme gemeenschappelijke ‘bibliotheek’ van bestaande en nog te ontwikkelen chemische verbindingen met maximaal 500.000 moleculen zal ongekende…
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Nobelprijs Scheikunde voor 3D-beelden van moleculen
De Nobelprijs voor Scheikunde 2017 is uitgereikt aan Jacques Dubochet, Richard Henderson en Joachim Frank, voor hun ontwikkeling van de cryo-elektronenmicroscopie. Met deze techniek kunnen biomoleculen in 3D in beeld gebracht worden, legt hoogleraar Ultrastructuurbiologie Ariane Briegel uit.
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Cold gas in distant galaxies
The formation and evolution of galaxies is fundamentally driven by the formation of new stars out of cold gas.
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Leiden Genome Technology Center
De faciltieit ontwikkelt en gebruikt, high-throughputmethoden toe voor genomisch onderzoek.
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Thromboinflammation in high-risk human populations
Promotie
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Quantum dots in microcavities: From single spins to engineered quantum states of light
A single self-assembled semiconductor quantum dot in a high-finesse optical microcavity - the subject of this thesis - is an interesting quantum-mechanical system for future quantum applications. For instance, this system allows trapping of an extra electron and thus can serve as a spin quantum memory,…
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Life Cycle Assessment of Nanomaterials and Risk Assessment.
What is the environmental impact, the human health impact and the life cycle and production costs of the lab, pilot and commercial diffusion of nanowires and nanowire-based photovoltaic technologies?
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Nieuwe antibiotica
Ziekteverwekkende bacteriën zijn steeds vaker resistent voor de huidige antibiotica. De vraag naar nieuwe antibiotica wordt daarmee steeds groter. Professor Gilles van Wezel zoekt naar nieuwe vormen van antibiotica in goede bacteriën die in de grond leven.
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Multi-Objective Bayesian Global Optimization for Continuous Problems and Applications
A common method to solve expensive function evaluation problem is using Bayesian Global Optimization, instead of Evolutionary Algorithms.
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Small scale kinematics of massive star-forming cores
Promotor: Prof.dr. E.F. van Dishoeck, Co-Promotor: M.R. Hogerheijde
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X-ray spectroscopy of merging galaxy clusters
This thesis focuses on the X-ray spectral analysis of merging galaxy clusters and the plasma code development for future high-resolution X-ray spectroscopy observations.
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Statistical methods for microarray data
Promotores: J.C. van Houwelingen, S.A. van de Geer
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Infrared spectroscopy of astrophysically relevant hydrocarbons
This thesis is about the study of hydrocarbons via infrared spectroscopy.
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Towards in-cell structural study of light-harvesting complexes : an investigation with MAS-NMR
Light-Harvesting Complex II (LHCII) is responsible for light absorption and excitation energy transfer in plants and photosynthetic algae, while in high light it undergoes conformational changes by which it quenches excitations to prevent photodamage.
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Design and application of dextran based cross-linked networks
This thesis describes the design, characterization and application of dextran based crosslinked network.
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Atmospheres of hot alien Worlds
Promotor: Prof.dr. I.A.G. Snellen, C.U. Keller