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1,179 zoekresultaten voor “bart cancer metastasis” in de Publieke website

• Cell-autonomous and host-dependent CXCR4 signaling in cancer metastasis: insights from a zebrafish xenograft model Onderzoeksoutput

  Promotor: A.H. Meijer, Co-promotor: B.E. Snaar-Jagalska

• Mechanisms of Ewing sarcoma metastasis Onderzoeksoutput

  Promotor: T. Schmidt, Co-Promotor: B.E. Snaar-Jagalska

• Image-based phenotypic screening for breast cancer metastasis drug target discovery Onderzoeksoutput

  The main aim of this thesis was to unravel the signaling and regulatory networks that drive tumor cell migration during breast cancer metastasis.

• multifaceted roles of Grainyhead-like transcription factor-2 in breast cancer Onderzoeksoutput

  Breast cancer is the most common cancer in women worldwide. Metastasis, the process by which cancer cells spread to other parts of the body, makes treatments less effective. It is important to unravel the mechanism of metastasis.

• Identification of novel targets in prostate cancer progression Onderzoeksoutput

  Promotor: B. van de Water, Co-promotor: E.H.J. Danen

• xenograft model: identification of novel mechanisms driving prostate cancer metastasis Onderzoeksoutput

  Prostate cancer (PCa) is one of the most prevalent cancer in males.

• Novel regulators of prostate cancer stem cells and tumor aggressiveness Onderzoeksoutput

  Promotor: R.C.M. Pelger Co-Promotor: G. van der Pluijm

• RNA splicing in breast cancer progression Onderzoeksoutput

  In this thesis, we aimed to better understand the underlying mechanisms involved in TNBC progression and metastasis formation and discover new targets to reduce breast cancer related deaths.

• Pulling the strings on anti-cancer immunity Onderzoeksoutput

  Promotores: J. Jonkers, K.E. de Visser

• Exploring Grainyhead-like 2 target genes in breast cancer Onderzoeksoutput

  The objective of this study was to investigate the expression and function of GRHL2 in different breast cancer subtypes.

• PI3K signaling and adherens junctions in invasive lobular breast cancer Onderzoeksoutput

  Invasive lobular carcinoma (ILC) is the second most common type of breast cancer.

• Discovery of BUB1 kinase inhibitors for the treatment of cancer Onderzoeksoutput

  The spindle-assembly checkpoint (SAC) is a safety mechanism which secures accurate chromosome segregation during mitosis.

• BRCA1-associated breast cancer: finding new weapons for an old villain Onderzoeksoutput

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• Development of novel anti-cancer strategies utilizing the zebrafish xenograft model Onderzoeksoutput

  In this thesis, we will utilize embryonic zebrafish tumour models to understand the interaction between engrafted human cancer cells and macrophages from the host, test drug administration modalities and anti-cancer efficacies of newly-developed PDT and PACT compounds, and test a light-triggered liposomal…

• Cancer chess: molecular insights into PARP inhibitor resistance Onderzoeksoutput

  The clinical potential of applying synthetic lethality to cancer treatment is famously demonstrated by the BRCA1/PARP1 paradigm: a tumor specific defect in BRCA1 – a component of the DNA double-strand break (DSB) repair pathway homologous recombination (HR) – results in a remarkable sensitivity to PARP1…

• Patient-derived models of breast cancer: a breakthrough story of the duct Onderzoeksoutput

  To improve treatment of breast cancer patients it is important to understand all stages of breast cancer from initiation to in situ disease and progression to invasive disease. In this thesis we use intraductal injections of patient derived tissue to model ductal carcinoma in situ and invasive breast…

• Precision modeling of breast cancer in the CRISPR era Onderzoeksoutput

  The molecular mechanisms that instigate a healthy cell to become malignant are fueled by (epi)genetic alterations in so-called driver genes.

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  Bart Bulsing Technisch Informatiebeheerder / Tekenaar

  Expertisecentrum Vastgoed

  b.m.bulsing@vastgoed.leidenuniv.nl | +31 71 527 1203

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  Bart Lenselink Gast Onderzoeker

  Wiskunde en Natuurwetenschappen

  e.b.lenselink@lacdr.leidenuniv.nl | +31 71 527 2727

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  Bart Hoenen Advisor Entrepreneurship (gast)

  Bestuursbureau

  b.m.j.hoenen@bb.leidenuniv.nl | +31 71 527 2531

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  Bart Schreuders Onderzoeker/docent

  Faculteit Rechtsgeleerdheid

  h.g.schreuders@law.leidenuniv.nl | +31 71 527 2727

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  Bart Collard Buitenpromovendus

  Faculteit Rechtsgeleerdheid

  b.j.collard.2@umail.leidenuniv.nl | 071 5275200

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  Bart Mertens

  Faculteit Geneeskunde

  b.mertens@lumc.nl | +31 71 527 6817

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  Bart Appelhof Onderzoeker / gast

  Wiskunde en Natuurwetenschappen

  b.appelhof@biology.leidenuniv.nl | +31 71 527 2727

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  Bart Gorissen Docent

  Faculteit Rechtsgeleerdheid

  b.j.e.gorissen@law.leidenuniv.nl | 071 5272727

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  Bart Vogelaar Universitair docent

  Faculteit der Sociale Wetenschappen

  b.vogelaar@fsw.leidenuniv.nl | +31 71 527 6022

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  Bart Wentholt Meewerkend coördinator MDA open access

  Universitaire Bibliotheken Leiden

  b.l.r.wentholt@library.leidenuniv.nl | +31 71 527 2727

• Orientational Order and Confinement in Biological Tissues Onderzoeksoutput

  This thesis investigates how cell shape and collective behavior influence the dynamics and structure of biological tissues, which are crucial for understanding processes like embryonic development, tissue regeneration, and metastasis.

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  Bart Alewijnse Programmeur/lab technicus

  Faculteit der Geesteswetenschappen

  b.alewijnse@hum.leidenuniv.nl | 071 5272320

• genes driving tumorigenesis and therapy resistance in human breast cancer Onderzoeksoutput

  To improve cancer treatments, personalized medicine approaches have aimed to identify exactly which mutations are driving tumor development in a given patient and specifically target these mutations using precision therapies.

• Bart Barendregt Dossier: Leiden Teachers’ Academy

  Bart Barendregt ontwikkelt een multimodale, methodologische toolkit.

• Bart Barendregt Dossier: Leiden Teachers’ Academy

  Bart Barendregt ontwikkelt een multimodale, methodologische toolkit.

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  Bart Barendregt Vice-decaan Onderzoek/ hoogleraar Antropologie van digitale diversiteit

  Faculteit der Sociale Wetenschappen

  barendregt@fsw.leidenuniv.nl | +31 71 527 3475

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  Bart Schermer Hoogleraar Recht en Digitale Technologie

  Faculteit Rechtsgeleerdheid

  b.w.schermer@law.leidenuniv.nl | +31 71 527 8838

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  Bart Zantvoort Docent

  Faculteit der Geesteswetenschappen

  f.w.zantvoort@hum.leidenuniv.nl | 071 5272727

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  Bart Roep Hoogleraar Diabetologie, in het bijzonder de immunopathologie van type 1 diabetes mellitus

  Faculteit Geneeskunde

  b.o.roep@lumc.nl | +31 71 526 3869

• Exploring the mechanisms of metastatic onset for novel treatment strategies Onderzoeksoutput

  This thesis represents a comprehensive investigation into the control of cancer stemness and metastatic initiation using a combination of advanced zebrafish xenograft models and in vitro assays.

• Liposome-based synthetic long peptide vaccines for cancer immunotherapy Onderzoeksoutput

  Promotores: Wim Jiskoot; Ferry Ossendorp

• The diverse roles of integrin α3β1 in cancer: Lessons learned from skin and breast carcinogenesis Onderzoeksoutput

  In this thesis, we aim to shed light on the diverse and often opposing roles of integrin α3β1 in cancer.

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  Bart Wielders Promovendus / buiten

  Faculteit Governance and Global Affairs

  b.wielders@fgga.leidenuniv.nl | 070 8009500

• Disrupting the transcriptional machinery to combat triple-negative breast cancer Onderzoeksoutput

  Triple-negative breast cancer (TNBC) is a subtype of breast cancer characterized by limited treatment options and unfavorable clinical outcomes. Therefore, the research described in this thesis focused on the exploration of novel targeted therapies for TNBC.

• Uncovering vulnerabilities in triple-negative breast cancer Onderzoeksoutput

  Triple-negative breast cancer (TNBC) constitutes a small subtype (~15%) of breast cancer, but causes the majority of breast cancer-related deaths.

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  Bart Kramer Promovendus / gast

  Wiskunde en Natuurwetenschappen

  b.kramer@lacdr.leidenuniv.nl | +31 71 527 4220

• Targeted Therapy for Triple-Negative Breast Cancer Onderzoeksoutput

  The research described in this thesis focused on identifying novel drug targets and synergistic combinations for triple-negative breast cancer (TNBC), a virulent subtype of breast cancer with a dismal prognosis and limited therapeutic options.

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  Bart van Horck Buiten promovendus

  Faculteit Governance and Global Affairs

  b.c.a.van.horck@fgga.leidenuniv.nl | +31 70 800 9502

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  Bart van Lieshout Promovendus

  Wiskunde en Natuurwetenschappen

  b.van.lieshout@lacdr.leidenuniv.nl | +31 71 527 6209

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  Bart de Vries Gast

  Faculteit der Sociale Wetenschappen

  h.e.j.de.vries@fsw.leidenuniv.nl | +31 71 527 2727

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  Bart de Jongh Docent

  Faculteit der Sociale Wetenschappen

  b.n.de.jongh@fsw.leidenuniv.nl | 071 5272727

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  Bart van der Wal Hoogleraar Orthopedie

  Faculteit Geneeskunde

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  Bart van der Hoogt Stagiair

  Wiskunde en Natuurwetenschappen