Promotor: Prof.dr. J.N. Kok

Promotor: H.P. Spaink, Co-Promotor: A.H. Meijer

The function of TLRs in innate immunity has aroused worldwide attention soon after its discovery. Because of the broad functions of TLR2 in innate immunity, the drive for the development of TLR2-targeted vaccines or therapeutic treatments has accelerated in the last decades.

The effective treatment of tuberculosis (TB) remains a major challenge to global health.

Promotor: Prof.dr. H.P. Spaink, Co-promotor: Dr. M. van der Zee

Autophagy is a fundamental degradative process, maintaining cellular homeostasis and functions in host defense against intracellular pathogens, including mycobacteria and Salmonella.

Hoe gebruiken ziekteverwekkende mycobacteriën de vetten in onze cellen, en hoe kunnen we dat tegenhouden?

Promotores: Prof.dr. H.P. Spaink & Prof.dr. P.C.W. Hogendoorn Co-promotor: Dr. M.J.M. Schaaf

This thesis focuses on the role of chemokine receptors CXCR3 and CCR2 in the inflammatory process and infection control using the zebrafish model.

Promotores: A.H. Meijer, H.P. Spaink

Hoe helpen lipasen in Mycobacterium tuberculosis de bacterie te overleven, en kunnen we deze enzymen gebruiken als doelwit voor nieuwe antibiotica?

The research described in this Thesis was aimed at designing and synthesizing nature-inspired compounds as part of TB vaccine discovery.

Glucocorticoids (GCs) are widely prescribed as anti-inflammatory drugs due to their well-established immunosuppressive effects.

β-Lactamases are enzymes that can break down β-lactam substrates, such as antibiotics, preventing the use of these antibiotics for the treatment of various infectious diseases. However, some compounds, β-lactamase inhibitors, can block these enzymes allowing for possible treatments using a combination…

Promotor: Prof.dr. H.P. Spaink, Co-promotor: Prof.dr. A.H. Meijer

Enzymes are innately sensitive to changes in the amino acid sequence, which largely constrains their evolutionary potential, i.e., evolvability. This evolutionary burden can be alleviated in the presence of stabilizing mutations, which increase the buffering capacity of enzymes to tolerate mutations…

Promotie

This thesis focuses on two processes involved in fighting infections: metabolism and immune cell motility and navigation.

Josien de Klerk en Tennessee Miller onderzochten de interactie tussen de ziekte- en herstelervaringen van studenten en de academische werkcultuur in deze context.

Promotor: H.P. Spaink, A.H. Meijer Co-promotor: R. Marin-Juez

Promotores: T. Hankemeier; R. Berger, Co-promotor: R.J. Vreeken

BlaC is the β-lactamase of Mycobacterium tuberculosis. We show that it can recover from inhibition by clavulanic acid and that phosphate helps it do so.

In this thesis, bioorthogonal chemistry is combined with correlative light-electron microscopy to selectively label and study pathogenic intracellular bacteria within the host immune cell.

The research described in this thesis has, using the zebrafish as a model system, shed new light on the intricate relationship between TB and DM2, in particular on the role of leptin, SHP-1 and glucocorticoids.

Antimicrobial drugs constitute a fundamental part of modern medicine. The global rise in antimicrobial resistance poses a major threat to global health.

Promotie

Kunnen kleine moleculen het immuunsysteem herstellen en helpen tuberculose te bestrijden door autofagie te stimuleren?

The aim of this thesis was to study phage infection in Streptomyces, focused on cell wall-deficient cells. Bacteriophages (or phages in short) attach to the cell wall of bacteria after which they replicate and lyse the host cell.

Control of infectious diseases poses continuous challenges for human health.

By drawing on the personal experiences of contributors based in different institutions and countries, the articles in this special issue provide a fairly broad overview of ethics practices and concerns in different localities (though not globally, as we had originally hoped), showing, as one student…

Promotor: G.F.A. Kersten, W. Jiskoot, Co-promotor: B. Metz

Promotie

The outbreaks of AIDS and COVID-19 showed clearly how infectious viruses can influence people’s lives. Investigating the changes in the host metabolism may provide a paradigm shift to consider immune-metabolic interactions as therapeutic targets.

Promotor: C.A.M.J.J. van den Hondel, Co-promotor: Sandra de Weert

New drugs for use as tuberculosis (TB) treatment are needed due to the constrains of classical antibiotics against TB and the rise of antibiotic-resistant strains, making TB a harder and harder disease to treat.

Antibiotic resistance, caused by widespread use of antibiotics, leads to bacterial infections that are difficult, if not impossible, to treat and is a major worldwide health concern.

Aspergillus niger is an important industrial producer of organic acids and enzymes producing large amounts of spent fungal biomass.

Promotie

De examencommissie van de Honours Academy stelt vast of de student voldoet aan de eisen van het desbetreffende honoursprogramma en behandelt uitzonderingsverzoeken.

Een onderzoek naar hoe mensen eten en drinken tijdens hun dagelijkse routines, en onder welke omstandigheden dit plaatsvindt.