1,392 zoekresultaten voor “brain development” in de Publieke website
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Predicting the future: Predictive control for astronomical adaptive optics
The field of exoplanet research is rapidly advancing through the development of new technology, observing techniques, and post-processing methods.
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The road to insurmountability: Novel avenues to better target CC Chemokine receptors
This thesis explores different avenues to develop insurmountable antagonists for CC Chemokine Receptors, such as CCR1, CCR2 and CCR5.
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Analysis of Energy Systems
The Institute of Environmental Sciences has carried out and participates in several projects that deal with the analysis of energy systems.
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Synthesis and applications of cell wall glycopolimer fragments from Staphilococci and Enterococci
Carbohydrates are present on the surface of bacteria making them suitable antigen candidates for vaccine development. This thesis deals with the synthesis of two carbohydrate-based components; the capsular polisaccharide of S. aureus type 5 and teichoic acids from staphilococci and enterococci speci…
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Materials Innovative Technologies Assessment (MIN-TEA)
How can prospective LCA be streamlined in a way that its practical application in research and technology development increases?
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Design, synthesis and application of paramagnetic probes for protein structure studies
The main subject of this thesis is the design and synthesis of paramagnetic molecules for protein studies with NMR and EPR spectroscopy.
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Modulation of leukocyte homeostasis in atherosclerosis
Promotores: Prof.dr. E.A.L. Biessen, Prof.dr. T.J.C. van Berkel
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Pharmacology based toxicity assessment: towards quantitative risk prediction in humans
Promotor: Prof.dr. M. Danhof
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Caging ruthenium complexes with non-toxic ligands for photoactivated chemotherapy
The main goal of the research described in this thesis was the development of new photoactivated chemotherapy (PACT) ruthenium(II) complexes bearing a non-toxic photolabile ligand.
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Self-Adjusting Surrogate-Assisted Optimization Techniques for Expensive Constrained Black Box ProblemsBagheri, S.
Optimization tasks in practice have multifaceted challenges as they are often black box, subject to multiple equality and inequality constraints and expensive to evaluate.
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Forces and symmetries in cells and tissues
The way organisms develop from the initial single-cellular state to a complex final assembly like the human body, and how the final body is maintained throughout life, is one of the greatest mysteries and it’s understanding one of the biggest scientific challenges.
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Temminck's Order. Debates on Zoological Classification: 1800-1850
“Temminck’s Order” is the scientific biography of Coenraad Jacob Temminck (1778–1850), a Dutch naturalist and the first director of ’s Rijks Museum van Natuurlijke Historie in Leiden.
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Novel formulations and delivery strategies for inactivated polio vaccines : new routes with benefits
This thesis describes the development of improved formulations and alternative delivery strategies for polio vaccination.
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Synthesis of Ribitol Phosphate based Wall Teichoic acids
Antibiotic resistance, caused by widespread use of antibiotics, leads to bacterial infections that are difficult, if not impossible, to treat and is a major worldwide health concern.
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Onderwijs
De programmagroep Leer- en Gedragsproblemen in het Onderwijs is verantwoordelijk voor onderwijs op het gebied van leerproblemen binnen de bachelor- en masteropleidingen van het Instituut Pedagogische Wetenschappen.
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Inhibitors and activity-based probes for β-D-glucuronidases, heparanases and β-L-arabinofuranosidases
Glycosidases (GHs) are enzymes responsible for the degradation of carbohydrates and play many roles in human health and pathophysiology. Often, abnormal levels of glycosidase activity are markedly linked to human pathologies.
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SDG Report
The following report discusses a survey on the topic of the Sustainable Development Goals that was distributed among researchers at Leiden University in the month of November 2021.
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A pharmacognostic study of Vernonia guineensis Benth. (Asteraceae): bioactivity, safety, and phytochemical analysis
Promotor: Prof.dr. R. Verpoorte, Co-Promotor: Dr. Young Hae Choi
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Biomimetic models of [NiFe] hydrogenase for electrocatalytic hydrogen evolution
The growing demand of energy indicates that global energy resources in the form of fossil fuels will not be sufficient in the future. In order to solve potential future energy problems development of a sustainable hydrogen economy is highly desirable.
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Sensing Transport
Solute carrier (SLC) transporters are a large and diverse class of relatively understudied transmembrane proteins.
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Visualization of Vitamin A Metabolism
Vitamin A or retinol is essential in embryonic development, the visual cycle and the immune system.
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Exploring novel regulators and enzymes in salicylic acid-mediated plant defense
Salicylic acid (SA) is a plant hormone, which is involved in the defense responses to pathogens and to abiotic stress, and in the regulation of plant growth and development.
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Allosteric modulation and ligand binding kinetics at the Kv11.1 channel
Promotor: Prof.dr. A.P. IJzerman, Co-Promotor: L.H. Heitman
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The role of the Arabidopsis AHL15/REJUVENATOR gene in developmental phase transitions
This thesis describes the functional analysis of the Arabidopsis AHL15 gene.
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Affinity-based profiling of the adenosine receptors
The adenosine receptors are proteins that reside in the extracellular membranes of cells. Activation of adenosine receptors plays a role in many physiological and pathological processes, such as immune responses and cancers.
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Discovery of Reversible Monoacylglycerol Lipase Inhibitors
Monoacylglycerol lipase (MAGL) is the principal enzyme responsible for hydrolysis of the endocannabinoid 2-arachidonoylglycerol (2-AG). MAGL inhibition provides several potential therapeutic opportunities, including anti-nociceptive, anti-inflammatory and anti-cancer activity.
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Systems pharmacology of the endocannabinoid system
In this thesis, a system pharmacology approach, integrating metabolomics, pharmacology and chemical biology, was applied to understand and modulate the endocannabinoid system across different model systems (cells, zebrafish, mice and humans).
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Onderwijs
In het academisch jaar 2023-2024 biedt het interdisciplinaire onderzoeksprogramma Sociale Veerkracht en Veiligheid vier vakken aan voor studenten die beginnen met het derde jaar van hun bachelor. Deze vakken zijn te volgen binnen de ruimte voor keuzevakken. Je kunt de vakken afzonderlijk als keuzevak…
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Pre- and perinatal risk factors
Effects of maternal smoking, premature birth, intra-uterine growth retardation and asphyxia on child development.
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Probing quantum materials with novel scanning tunneling microscopy techniques
This thesis described the development of novel scanning tunneling microscopy techniques to investigate strongly correlated electronic states in quantum matter.
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Sociology of Policy in Practice (MSc)
De masterspecialisatie Sociology of Policy in Practice biedt de mogelijkheid om een onderzoeksstage te doen om het beleid van een bedrijf of organisatie in de praktijk te bestuderen..
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Visual Ethnography (MSc)
In de masterspecialisatie Visual Ethnography leer je de kneepjes van het vak om etnografisch onderzoek met audiovisuele methodes te doen.
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Computational Approaches to Disease, Signaling and Drug Targets
The Minor Computational Approaches to Disease, Signaling and Drug Targets (CADSDT) is focused on fundamental scientific research required for discovery of new drug targets and development of new drugs.
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Contact
Wij zijn gevestigd in het Pieter de la Courtgebouw van de Faculteit der Sociale Wetenschappen van de Universiteit Leiden.
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NWO-beurs drijft zoektocht naar duurzame productie antibiotica
De kans om een nieuw, spannend onderwerp te onderzoeken. Dat is hoe Lennart Schada von Borzyskowski zijn succesvolle beursaanvraag voor de NWO XS-beurs noemt. Deze 50.000 euro zal de onderzoeker van het Instituut Biologie Leiden (IBL) spenderen aan het ontwikkelen van een nieuwe methode om op duurzame…
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EUniWell Open Lecture Series | From knowledge transfer to personal development
Lezing, Lezing onderdeel van serie
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Emerging Powers and Development Finance across the World
Debat, Roundtable
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The Sand Motor - Building with Nature to optimise coastal protection and other ecosystem services
How can mega sand nourishments, such as the Sand Motor, be designed and managed for optimal ecosystem services provision ?
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Brein en gedrag in ontwikkeling
Hoe meer mogelijkheden een kind krijgt om te leren en zich te ontwikkelen, hoe sterker zijn of haar positie in de maatschappij zal zijn. De Universiteit Leiden onderzoekt hoe de hersenen informatie oppakken, en hoe leerprocessen positief kunnen worden beïnvloed.
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Diploma-uitreiking master programme Cultural Anthropology and Development Sociology
Festival, Diploma-uitreiking
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Big Data in ontwikkelings- en humanitaire hulp: een volgende stap in het privacydebat
Hoe kan ‘Big Data’ worden ingezet bij ontwikkelings- en humanitaire hulp en wat zijn de risico’s daarvan? De Universiteit Leiden en United Nation’s Global Pulse organiseren hierover op 23 oktober in Den Haag een internationale expert meeting.
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Osteoprotegerin, a double-edged sword in osteoarthritis development
Promotie
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Diploma-uitreiking master Cultural Anthropology and Development Sociology
Festival, Diploma-uitreiking
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Towards the development of synthetic vaccines against tuberculosis
Promotie
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Bone and joint disorders: Screening and early clinical drug development
Promotie
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Clinically Suspect Arthralgia, Unraveling the Development of Rheumatoid Arthritis
Promotie
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Calcium-dependent regulation of auxin transport in plant development
Promotie
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Development of nanoparticulate adjuvants based on aluminium salts
Promotie
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Zij maken binnenkort een paraboolvlucht (en jij kunt mee)
Altijd al eens gewichtloos willen zijn? Dit is je kans! Een Nederlands studententeam gaat in december 2017 experimenten doen tijdens een paraboolvlucht, en ze zoeken nog gezonde vrijwilligers. Je moet wel aan een aantal strenge eisen voldoen, zegt de Leidse teamleider.
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Leidse sterrenkundigen schrijven IEEE Software Impact column
De eer was aan Professor Simon Portegies Zwart en doctor Jeroen Bédorf om voor het blad IEEE Software te schrijven.