De progressie van menselijke ziekten als kanker en TBC is goed te bestuderen in larven van zebravissen. Met robots en automatische herkenning van microscopische beelden gaan bioloog Herman Spaink en informaticus Fons Verbeek uitzonderlijk snel het effect van nieuwe medicijnen testen. De aanschaf van…

A complex community of microbes develops in the infant gut shortly after birth. We call this community the infant gut microbiota. The microbiota influences the health of the infant, which makes the composition and function of the infant gut microbiota an important topic to study.

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Sterrewacht Leiden is het sterrenkundig instituut van de Faculteit der Wiskunde en Natuurwetenschappen van de Universiteit Leiden.

With increasing carbon dioxide levels in the atmosphere and their detrimental effect on the global climate, modern society needs to push for more renewable energy sources. Storing widely accessible and abundant solar energy in chemical bonds in the form of molecular fuel via artificial photosynthesis…

This thesis focuses on data found in the field of computational drug discovery. New insight can be obtained by applying machine learning in various ways and in a variety of domains. Two studies delved into the application of proteochemometrics (PCM), a machine learning technique that can be used to…

Simulaties van sterrenstelsels helpen om astronomische waarnemingen beter te begrijpen. De EAGLE simulatie, een groot project waarin Leidse astronomen een hoofdrol hebben, laat de evolutie van het heelal zien, van vlak na de Oerknal tot nu.

Na de conferentie van de 20e Oostenrijkse Dag van het Europees recht in september 2021 aan de Universiteit van Liechtenstein in Vaduz, zijn de academische papers van de conferentie nu in boekvorm gepubliceerd. Tot de bijdragen aan het boek behoort een hoofdstuk van Christa Tobler: Christa Tobler, ‘Finally…

Handbook of Signal Processing Systems is organized in four parts. The first part motivates representative applications that drive and apply state-of-the art methods for design and implementation of signal processing systems; the second part discusses architectures for implementing these applications;…

Viral diseases constitute one of the major challenges in modern medicine. Membrane-targeting have broad-spectrum potential and could distinguish viral membranes from the host cell plasma membrane by the difference in membrane curvature.

Promotores: Prof.dr. J. Schaye, Prof.dr. S.D.M. White (MPA Garching)

Computers van wetenschappers staan inmiddels vol met ingewikkelde 3D-modellen, maar voor de uitwisseling van de gegevens is nog geen standaard ontwikkeld. Een nieuwe database moet daar verandering in brengen. Buitenpromovendus Liselore Tissen ontvangt een beurs om er namens Universiteit Leiden (en TU…

In meta-analysis, heterogeneity often exists between studies. In such cases, it is essential to investigate the sources of heterogeneity and understand the relationship between effect size and study characteristics (i.e., moderators).

Invasive lobular carcinoma (ILC) is the second most common type of breast cancer.

Promotores: Prof.dr. W.J.G.M. Peijnenburg & Dr. M.G. Vijver

Schenden AI-modellen zoals Midjourney het auteursrecht van kunstenaars? Dirk Visser, hoogleraar Intellectueel Eigendomsrecht, sprak met NOS Radio 1 Journaal over dit onderwerp.

This thesis is based on five papers on several topics.

The development process of any software has become extremely important not just in the IT industry, but in almost every business or domain of research.

The 2019 Model ICAO took place from 21-24 May at the ICAO headquarters in Montreal.

Aim: To develop and enable application of a practical, flexible, user-friendly platform to provide the scientific community with a tool to generate land surface products and its associated uncertainties and exploit these for data-intensive science.

Which traits and/or trade-offs determine benefits of being deciduous or evergreen?

In the traditional theory of linear elasticity, superposition dictates that the response of a material does not depend on the sequence of the applied mechanical actuations.

Gold nanorods are biocompatible nanoparticles that present an excellent two-photon signal that can be used to get high spatial resolution inside living cells. Gold nanorods are photostable and therefore can be followed inside cells for long time, with possible applications as trackers in live cells.

This thesis introduces the concept of

Biological cells, the basic building blocks of all life forms, are surrounded by a lipid membrane. More than half of the membrane is occupied by membrane proteins, which can regulate the cell functionality through specific arrangements.

Acute cardiovascular clinical events such as myocardial infarction and cerebral stroke represent the major cause of death in Western societies. These pathologies are primarily resulting from atherosclerosis, a progressive condition characterized by the accumulation of lipids, immune cells, and fibrous…

Stochastic resetting is simple enough to be approached analytically, yet modifies stochastic processes in a non-trivial way.

This thesis describes the importance of being able to control the selectivity of potential drug candidates.

Promotor: F.S. de Boer Co-promotor: P. T. de Gouw

Promotor: M. Ubbink, Co-promotor: G. Siegal

In my thesis I study Majorana fermions from three different perspectives. The first one corresponds to non-interacting Majorana fermions that, however, pose non-trivial topological properties. The second one corresponds to strongly interacting Majoranas and the third to relic neutrinos. No one knows…

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What are the behaviours of plant traits throughout various points in the growing season in a radiative transfer model framework and how well can this knowledge be integrated through data assimilation to provide priors for robust local and global vegetation products and analysis?

Inactivating mutations in BRCA1 or BRCA2 genes predispose to several types of cancer.

Marokko is een van de weinige landen in Noord-Afrika die aan de Arabische lente een vreedzame vorm heeft weten te geven door het pad van brede, gestage politieke hervormingen op te gaan. De Marokkaanse overheid verklaart de relatieve maatschappelijke rust daarnaast ook door haar islampolitiek, gericht…

Glucocorticoids (GCs) are widely prescribed as anti-inflammatory drugs due to their well-established immunosuppressive effects.

Computerwetenschapper Tim Coopmans gebruikt pen, papier en gewone computers om de best mogelijke quantumcomputer te simuleren. Hij vertelt over zijn onderzoek en hoe dit helpt om een bruikbare quantumcomputer sneller werkelijkheid te maken. ‘Ik hoop dat ik zal meemaken dat quantumcomputers echt iets…

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