Thesis focused on uncovering the underlying mechanisms of the lysosomal storage disorders Gaucher's disease using chemical tools, biochemical assays and lipidomics.

This thesis is devoted to an in-depth examination of the various effects of disorder in the cuprate high-temperature superconductors.

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Lysosomal storage disorders (LSDs) are a group of orphan diseases characterized by lysosomal dysfunction or impaired lysosomal catabolism and affect collectively about 1 in 5000 live births.

Lysosomal glycosidases are acid hydrolases that fragment glycoconjugates in lysosomes.

Neurodegenerative diseases pose a large medical and societal challenge. The etiology of these diseases is still poorly understood, which makes drug discovery for these diseases difficult.

The research described in this thesis combines the latest insights in lysosomal function with lysosome centred cell signalling.

Vanuit het LUBEC bieden wij de mogelijkheid om stage te lopen voor studenten van de master-opleidingen Psychologie of Pedagogiek, bij de afdeling Kind en Jeugd.

Advanced mass spectrometry of glycosphingolipids takes the central stage in this thesis. Investigations focus on characterization of glycosphingolipid metabolism in health and disease with emphasis to the detection and accurate quantitation of known and so far unknown glycosphingolipids and closely…

Emoties en de psychosociale ontwikkeling van kinderen met en zonder Taal Ontwikkelingsstoornis

Promotores: H.S. Overkleeft, G.A. van der Marel, Co-promotor: B.I. Florea

The lysosomal β-glucosidase named glucocerebrosidase (GCase) is a retaining β-glucosidase that hydrolyzes the glycosphingolipid glucosylceramide (GlcCer) to ceramide and glucose at acid pH.

N-acylethanolamines (NAEs), including N-arachidonoylethanolamine (anandamide, AEA), N-palmitoylethanolamine (PEA) and N-oleoylethanolamine (OEA), are signaling lipids that play an important role in different physiological process.

The studies described in this thesis deal with glycosidases, in particular alpha-galactosidases.

The research described in this thesis has, using the zebrafish as a model system, shed new light on the intricate relationship between TB and DM2, in particular on the role of leptin, SHP-1 and glucocorticoids.

Glycosidases are essential in fundamental biological processes and are responsible for the degradation of most (oligo)saccharides, glycolipids and glycoproteins.

The main aim of my Ph.D. thesis is to further explore the value of using early developing zebrafish larvae (up to 5 dpf) as a model to study anxiety-like behaviour and their pharmacological modulation with drugs.

To address the fundamental questions of how life on Earth emerged and how common life may be in the Universe, it is crucial to know the chemical composition of the planet-forming material.

Announcement of the publication of Vamping the Stage: Female Voices of Asian Modernities, the first book-length study of women, modernity, and popular music in Asia (University of Hawai'i Press, 2017).

Een aantal boeren en uitwisselingsinstantie SUSP, wordt beticht van misleiding bij inzetten buitenlandse stagiairs. De agrarische bedrijven zouden de stagiairs te veel hebben laten werken, i.p.v. een stage aan te bieden. De arbeidsinspectie heeft aangekondigd deze bedrijven en instantie een boete op…

Promotor: Prof.dr. C.W.J. Beenakker

Promotor: Prof.dr. J. den Hertog

Hoewel de meerwaarde van stages in het bedrijfsleven in eerder onderzoek wordt onderschreven, is er nog niet veel bekend over hoe het leren van docenten tijdens hun stage plaatsvindt en hoe zij hun leerervaringen uit stages gebruiken voor hun nderwijs. Om een meer diepgaand inzicht te verkrijgen in…

Als gevolg van de grote technologische vooruitgang in de gezondheidszorg worden in toenemende mate gegevens verzameld tijdens de uitvoering van klinische onderzoeken.

The investigation into the bidirectional communication between the gut and its host is a rapidly growing area of research, attracting considerable attention for its potential to provide crucial insights into health and disease.

A dense region of a gaseous and dusty cloud collapses to form a protostar surrounded by a disk and an envelope. This thesis uses both observations and models to study physical and chemical conditions of these protostellar systems which are likely where planets start to form.

Wat beïnvloedt het gedrag van verantwoordingsforums?

Promotie

The ideas underlying this thesis are that lipidomics may improve the diagnosis of liver metabolic diseases, and can provide further insights into the underlying pathophysiology of these diseases.

Optimalisatie, werkingsmechanismen en voorspellers van het resultaat van lichttherapie bij depressie: Een multicenter gerandomiseerde trial

The research described in this thesis centered on retaining exo-β-glucosidases implicated in health and disease, in particular the human inherited lysosomal storage disorder, Gaucher disease (GD).

This thesis describes biochemical investigations of glucocerebrosidase (GBA), the lysosomal β- glucosidase that is deficient in Gaucher disease (GD).

Het is beter voor studenten en organisaties als stages langer dan twee maanden mogen duren en ook in deeltijd kunnen worden gedaan. Dat was een van de suggesties tijdens de bijeenkomst Leiden University Meets/Needs Employers op 27 juni 2017.

The long-held desire - to link structure directly to function and to explain molecular mechanisms based on basic chemical or physical principles - is finally coming closer, satisfying not only our scientific curiosity but also offering new solutions to the many challenges in the field of health, energy…

Clinical development of drugs for central nervous system (CNS) disorders has been particularly challenging and still suffers from high attrition rates.

In de lezingencyclus Recht en Bedrijf hielden Gerard Bakker, directeur Mededinging bij de Nederlandse Mededingingsautoriteit (NMa), en Edwin van Dijk, Hoofd Recherche en Inlichtingen, een lezing over Marktwerking en Mededinging. Bakker en Van Dijk hadden een stageplek in het vooruitzicht gesteld voor…

This Thesis describes the design, synthesis and evaluation as glycoprocessing enzyme inhibitors of focused libraries of iminosugars.

Samen met wetenschappers van over de hele wereld streeft de ENIGMA-Anxiety Werkgroep ernaar om meer inzicht te krijgen in de neurobiologische karakteristieken van angststoornissen.

In this thesis, bioorthogonal chemistry is combined with correlative light-electron microscopy to selectively label and study pathogenic intracellular bacteria within the host immune cell.

The effective treatment of tuberculosis (TB) remains a major challenge to global health.

Control of infectious diseases poses continuous challenges for human health.

Glycoside hydrolases (glycosidases/GHs) are widely abundant enzymes in all kingdoms of life and are important biocatalysts that catalyze the hydrolysis of glycosidic linkages in oligo/polysaccharides, glycoproteins and glycolipids with tremendous efficiency

The aims of the project are to: further clarify 'inhibition by safety'; explore and describe all possible sagety factors, with a special focus on the primary human safety source: social connectedness; reviewing prolonged stress responses without stressors.

Een lijst met wetenschappelijke publicaties samengesteld door het team van het TRIXY Expertisecentrum.