Het ontwerp voor het METIS-instrument voor de Extremely Large Telescope (ELT) is definitief. De Europese Zuidelijke Sterrenwacht (ESO) heeft groen licht gegeven voor de productie van alle onderdelen van het instrument. Het is het eerste ELT-instrument, ontworpen en te bouwen onder Nederlandse leiding,…

Quantum hardware comes with a different computing paradigm and new ways to tackle applications. Much effort has to be put into understanding how to leverage this technology to give real-world advantages in areas of interest for industries such as combinatorial optimization or machine learning.

Het METIS-instrument dat onder leiding van de Nederlandse Onderzoekschool voor Astronomie (NOVA) wordt gebouwd voor ESO's toekomstige Extremely Large Telescope (ELT) in Noord-Chili heeft een belangrijke mijlpaal bereikt: het voorlopig ontwerp is goedgekeurd.

Glycoconjugate vaccines are composed of microbial poly- or oligosaccharides covalently linked to a carrier protein.

The path to rational drug and dose selection

Nanoparticles can be used as delivery systems for both small molecules and macromolecules such as proteins, peptides or oligonucleotides. This thesis focuses on the use of liposomes, nanometric vesicles formed by a lipid bilayer enclosing an aqueous core. Liposomes are highly versatile delivery syst…

The explosive radiation and diversification of the advanced snakes (superfamily Colubroidea) was associated with changes in all aspects of the shared venom system. Morphological changes included the partitioning of the mixed ancestral glands into two discrete glands devoted for production of venom ormucous…

Op 15 april promoveert Shaoyu Wang. Het Leiden University Centre for Linguistics feliciteert Shaoyu!

For optimization problems, it is often unclear how to choose the most appropriate optimization algorithm. As such, rigorous benchmarking practices are critical to ensure we can gain as much insight into the strengths and weaknesses of these types of algorithms.

Promotor: P.D. Grünwald

Promotores: H.A. Udo de Haes, H.H.T. Prins, Co-promotor: H.H. de Iongh

Taxonomy as a science has accumulated data and knowledge for more than 250 years.

Promotor: M.K. Richardson, Co-Promotor: F. Witte

Streptomyces are filamentous bacteria that produce more than two-thirds of known antibiotics.

The research aims to explore the evolutionary adaptability of enzymes and the impact of temperature on protein evolution pathways, using M. tuberculosis β-lactamase BlaC as the object of study. Enzymes inherently embody a delicate balance between activity and stability, and the acquisition of new enzymatic…

Hieronder vind je de antwoorden op een aantal veelgestelde vragen over toelating tot de klinische specialisaties van de Master Psychologie.

In this thesis we investigate cosmology and the large scale structure of the Universe using cosmological simulations.

This thesis investigates how quantum, quantum-inspired, and hybrid quantum-classical computation can enhance key points of the automated machine learning (AutoML) pipeline under the constraints of noisy intermediate-scale quantum (NISQ) devices.

This thesis focuses on important life history traits and their trade-offs using two hexapod models. Particularly, the trade-off between immune defense and embryonic developmental speed is a central theme of this study.

Promotor: P.G.L. Klinkhamer, Co-Promotores: K. Vrieling, P.P.J. Mulder

This thesis involves three topics: benchmarking discrete optimization algorithms, empirical analyses of evolutionary computation, and automatic algorithm configuration.

Bernhard Brandl, de nieuwe Leidse hoogleraar Infraroodastronomie, bouwt mee aan instrumenten waarmee de grootste telescopen ter wereld worden uitgerust. Met die telescopen kan de mens in het heelal objecten observeren die soms meer dan dertien miljard jaar oud zijn. Op 26 september houdt Brandl zijn…

Chapter 2 describes a post-synthetic methodology to introduce a fluorescent label in highly lipophilic, Pam3Cys based conjugates.

Promotor: A.W. van der Vaart

During the course of drug discovery translational steps are made.

The focus of this thesis is on the technical methods which help promote the movement towards Trustworthy AI, specifically within the Inspectorate of the Netherlands.

Studievoorlichting, Online Experience

Studievoorlichting, Online Experience

There is an urgent need for more physiologically relevant cell culture methods to guide compound selection in pre-clinical stages of the drug development pipeline.

Predictive maintenance (PdM) is a maintenance policy that uses the past, current, and prognosticated health condition of an asset to predict when timely maintenance should occur.

The increasing resistance of pathogenic bacteria to antibiotics necessitates the discovery of new medicines.

Drug-induced liver injury (DILI) is one of the main reasons for drug attrition during pre-clinical and clinical phases of drug development as well as for drug withdrawal post-marketing.

In this thesis, we use low-frequency and high-frequency radio observations to address the following questions regarding quasars: is the radio loud/quiet quasar dichotomy real?

In this work, I explore the creation of new methods that optimize simulations of the gravitational N-body problem. Specifically, I take advantage of the recent popularity of Machine Learning methods to find tools that can suit this problem.

It is a common technique in global optimization with expensive black-box functions to learn a surrogate-model of the response function from past evaluations and use it to decide on the location of future evaluations.

Promotor: Prof.dr. T.H.W. Bäck

Promotor: Prof.dr. P.G.L Klinkhamer, Co-promotor: K. Vrieling

In this PhD-thesis several new and existing data science application are described that are particularly focused on applications for tax administrations.

The main research question of this thesis was: Can nitrogen cycling on dairy farms on peat soil in the Dutch Green Heart area be improved by adapting management to the nitrogen supply from soil and by using other grassland species and crops without affecting milk production?

Leidse wetenschappers gaan een bijdrage leveren aan de ontwikkeling van een camera voor de in aanbouw zijnde European Extremely Large Telescope. Op 28 september tekende de Nederlandse Onderzoekschool voor Astronomie een samenwerkingsovereenkomst met de European Southern Observatory.

In this thesis, mathematical modeling and simulation was applied as a tool to inform quantitative decision making in oncology drug discovery and development.

Learning from small data sets in machine learning is a crucial challenge, especially when dealing with data imbalances and anomaly detection. This thesis delves into the challenges and methodologies of learning from small datasets in machine learning, with a particular focus on addressing data imbalances…

To gain more insight into the evolutionary development of orchid flowers and fruits, the orchid species Erycina pusilla was studied. The evolutionary origin of the median petaloid sepal, the callus on the labellum, and the stelidia was studied.

Na jaren van ontwikkeling is het moment eindelijk daar: een enorme cryostaat, een bijzonder geavanceerde vriezer die de gevoelige onderdelen extreem koud houdt, is vanuit Zürich in Leiden aangekomen. Het apparaat is het grootste onderdeel van METIS, een van de eerste instrumenten op ESO’s Extremely…

Promotor: P.M. Brakefield

We have examined sequences from the ligand-binding domain of the nicotinic acetyl choline receptor (nAChR) in 148 vertebrate species. We are in interested in this receptor because the α-neurotoxins of many venomous snakes binds to this receptor in its location at the neuromuscular junction in all ve…

Promotie