In this thesis, we have used numerical approaches to study the effects of translational symmetry breaking on strange metallic systems as realised by the holographic duality⁠.

The zebrafish is a promising vertebrate model organism in early drug discovery and development.

Promotie

Promotie

The studies presented in the work show the potential of the integrative use of biophysical data in defining the structural basis of protein interactions.

In this thesis, mathematical modeling and simulation was applied as a tool to inform quantitative decision making in oncology drug discovery and development.

Promotor: G. A. van der Marel, Co-promotor: D. V. Filippov

During the course of drug discovery translational steps are made.

This thesis explored the molecular pharmacological mechanisms of targeting CB2R via investigation of novel drug discovery concepts such as target binding kinetics, allosteric modulation and biased signaling.

Hoe werken post-translationele eiwitmodificaties—chemische veranderingen van eiwitten nadat ze zijn gemaakt—samen om DNA te herstellen, en hoe kan dit ons helpen ziektes te begrijpen?

Growth hormone profiles are pulsatile and highly variable between individuals, limiting the implementation of mathemathical models to quantify an individual's secretion.

Healthy aging is one of the prime goals in today's society and atherosclerosis is among the greatest causes of morbidity in elderly. Cardiovascular disease patients receiving treatment are often of advanced aged and have an aged immune system, which limits translating experimental findings to the pa…

The human body consists of hundreds, perhaps thousands of different types of cells, each with different morphologies and functions, despite having the same genome.

Promotores: Prof.dr. H.P. Spaink & Prof.dr. P.C.W. Hogendoorn Co-promotor: Dr. M.J.M. Schaaf

This thesis focuses on enhancing predictions of central nervous system drug exposure using the LeiCNS-PK3.0, a physiologically based pharmacokinetic model.

The research described in this thesis focused on the use of bioorthogonal antigens to investigate immunological processes in antigen presenting cells. Bioorthogonal antigens are antigenic proteins produced through recombinant expression in a methionine auxotrophic E. coli strain.

Regeneration is the ability of an organism to restore damaged or lost tissue with a functional replacement, and without scarring. Many lizards can regenerate their tails.

Promotors: Prof.dr. P.J. Punt, Prof.dr. C.A.M.J.J. van den Hondel

This thesis investigates a pharmacological challenge model induced by Toll-like receptor 7 (TLR7) activation, focusing on skin inflammation and its implications for early drug development.

The plant hormone auxin plays a central role in the growth and development of plants. Auxin acts in a concentration dependent manner and polar cell-to-cell transport of this hormone determines its distribution in the tissues of plants. This polar auxin transport is mediated by several families of auxin…

Sepsis is a life-threatening condition caused by a dysregulated host response to infection, it is associated with significant morbidity, mortality, and with a high financial burden on global healthcare systems. Bacterial infections are the primary cause of sepsis, but the growing prevalence of antimicrobial…

Promotor: A. Doelman, Co-promotor: J.D.M. Rademacher

Discovery and development of Central Nervous System (CNS) drugs is hampered by high attrition rates.

Adenosine diphosphate ribosylation (ADP-ribosylation) is a fascinating post-translational modification (PTM) that plays a role in a variety of cellular processes and is associated with several diseases, including cancer and viral infections.

This thesis seeks to investigate how cancer-associated mutations affect the pharmacological properties of selected GPCRs—primarily A2AAR and 5-HT2CR—through a combination of ligand binding assays, signaling readouts, kinetic profiling, and cellular functional assays.

RARE-NL, een nieuw samenwerkingsverband van diverse universitaire ziekenhuizen, gaat op zoek naar behandelingen voor zeldzame ziekten. Namens het LUMC neemt hoogleraar Teun van Gelder deel aan het initiatief.

Promotie

Promotie

Hans Ulrich Scherer, Leidse hoogleraar translationele reumatologie, staat met zijn ene been in de kliniek, waar hij patiënten helpt. Daarnaast begeleidt hij onderzoekers in het laboratorium. In zijn zoektocht naar reumatische auto-immuunziektes slaat hij een brug tussen beide werelden.

Een doorlopende leerlijn suïcidepreventie biedt psychologiestudenten essentiële kennis en vaardigheden om suïcidaliteit effectief te herkennen en het gesprek erover aan te gaan.