1,440 zoekresultaten voor “3d modelling” in de Publieke website
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Phenotypic screening with 3D cell-based assays
Traditional drug discovery approaches have been hampered by (in vitro) cell-culture models that poorly represent the situation in the human body.
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Modeling vascular disease using self-assembling human induced pluripotent stem cell derivatives in 3D vessels-on-chip
Promotie
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Advanced in vitro models for studying drug induced toxicity
Promotor: B.van de Water, Co-promotor: L.S.Price
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Identification of novel targets in prostate cancer progression
Promotor: B. van de Water, Co-promotor: E.H.J. Danen
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Microfluidic 3D cell culture for high throughput screening
There is an urgent need for more physiologically relevant cell culture methods to guide compound selection in pre-clinical stages of the drug development pipeline.
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Computational modeling of mycobacterium infection and innate immune reponse in zebrafish
Promotor: Prof.dr. J.N. Kok
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Development of a Kidney-on-a-Chip Model for Compound Screening and Transport Studies
Pharmaceutical companies, governments and the general public have become increasingly aware that animal models used in drug testing lack vital aspects to serve as an accurate representation of human biology. As models of the human body should become more physiologically relevant, animal models no longer…
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Learning-based Representations of High-dimensional CAE Models for Automotive Design Optimization
In design optimization problems, engineers typically handcraft design representations based on personal expertise, which leaves a fingerprint of the user experience in the optimization data. Thus, learning this notion of experience as transferrable design features has potential to improve the performance…
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Squaramide-based supramolecular materials for 3D cell culture applications
A new type of tripodal squaramide-based supramolecular hydrogels is developed and studied.
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Computational optimisation of optical projection tomography for 3D image analysis
Optical projection tomography (OPT) is a tomographic 3D imaging technique used for specimens in the millimetre scale.
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Biological model representation and analysis
Promotor: Prof.dr. J.N. Kok, Co-promotor: F.J. Verbeek
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Laboratoria Digital Archaeology
De onderzoeksgroep Digital Archaeology beheert twee computerlaboratoria voor verschillende doeleinden: een onderwijslab en een onderzoekslab.
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Abstract Behavioral Specification: unifying modeling and programming
We strive to address the challenge of constructing a modeling language to write software which can take advantage of recent hardware developments (multicore, cloud) without compromising in its abstraction levels.
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Computational modeling of angiogenesis : from matrix invasion to lumen formation
Promotor: Roeland M.H. Merks
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3D structuur van biomoleculen bekijken
Professor Jan Pieter Abrahams gaat onderzoek doen naar de 3D structuur van biomoleculen om uiteindelijk ziektes als tuberculose, malaria en kanker beter te kunnen begrijpen. Hiervoor heeft de Technologiestichting STW een subsidie toegekend van € 25.000,-
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Biotic ligand models
Description of Biotic ligand models: making an inventory of available models & assessment of the variability of the predicted HC5 using the BLMs in different Dutch water types (2005 - 2007)
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Shape Analysis for Phenotype Characterisation from High-throughput Imaging
We have studied shape with a particular focus on the zebrafish model system. The shape is an essential appearance of the phenotype of a biological specimen and it can be used to read out a current state or response or to study gene expression.
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Computational modeling of cellular dynamics in tumor cell migration
Epithelial-mesenchymal plasticity (EMP) and tumor cell migration play an important role in cancer progression, and an improved understanding of the mechanisms underlying these concepts is essential for developing new targeted approaches.
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PhD Competence Model
In 2016 hebben Universitaire Medische Centra (UMC's) van Nederland de zelfevaluatie-tool ontwikkeld gebaseerd op het PhD Competence Model. Onze partners van de Universiteit Utrecht stellen een digitale versie van de tool kosteloos beschikbaar voor onze promovendi binnen de Universiteit Leiden, ook voor…
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Unraveling temporal processes using probabilistic graphical models
Real-life processes are characterized by dynamics involving time. Examples are walking, sleeping, disease progress in medical treatment, and events in a workflow.
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Adaptive Streaming Applications: Analysis and Implementation Models
Promotor: Prof.dr. E. Deprettere
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Harnessing zebrafish xenograft models for ocular melanoma treatment discovery
The aim of this thesis was to develop novel treatment strategies for different types of eye melanoma utilizing zebrafish models. We first establish orthotopic and ectopic xenograft models for uveal and conjunctival melanoma by engraftment of the immortalized cells derived from these tumors into zebrafish…
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Casting light on the ƞ Carinae puzzle
Promotor: Prof.dr. V. Icke, Co-Promotor: T.I. Madura
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Model schilderen met diverse technieken
Kunst en vrije tijd, Kunst en vrije tijd
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Promovendus maakt volledig werkend 3D-model van de lever
De Leidse promovendus Sreenivasa Ramaiahgari ontwikkelde voor het eerst een 3D-model van de lever. Zijn model kan een hoop besparen: schade bij patiënten, dierenleed en veel geld. Promotie 4 juni.
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In vivo modelling of Ewing sarcoma in zebrafish
Promotores: Prof.dr. P.C.W. Hogendoorn & Prof.dr. H.P. Spaink Co-promotor: Dr. B.E. Snaar-Jagalska
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Modelling metastatic melanoma in zebrafish
Death in all types of melanomas is generally caused by metastasis. Uveal melanoma (UM) is the most common intraocular melanoma, there are currently no (patient-derived) animal models that faithfully recapitulate metastatic dissemination of UM.
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Bayesian Inference for Gaussian Models
This dissertation studies the Asymptotics of Bayesian nonparametric inference for Gaussian linear models.
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Data Driven Modeling & Optimization of Industrial Processes
Industrial manufacturing processes, such as the production of steel or the stamping of car body parts, are complex semi-batch processes with many process steps, machine parameters and quality indicators.
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Modelling the role of cytotoxic T lymphocytes in tumour regression
Immunotherapies for cancer are an emerging class of therapeutic strategies which aim to treat cancer via augmentation of the immune system.
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Systems pharmacokinetic models to the prediction of local CNS drug concentrations in human
Clinical development of drugs for central nervous system (CNS) disorders has been particularly challenging and still suffers from high attrition rates.
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Precision modeling of breast cancer in the CRISPR era
The molecular mechanisms that instigate a healthy cell to become malignant are fueled by (epi)genetic alterations in so-called driver genes.
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Statistical modelling of time-varying covariates for survival data
This dissertation focuses on developing new mathematical and statistical methods to properly represent time-varying covariates and model them within the context of time-to-event analysis.
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3D modeling and RNA-based therapeutics for Dutch-type Cerebral amyloid angiopathy
Promotie
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LTA lunchlezing: Stuur je even een 3-D model?
Lezing
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Abstract delta modeling: software product lines and beyond
Promotor: Prof.dr. F.S. de Boer, Co-promotor: D. Clarke
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Evaluation of the zebrafish embryo as an alternative model for hepatotoxicity testing
Promotor: Prof.dr. B. van de Water, Co-promotores: L.T.M. van der Ven, A.S. Kienhuis
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Development of a Dynamic Substance Stock Model
Making a dynamic substance stock model in order to conduct scenario analyses and make forecasts.
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Quantitative modelling of the response of earthworms to metals
Promotor: Prof.dr. W.J.G.M. Peijnenburg
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On metrics and models for multiplex networks
In this thesis, we extend the concept of null models as canonical ensembles of multi-graphs with given constraints and present new metrics able to characterize real-world layered systems based on their correlation patterns.
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Imaging complex model catalysts in action
From surface science towards industrial practice using high-pressure scanning tunneling microscopy.
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Statistiek als je modellen niet kloppen
Peter Grunwald
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Postdoc Computational Modeling for Drug Safety Prediction
Wiskunde en Natuurwetenschappen, Leiden Academic Centre for Drug Research (LACDR)
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Synthetic model microswimmers near walls
Synthetic microswimmers take an important place within the interdisciplinary field of active soft matter.
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Zebrafish as vertebrate model of Gaucher disease
Lysosomal storage disorders (LSDs) are a group of orphan diseases characterized by lysosomal dysfunction or impaired lysosomal catabolism and affect collectively about 1 in 5000 live births.
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Quantitative systems pharmacology modeling of biotherapeutics in oncology
In this thesis, mathematical modeling and simulation was applied as a tool to inform quantitative decision making in oncology drug discovery and development.
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Spatiotemporal building stock modeling for residential decarbonization in the Netherlands
Decarbonizing the building stock is critical for realizing the climate-neutral target for the Netherlands.
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The LeiCNS-PK3.0 model development and applications: healthy-to-diseased CNS pharmacokinetic translation
Accurate prediction of the unbound drug concentration-time profile at the CNS target site is crucial for the assessment of the right drug concentration-effect relationship. PBPK models have supported the PK prediction of the CNS target sites and the translation of PK data between species and between…
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in special populations: towards semi-physiological pharmacokinetic models
M. Danhof, Co-promotores: J. Freijer, A. Yassen
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and tissue dynamics with cell fate decisions through computational modeling
There is a need for alternative methods to replace, reduce and refine (3R) animal experimentation. Combining experimental data from high-throughput in vitro studies with in silico modeling is a promising approach to unravel the effect of chemicals on living cells and to gain a better understanding of…