In this thesis, we have studied the potential of the zebrafish larval model in studying the ECS, as a complementary model to the existing rodent models.

Promotor: Prof.dr. S.F. Portegies Zwart

Thermodynamics is one of the founding scientific pillars that has helped us better understand heat engines, biology, ecosystems, and even black holes. While it fundamentally describes large systems by examining the bulk behavior of their constituents, it is anchored in the statistical equivalence of…

All crested and marbled newts (the genus Triturus) suffer from an unusual genetic abnormality, called a balanced lethal system, that kills exactly half of their offspring. How can a trait so disadvantageous have survived millions of years of natural selection?

Cardiovascular diseases are among the most frequent causes of death in the world. The main underlying pathology of cardiovascular diseases is the development of atherosclerosis in the medium and large-sized arteries.

Promotor: Prof.dr. M. Danhof

This dissertation is part of a broader research project that revolves around unraveling the evolution of balanced lethal systems.

Promotor: Prof.dr. J. Kuiper

Unfolding potential

The thesis addresses the long-term dynamical evolution of hierarchical multiple systems.

In the thesis the dynamics of strategies is studied from two perspectives.In the first part of the thesis strategies are considered to be opinions present in a community.

Promotor: W.Th.F. den Hollander

Promotor: Prof.dr. L.J. Slikkerveer

This thesis consists of two main parts. The first part (Chapters 2 and 3) deals with a class of Markov process called Quasi-Skipfree (QSF) processes.

Veel kinderen leren niet op een niveau dat aansluit bij hun potentieel om te leren. Diagnostiek in de leerlingbeleiding zou daarom inzicht moeten geven in hoe een kind begeleid kan worden in het verder ontwikkelen van zijn of haar sterke kanten terwijl het tegelijkertijd handvatten biedt voor het ondersteunen…

BlaC is the β-lactamase of Mycobacterium tuberculosis. We show that it can recover from inhibition by clavulanic acid and that phosphate helps it do so.

This thesis introduces the concept of

The solar system was formed approximately 4.56 billion years ago. Despite the numerous theories that have been developed over the years, the formation and evolution of the solar system still remain unclear.

Dynamical systems describe the evolution of objects in a space over time and may be used to model physical phenomena. Due to this, much research is dedicated to understanding the mathematics of dynamical systems.

Phospholipase A/acyltransferase 3 (PLAAT3) and PLAAT4 are enzymes involved in the synthesis of bioactive lipids. Despite sequential and structural similarities, the two enzymes differ in activity and specificity.

Promotor: Promotor: W.Th.F. den Hollander, Co-promotor: V. Sidoravicius.

Heterogeneous catalysis is one of the fundamental processes of modern life, being common in industrial refinery and hydrogen vehicles, all the way to the living cell. The dissociation of H2 on Cu(111) is an important benchmark system for studying heterogeneous catalysis, with a large and varied amount…

This thesis investigates opinion dynamics on random graphs through the lens of the voter model, a classical interacting particle system used to describe how consensus emerges in networks.

Promotor: J.W. van Holten

This study has been carried out in the community of Sukamiskin, a kelurahan (‘village’) in Bandung, the Capital of West Java Province, located in the Sunda Region of Indonesia.

Promotor: Prof.dr. H.J.M. de Groot, Co-promotor: Francesco Buda

Promotor: C. W. J. Beenakker, Co-promotor: J. K. Asboth

Promotor: H.J. van den Herik, B.R. Katzy, Co-promotor: K. Sailer

Promotor: W.Th.F. den Hollander, Co-promotor: F.R. Nardi

In this thesis, a system pharmacology approach, integrating metabolomics, pharmacology and chemical biology, was applied to understand and modulate the endocannabinoid system across different model systems (cells, zebrafish, mice and humans).

Promotor: S.M. Verduyn Lunel, Co-promotor: O. van Gaans

In this thesis, time-lapse fluorescent microscopy plays a pivotal role in investigating functional materials within living cells as well as the migratory behaviour of neural progenitor cells.

Promotores: Prof.dr. M. Danhof, Prof.dr. D.R. Stanski

Systems are called real-time systems, if the correctness of the system does not only depend on the correctness of the system output but also on whether the output is delivered on time.

For optimization problems, it is often unclear how to choose the most appropriate optimization algorithm. As such, rigorous benchmarking practices are critical to ensure we can gain as much insight into the strengths and weaknesses of these types of algorithms.

Het artikel 'Flexible updating of dynamic knowledge structures' met bijdrage van Franziska Richter van Cognitieve Psychologie is uitgebracht door Nature.

Epithelial-mesenchymal plasticity (EMP) and tumor cell migration play an important role in cancer progression, and an improved understanding of the mechanisms underlying these concepts is essential for developing new targeted approaches.

Het doel van het onderzoeksprogramma Systems Pharmacology ligt in de ontwikkeling van strategieën voor gepersonaliseerde geneesmiddelen en de ontwikkeling van nieuwe systeemgebaseerde benaderingen in de translationele en klinische farmacologie.

Adenosine is an endogenous ligand which exerts its action by activating adenosine receptors (ARs), while its circulating levels are controlled via a variety of mechanism and proteins, amongst others the equilibrative nucleoside transporters (ENTs).

Promotor: Prof.dr. G.J. Kroes

When a star gets too close to a supermassive black hole, it is torn apart by strong tidal forces in a tidal disruption event (TDE).

In the early universe, the dynamics of the Higgs field can give rise to many interesting phenomena.

According to the amyloid cascade hypothesis, accumulation of beta-amyloid (Aβ) peptides initiates the pathological cascade in Alzheimer's disease (AD).

Promotor: A. Doelman, Co-promotores: P.J.A. van Heijster; A. Zagaris

Drug development critically depends on preclinical models that mimic human physiology, yet traditional two-dimensional cultures and animal models often lack predictive power.