1,548 zoekresultaten voor “health and vascular disease” in de Publieke website
-
Innate immune modulation in atherosclerosis and vascular
Promotores: Prof.dr. J. Kuiper, Prof.dr. P.H.A. Quax, Co-promotor: I. Bot
-
biology of glucosylceramide metabolism fundamental studies and applications for Gaucher disease
This thesis describes biochemical investigations of glucocerebrosidase (GBA), the lysosomal β- glucosidase that is deficient in Gaucher disease (GD).
-
Zebrafish as vertebrate model of Gaucher disease
Lysosomal storage disorders (LSDs) are a group of orphan diseases characterized by lysosomal dysfunction or impaired lysosomal catabolism and affect collectively about 1 in 5000 live births.
-
Stress-induced modulation of the innate immune system in cardiovascular disease
Promotor: Prof.dr. J. Kuiper
-
Understanding disease suppressive soils
Soil is a home for an unbelievable diversity and abundance of microbial life that is essential for supporting life on our planet.
-
Health Governance
Groeiende gezondheidsverschillen, toenemende zorgkosten, de vergrijzing en het tekort aan zorgpersoneel zijn slechts enkele voorbeelden van uitdagingen waar de gezondheidszorg voor staat, zowel in Nederland als daarbuiten. Deze vraagstukken overstijgen de grenzen van de medische sector en raken aan…
-
Monitoring Alzheimer's disease in transgenic mice with ultra high field magnetic resonance imaging
Promotor: Prof.dr. H.J.M de Groot, Co-Promotor: A. Alia
-
Pesticides and health – challenges and opportunities for exposure assessment
The aim is to develop methods to assess environmental and occupational exposure to (individual) pesticides, to be applied in epidemiological studies investigating pesticide exposure and human health. Furthermore, we aim to investigate the potential association between exposure to pesticides and Parkinson’s…
-
Systems diagnosis of chronic diseases, explored by metabolomics and ultra-weak photon emission
Promotor: J. van der Greef; Co-promotor: E. van Wijk, M. Wang
-
Transcultural Health Care Utilisation in Serengeti of Tanzania: Towards Applied Ethnoscience in Public Health Management
The research provides insight into disease behavior in both rural and semi-urban areas in Serengeti in Tanzania.
-
Lipidomics study in liver metabolic diseases
The ideas underlying this thesis are that lipidomics may improve the diagnosis of liver metabolic diseases, and can provide further insights into the underlying pathophysiology of these diseases.
-
Development of an in vitro vascular network using zebrafish embryonic cells
One of the major limitations in culturing complex tissues or organs is the lack of vascularization in the cultured tissue. Development of a functional capillary bed could overcome this problem.
-
Circulating cells as biomarkers in cardiovascular disease : the difference between men and women
Promotor: J. Kuiper
-
Environmental and health impact of informal e-waste recycling
The majority (80%) of e-waste generated globally are recycled informally in developing countries.
-
Investigations on the role of impaired lysosomes of macrophages in disease
The research described in this thesis combines the latest insights in lysosomal function with lysosome centred cell signalling.
-
metabolomics for a systems biology approach to understand Parkinson's disease
Neurodegenerative diseases, including Parkinson’s disease (PD), are increasing in prevalence due to the aging population. Despite extensive study, these diseases are still not fully understood and the lack of personalised treatment options that can target the cause of the diseases, rather than the symptoms,…
-
Preclinical validation of putative targets in cardiovascular and metabolic disease
Cardiovascular disease is the number one cause of death worldwide. The most important risk factor for developing this disease is high cholesterol levels in the blood.
-
Computational Approaches to Disease, Signaling and Drug Targets
The Minor Computational Approaches to Disease, Signaling and Drug Targets (CADSDT) is focused on fundamental scientific research required for discovery of new drug targets and development of new drugs.
-
Single cell mechanics for disease biology and pharmacology
In this thesis, we describe the potential of cell mechanical phenotyping for immune cell characterization, diagnosis, drug testing, as well as treatment of disease.
-
Systems diagnosis in chronic disease: prediction and evaluation
Promotor: J. van der Greef, T. Hankemeier; Co-promotor: H.A. van Wietmarschen
-
multisource data-based dynamic modeling to cell-cell signaling and infectious disease spreading
The emergence of complex diseases resulting from abnormal cell-cell signaling and the spread of infectious diseases caused by pathogens are significant threats to humanity. Unraveling the dynamic mechanisms underlying cell-cell signaling and infectious disease spreading is crucial for effective disease…
-
angiogenesis - Reverse engineering the role of tip cells and pericytes in vascular development
Promotor: Prof.dr. R.M.H. Merks
-
Studies on the Pathogenesis of Chronic Kidney Disease
In this thesis, two potential therapeutic targets for diabetic nephropathy were dentified and investigated. First, we show that glomerular clusterin is upregulated in diabetic nephropathy and demonstrated that recombinant clusterin protein can protect the podocytes against oxidative stress in vitro.…
-
Lipids as therapeutic targets for barrier repair in skin diseases
The skin is our natural barrier and lipids are a key part of this barrier. In the outer skin layer, the stratum corneum (SC), lipids form a densely organized structure dependent on the composition of these lipids.
-
Developing systems for high-throughput screening of infectious diseases using zebrafish
Promotor: Prof.dr. H.P. Spaink, Co-promotor: Prof.dr. A.H. Meijer
-
Post-Interventional Vascular Remodeling; Novel Insights and Therapeutic Strategies
Promotie
-
Structural Health Monitoring Meets Data Mining
Promotor: Prof.dr. J.N. Kok, Co-promotor: A.J. Knobbe
- Occupational Health Psychology (MSc)
-
Population Health Governance
Het Leiden Leadership Centre werkt samen met de onderzoeksgroep Population Health Governance (LUMC-Campus Den Haag) op onderwerpen die raken aan governance en leiderschap in de zorg. Deze onderzoeksgroep is onderdeel van het stimuleringsgebied Population Health van de Universiteit Leiden. Onder de eerste…
-
Population Health Management (MSc)
De hedendaagse gezondheidszorg staat voor vele uitdagingen. De nieuwe interdisciplinaire master PHM leidt je in twee jaar op om een bijdrage te kunnen leveren aan een meer geïntegreerd gezondheidszorgsysteem.
-
Lokal: indigenous medical knowledge and practice for integrated nursing of the elderly with cardiovascular disease in Sumedang, West Java: towards
The different kinds of cultural perspectives on health and disease of the participants are related to their knowledge, beliefs, values and practices manifested in various forms of lifestyle in Indonesia. The cultural diversity of the population is also related to differences in health behaviour.
-
Non-invasive biomarkers for inflammatory skin diseases: towards systems dermatology
Inflammatory skin diseases such as psoriasis and atopic dermatitis can severely impact both the physical and social aspect of a patient’s life. Aberrant inflammatory responses are thought to be a major causative factor in these disorders, but an abundance of different factors contribute to the development…
-
Student-for-a-Day Population Health Management
Studievoorlichting
-
Student-for-a-Day Population Health Management
Studievoorlichting
-
PhD Candidate in Immuno-biology and Infectious disease
Wiskunde en Natuurwetenschappen
- Health and Medical Psychology (MSc)
-
functional brain connectivity: pharmacological modulation, aging and Alzheimer's disease
Psycholoog Bernadet Klaassens heeft een groot fMRI-onderzoek opgezet naar het effect van medicijnen op hersennetwerken bij veroudering en de ziekte van Alzheimer. Het leverde een unieke dataset op en zicht op een nieuwe methode om medicijnen te ontwikkelen voor patiënten met Alzheimer.
-
Health, Ageing and Society (MSc)
De masteropleiding Health, Ageing and Society bereid studenten voor op een betekenisvolle rol in het verbeteren van de kwaliteit van leven van ouderen, en de kwaliteit en organisatie van de zorg voor een verouderende samenleving. Onze studenten voelen zich sterk betrokken bij maatschappelijke vraagstukken…
-
Development of personalized health monitoring using ultra-weak photon emission based on systems medicine concepts
Promotor: Jan van der Greef; Co-promotors: Mei Wang; Eduard van Wijk
-
Deeltijd masteropleiding Health, Ageing & Society
Studievoorlichting
-
stable-isotope labeling: exploring neuronal metabolism related to Parkinson’s disease
The progressive loss and degeneration of dopaminergic neurons is a major pathological hallmark of Parkinson's disease (PD). The onset and progression of PD can be triggered by multiple risk factors, for instance, genetic mutation, environmental exposure, and aging.
-
Macrophage activation and cholesterol in atherosclerosis development
Current therapies for patients with atherosclerosis are targeted primarily on reducing blood cholesterol, but this fails to prevent a large number of cardiovascular events.95 In order to identify new therapeutic strategies for treating atherosclerosis, it is important to study the interactions between…
- Clinical and Health Psychology (research) (MSc)
-
Iber Kasehatan in Sukamiskin: Utilisation of the Plural Health Information and Communication System in the Sunda Region of West Java, Indonesia
This study has been carried out in the community of Sukamiskin, a kelurahan (‘village’) in Bandung, the Capital of West Java Province, located in the Sunda Region of Indonesia.
-
Essays on wealth, health, and data collection
Op 21 november 2018 verdedigde Lieke Kools haar proefschrift 'Essays on wealth, health, and data collection'. Het promotieonderzoek is begeleid door promotoren prof. dr. K.P. Goudswaard en prof. dr. C.L.J. Caminada.
-
Comparative biology of common and grey seals along the Dutch coast : stranding, disease, rehabilitation and conservation
Promotores: H.A. Udo De Haes, P.M. Brakefield
- Health and well-being in a healthy society
-
from nature: using plant-soil feedback principles to improve growth and health of a horticultural crop
Plants and soils from natural ecosystems harbor great diversity of soil microorganisms, which could potentially contribute to the sustainability of horticulture. The knowledge about using wild plant species and soil from natural ecosystem to improve the crop health will advance the application of ecological…
-
Public Health and the American State
Dit boek onderzoekt hoe zorgen over de volksgezondheid en politieke agenda’s elkaar in de VS de afgelopen eeuw hebben beïnvloed.
-
Cardiovascular health disparities
Promotie