489 zoekresultaten voor “tell immune response” in de Publieke website
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Glucocorticoid modulation of the immune response
Glucocorticoids (GCs) are widely prescribed as anti-inflammatory drugs due to their well-established immunosuppressive effects.
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Mast cells as immune regulators in atherosclerosis
Cardiovascular syndromes are the major cause of death in Western societies.
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The innate immune response against mycobacterial infection: analysis by a combination of light and electron microscopy
Promotores: Prof.dr. H.P. Spaink & Prof.dr. P.C.W. Hogendoorn Co-promotor: Dr. M.J.M. Schaaf
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Innate immune modulation in atherosclerosis and vascular
Promotores: Prof.dr. J. Kuiper, Prof.dr. P.H.A. Quax, Co-promotor: I. Bot
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Synthetic carbohydrate ligands for immune receptors
One of the main challenges in the development of an effective anti-cancer vaccine is the generation of an adequate and directed cellular immune response.
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Key innate immune components controlling intracellular infection
Promotor: H.P. Spaink, Co-Promotor: A.H. Meijer
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Liposome-based vaccines for immune modulation: from antigen selection to nanoparticle design
Nanoparticles can be used as delivery systems for both small molecules and macromolecules such as proteins, peptides or oligonucleotides. This thesis focuses on the use of liposomes, nanometric vesicles formed by a lipid bilayer enclosing an aqueous core. Liposomes are highly versatile delivery syst…
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Novel Immune Cell-Based Therapies for Atherosclerosis
Promotor: Prof.dr. J. Kuiper
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Stress-induced modulation of the innate immune system in cardiovascular disease
Promotor: Prof.dr. J. Kuiper
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Modulation of the immune system for treatment of atherosclerosis
Cardiovascular diseases are the primary cause of death in the world with atherosclerosis as primary underlying cause.
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The interplay between lipids and the immune system in atherosclerosis
Cardiovascular diseases are among the most frequent causes of death in the world. The main underlying pathology of cardiovascular diseases is the development of atherosclerosis in the medium and large-sized arteries.
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Insights from modeling metabolism and amoeboid cell motility in the immune system
This thesis focuses on two processes involved in fighting infections: metabolism and immune cell motility and navigation.
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Click-to-release for immune cell activation
This work describes the use of click-to-release chemistry to get spatiotemporal control over immunocytokine activity. Until now, immunocytokines (cytokines coupled to a tumor-targeting-moiety) remained active throughout the body, being able to bind their respective receptors, causing mild to severe…
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Toll-like receptor signaling in the innate immune system of zebrafish larvae
Promotor: H.P. Spaink, A.H. Meijer Co-promotor: R. Marin-Juez
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Unfolding the regulation of stress response pathways upon liver injury
Drug-induced liver injury (DILI) is one of the main reasons for drug attrition during pre-clinical and clinical phases of drug development as well as for drug withdrawal post-marketing.
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Computational modeling of mycobacterium infection and innate immune reponse in zebrafish
Promotor: Prof.dr. J.N. Kok
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Swimming Bass under Pounding Bass: fish response to sound exposure
Promotor: C.J. ten Cate, Co-promotor: H.W. Slabbekoorn
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Synthesis of chemical tools to study the immune system
This thesis describes the synthesis and biological evaluation of TLR2/6, TLR4, TLR7/8 and TLR9 ligands, of which the activity can be conditionally controlled.
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Boosting the host immune system to fight tuberculosis
New drugs for use as tuberculosis (TB) treatment are needed due to the constrains of classical antibiotics against TB and the rise of antibiotic-resistant strains, making TB a harder and harder disease to treat.
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Design and Synthesis of Click Lipids as Tools to Study Immune Cell Metabolism
This thesis advances our understanding of lipid uptake, a vital first step in lipid metabolism, by developing innovative click chemistry-based tools to study how immune cells internalize lipids.
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Systems microscopy to unravel cellular stress response signalling in drug induced liver injury
Promotor: B. van de Water
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Mast cell-mediated immune modulation in experimental Rheumatoid Arthritis and Atherosclerosis
In this research project, we aimed to obtain more insight in the role of mast cells in the immune driven disorders rheumatoid arthritis and atherosclerosis.
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Single-cell immune profiling of atherosclerosis: from omics to therapeutics
Acute cardiovascular syndromes, including myocardial infarction or stroke, are the principal cause of death in the Western society. The main underlying pathology of cardiovascular diseases is atherosclerosis, which is caused by the accumulation of lipids and inflammatory cells in the vessel wall, in…
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Invertebrate response to management of roadside edges
Does roadside management in the mid-west USA increase invertebrate diversity similar to practices in Europe?
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Mechanical Response of Foams: Elasticity, Plasticity, and Rearrangements
Promotor: M.L. van Hecke
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exploration of modular goldnanoparticles for glycan-based immune-interventions of worm infections
Chiodo
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What does the evidence tell us about merit principles and government performance?
Ambtenarensystemen zijn wereldwijd krijgen wereldwijd veel kritiek. Dit artikel presenteert een onderzoek naar bewijsmateriaal over over overheidsprestaties en merictocratie.
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Adaptive responses to environmental changes in Lake Victoria cichlids
Promotor: M.K. Richardson, Co-Promotor: F. Witte
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Children's Response to Humor in Translated Poetry
Op12 promoveert Alice Ross T. Morta. Het Leiden University Centre for Linguistics feliciteert Alice!
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The Bulgarian governments' response to Covid-19
Bulgarije kwam relatief ongeschonden uit de eerste golf, maar in het najaar van 2020 namen het aantal infecties, ziekenhuisopnames en sterfgevallen sterk toe. Dit onderzoek analyseert hoe de Bulgaarse regering op de Covid-19 pandemie heeft gereageerd.
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Rosema & Louwerse, ‘Response scales in Voting Advice Applications’
Stemwijzers—applicaties die kiezers helpen te bepalen welke partij of kandidaat het beste past bij hun politieke voorkeur—spelen een steeds belangrijker rol in verkiezingen. De politicologen Martin Rosema (Universeit Twente) en Tom Louwerse (Universiteit Leiden) onderzoeken of het ontwerp van deze publicaties…
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Quantitative modelling of the response of earthworms to metals
Promotor: Prof.dr. W.J.G.M. Peijnenburg
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never happen: Genaralized unsafety and prolonged psysiological stress responses
The aims of the project are to: further clarify 'inhibition by safety'; explore and describe all possible sagety factors, with a special focus on the primary human safety source: social connectedness; reviewing prolonged stress responses without stressors.
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Hearing what singing fish tell us about healthy oceans
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Dynamics and regulation of the oxidative stress response upon chemical exposure
The focus of the described research in this thesis is on the oxidative stress response (Nrf2 pathway). The aim of the research presented in this thesis is to obtain more information concerning microRNAs which are involved in the Nrf2 pathway, to determine and evaluate the application of microRNAs for…
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European-wide ecosystem responses and their vulnerability to intensive drought
There is accumulating evidence for an increase in severe global drought events. In particular, Europe experienced several severe droughts in 2003, 2015, and 2018 (unprecedented in the past 2,110 years). Such droughts have caused serious and far-reaching impacts on terrestrial ecosystems.
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The early stress response of jasmonic acid in cell suspension cultures of Catharanthus roseus
In order to gain a better insight into the basis of the rapid jasmonic acid (JA)-mediated stress response, an integrated approach using a targeted high-resolution mass spectrometry-based (HRMS) platform, was conducted to monitor the metabolism of JA using the model system of cell suspension cultures…
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Intradermal delivery of nanoparticulate vaccines using coated and hollow microneedles
In summary, the collective results described in this thesis show that nanoparticulate vaccines can be delivered intradermally by coated and hollow microneedles and evoke antigen-specific immune responses.
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The role of AGC3 kinases and calmodulins in plant growth responses to abiotic signals
Promotor: Prof.dr. P. Hooykaas, Co-promotor: R. Offringa
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Climate Change Response in Weak Rule-of-Law Environments
Deze sociaal-juridische studie richt zich op de implementatie van wetgeving en beleid op het gebied van klimaatverandering in ontwikkelingslanden met een zwakke rechtsstaat en de (onvoorziene) effecten daarvan op de landrechten van kwetsbare bevolkingsgroepen.
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Innate immunity, developmental speed and their trade-offs in two hexapod models
This thesis focuses on important life history traits and their trade-offs using two hexapod models. Particularly, the trade-off between immune defense and embryonic developmental speed is a central theme of this study.
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Metabolic signatures in nutrition and health: short-term diet response, sexual dimorphism and hormone chronobiology
The power of personalized nutrition lies in being able to conduct clinical research on healthy people while capturing metabolic markers sensitive to the impact of environmental and metabolic stressors (e.g. diet, changing sex hormones and the menstrual cycle).
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Gisela Hirschmann, Coronavirus: A Global Crisis Waiting for a Global Response
Vaak wordt gezegd dat een crisis iemands ware aard naar boven brengt. Het coronavirus stelt het multilaterale systeem op de proef. Politicoloog Gisela Hirschmann (Universiteit Leiden) maakt zich zorgen over de toekomst van internationale samenwerking.
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Boys Deflect Responsibility for Street Harassment: Class, Race, and Responses to Sexual Violence Awareness Programs
Onderzoek toont aan hoe jongens reageren op bewustwordingstrainingen over intimidatie en waarom ze straatintimidatie vaak niet als 'hun' probleem zien.
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Securing Humanitarian Operations: Preparedness and Response to Cyber Crises in Aid Delivery
Hoe hebben humanitaire organisaties voorbereidings- en responsstrategieën voor cyberincidenten afgestemd op hun specifieke prioriteiten, behoeften en context?
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Multilevel governance and responses to the COVID-19 pandemic: a systematic literature review
Dit artikel geeft een overzicht van de literatuur over de effecten van multilevel governance (MLG) op de beleidsreacties van regeringen op Covid-19.
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Adolescents' responses to online peer conflict: How self‐evaluation and ethnicity matter
Tijdens het spelen van online games kunnen conflicten ontstaan. Novin, Bos, Stevenson en Rieffe onderzochten in dit artikel welke factoren maken dat de ene jongere daarbij bozer reageert dan de andere. In hun realistisch nagemaakte spel begon de zogenaamde medespeler plotseling te mopperen dat de deelnemer…
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Resistance to PARP inhibition by DNA damage response alterations in BRCA1/2-deficient tumors
Inactivating mutations in BRCA1 or BRCA2 genes predispose to several types of cancer.
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Fungi of the greening Arctic: compositional and functional shifts in response to climatic changes
Promotor: E.F. Smets Co-promotor: J. Geml
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‘Tell them if they race-mix, they will rot in hell’: right-wing extremists’ narratives on children’s ideological socialisation
In dit artikel onderzoeken Layla van Wieringen, Daan Weggemans en Marieke Liem hoe rechts-extremistische ouders de ideologische socialisatie van hun kinderen bespreken en rechtvaardigen.