In this thesis an activity-based probe was discovered that could visualize the activity of PLAATs. With an optimized gel-based ABPP assay in hand, screening of a compound library led to the discovery of alpha-ketoamides as a hit for PLAAT3.

The spindle-assembly checkpoint (SAC) is a safety mechanism which secures accurate chromosome segregation during mitosis.

Monoacylglycerol lipase (MAGL) is the principal enzyme responsible for hydrolysis of the endocannabinoid 2-arachidonoylglycerol (2-AG). MAGL inhibition provides several potential therapeutic opportunities, including anti-nociceptive, anti-inflammatory and anti-cancer activity.

Diacylglycerol lipases (DAGLα and DAGLβ) are responsible for the biosynthesis of the endocannabinoid 2-arachidonoylglycerol (2-AG) in the brain and peripheral tissues. Selective DAGLβ inhibitors have been proposed as a potential treatment for inflammatory diseases with reduced potential for central…

The disease acute myeloid leukemia (AML) is characterized by fast progression and low survival rates.

Promotor: G.P. van Wezel, Co-promotor: Y.H. Choi

Global healthcare is on the verge of an antibiotic availability crisis as bacteria have evolved resistance to nearly all known antibacterials. Identifying new antibiotics that operate via novel modes-of-action is therefore of high priority.

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

In the last decades, activity-based protein profiling (ABPP) has emerged as a powerful chemical tool that may aid the ever-challenging drug discovery process.

The investigations described in this thesis lay out strategies aimed at advancing antibiotic research and development. The examples presented revolve around two main approaches: understanding drug-target interactions and target identification.

How are new drugs developed? This question is central to the Minor Modern Drug Discovery (MDD), which covers the entire trajectory from disease to drug molecule and vice versa. The various research groups involved offer a complementary and interdisciplinary perspective by connecting the diverse subjects…

Pectin is a plant cell wall polysaccharide made of mainly D-galacturonic acid (GA) subunits. The potency of the filamentous fungus Aspergillus niger to naturally secrete high amounts of pectinases to degrade pectin has been utilized for the industrial production of pectinases.

The adenosine receptors are proteins that reside in the extracellular membranes of cells. Activation of adenosine receptors plays a role in many physiological and pathological processes, such as immune responses and cancers.

Promotor: Prof.dr. T. Hankemeier, Prof.dr. J.C.T. Eijkel (Twente University)

Drug-target binding kinetics determine the time course of the central event in pharmacotherapy: Drug-target interaction.

Promotor: A.P. IJzerman

The energy system is at the heart of two of the greatest challenges of the 21st century: decreasing CO2 emissions to meet the ambitions of the Paris agreement while fulfilling the growing energy demand associated with the economic aspirations of a growing world population.

In het onderzoeksprogramma Drug Discovery & Safety zijn we geïnteresseerd in de werkzaamheid en veiligheid van nieuwe medicijnen en nieuwe manieren om deze aspecten te bepalen. Daarvoor combineren we geavanceerde imaging en high-throughput screening technieken met computationele aanpakken zoals chem-…

The main aim of this project is to reveal and unravel the invisible histories of the UN, transcending the dominant Western perspective to recover the historical agency of Global South actors. The research will investigate how the UN has both facilitated and limited their role in shaping global order…

This thesis presents pioneering work on the panchromatic emission of some of the most luminous galaxies in the early Universe: star forming galaxies and active galactic nuclei.

Dit boek onderzoekt de impact van het VN-Verdrag inzake de Rechten van het Kind (IVRK) op nationale en internationale rechtspraak, sinds de aanname van dit verdrag in 1989. Het boek verschaft inzicht in de functies, uitdagingen en beperkingen van het IVRK in nationale, regionale en internationale juridische…

This thesis focuses on data found in the field of computational drug discovery. New insight can be obtained by applying machine learning in various ways and in a variety of domains. Two studies delved into the application of proteochemometrics (PCM), a machine learning technique that can be used to…

The thesis is about the study of shell evolution of the Hydrocenidae of the genus Georissa. This thesis started with a general overview on the evolutionary process of animals due to ecological changes.

Promotor: W. Jaffe, Co-promotor: K. Meisenheimer

This dissertation investigates the energy and material related impacts of the transition towards a low-carbon heating system in the Netherlands, in the context of its 2050 climate and circular economy policy goals.

Promotor: Johan Kuiper, Co-promotor: Saskia C.A. de Jager

Heart failure is a major health care problem with high mortality.

The expedition commanded by Nicolas Baudin to Tenerife, Mauritius, Australia, Timor and South Africa in 1800-1804 is fully researched in regard to ornithology.

The haplolepideous mosses (Dicranidae) comprise about 4000 species distributed over a wide range of habitats, with great gametophytic and sporophytic morphological variation. Their monophyly is well supported by the results of several molecular phylogenetic studies, which shed light on their relationships…

Promotor: P. T. de Zeeuw, Co-promotor: N. Neumayer; G. van de Ven

According to the amyloid cascade hypothesis, accumulation of beta-amyloid (Aβ) peptides initiates the pathological cascade in Alzheimer's disease (AD).

Glucocorticoids (GCs) are widely prescribed as anti-inflammatory drugs due to their well-established immunosuppressive effects.

Supervisor: S.F. Portegies Zwart Co-Supervisor: A.G.A. Brown

Op 11 mei 2016 ontving het Hazelhoff Centre for Financial Law Robert Pickel voor de elfde Hazelhoff Guest Lecture, getiteld ‘The Deadliest Sin of the Financial Crisis’.

In this thesis, a system pharmacology approach, integrating metabolomics, pharmacology and chemical biology, was applied to understand and modulate the endocannabinoid system across different model systems (cells, zebrafish, mice and humans).

High-angular-resolution observations of the circumstellar material have uncovered numerous and very diverse substructures in protoplanetary discs, raising the question of whether they are caused by forming planets or other mechanisms.

Promotor: S.J. Edixhoven, L.D.J. Taelman

Hoe zetten belangenorganisaties in Nederland strategisch procederen in om politieke, maatschappelijke of juridische veranderingen te realiseren, en hoe verhoudt deze strategie zich tot andere klassieke vormen van beleidsbeïnvloeding?

Explore "Surgical anatomy of the leg in relation to nerve injuries" at Boerhaave Nascholing. Read more here.

Promotor: T. Hankemeier, Co-promotor: R.J. Vreeken

Promotores: Prof.dr. G.A. Persoon & Prof. dr. H.H. de Iongh

Trigonostemon Blume is a plant genus in the family Euphorbiaceae comprising 59 species.