283 zoekresultaten voor “immuniteit infection en tolerance” in de Publieke website
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Immuniteit, Infectie en Tolerantie
Het immuunsysteem beschermt ons tegen ziekten, maar soms gaat het mis. Dan dringt er toch een vijand binnen of valt het immuunsysteem ons eigen lichaam aan, waardoor we ziek worden. Artsen en onderzoekers van het Leids Universitair Medisch Centrum (LUMC) willen het immuunsysteem zodanig sturen, dat…
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Solvent tolerance mechanisms in Pseudomonas putida
Bacterial biocatalysis constitutes a sustainable alternative for high-value chemicals production by enabling the utilization of renewable feedstocks.
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Key innate immune components controlling intracellular infection
Promotor: H.P. Spaink, Co-Promotor: A.H. Meijer
- Ecology, Migration and Tolerance: Limits to Cooperation
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Computational modeling of mycobacterium infection and innate immune reponse in zebrafish
Promotor: Prof.dr. J.N. Kok
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Selective autophagy in host defense against mycobacterial infection
The effective treatment of tuberculosis (TB) remains a major challenge to global health.
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extraembryonic serosa protects the insect egg against desiccation and infection
Promotor: Prof.dr. H.P. Spaink, Co-promotor: Dr. M. van der Zee
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Regulation of autophagy-related mechanisms during bacterial infection
Autophagy is a fundamental degradative process, maintaining cellular homeostasis and functions in host defense against intracellular pathogens, including mycobacteria and Salmonella.
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Oratie: Aangeboren immuniteit in beeld
Tuberculosebacteriën en andere intracellulaire pathogenen gebruiken immuuncellen als paard van Troje om zich in hun gastheer te verspreiden. Annemarie Meijer, hoogleraar immunobiologie, vertelt hoe onderzoek naar mechanismen van aangeboren immuniteit in zebravissen helpt om nieuwe behandelingsmethoden…
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The rhizomicrobiome of Sorghum ; impact on plant growth and stress tolerance
The overall objectives of my thesis are to investigate the dynamics of the sorghum root microbiome and to explore the beneficial effects of the root microbiome on sorghum growth and stress tolerance.
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The innate immune response against mycobacterial infection: analysis by a combination of light and electron microscopy
Promotores: Prof.dr. H.P. Spaink & Prof.dr. P.C.W. Hogendoorn Co-promotor: Dr. M.J.M. Schaaf
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The Function of Toll-like receptor 2 in Infection and Inflammation
The function of TLRs in innate immunity has aroused worldwide attention soon after its discovery. Because of the broad functions of TLR2 in innate immunity, the drive for the development of TLR2-targeted vaccines or therapeutic treatments has accelerated in the last decades.
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Chemokine signaling mechanisms underlying inflammation and infection control: insights from the zebrafish model
This thesis focuses on the role of chemokine receptors CXCR3 and CCR2 in the inflammatory process and infection control using the zebrafish model.
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Dissecting the role of the airway epithelium in mycobacterial infections
Promotie
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Diagnosis, prevention, and treatment of acute respiratory viral infections
Promotie
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Cornelis HokkeFaculteit Geneeskunde
c.h.hokke@lumc.nl | +31 71 526 5065
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Bart RoepFaculteit Geneeskunde
b.o.roep@lumc.nl | +31 71 526 3869
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Liposome-based vaccines for immune modulation: from antigen selection to nanoparticle design
Nanoparticles can be used as delivery systems for both small molecules and macromolecules such as proteins, peptides or oligonucleotides. This thesis focuses on the use of liposomes, nanometric vesicles formed by a lipid bilayer enclosing an aqueous core. Liposomes are highly versatile delivery syst…
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An uncertain recovery: The physical toll of COVID-19 infection on liberal arts and sciences students in the Netherlands
Josien de Klerk en Tennessee Miller onderzochten de interactie tussen de ziekte- en herstelervaringen van studenten en de academische werkcultuur in deze context.
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Johan de FijterFaculteit Geneeskunde
j.w.de_fijter@lumc.nl |
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Virus-host metabolic interactions: using metabolomics to probe oxidative stress, inflammation and systemic immunity
Promotores: T. Hankemeier; R. Berger, Co-promotor: R.J. Vreeken
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Studies on molecular basics of metabolic syndrome in zebrafish
The research described in this thesis has, using the zebrafish as a model system, shed new light on the intricate relationship between TB and DM2, in particular on the role of leptin, SHP-1 and glucocorticoids.
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Quantitative pharmacology of antimicrobials
Antimicrobial drugs constitute a fundamental part of modern medicine. The global rise in antimicrobial resistance poses a major threat to global health.
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Frank BaasFaculteit Geneeskunde
f.baas@lumc.nl |
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Het immuunsysteem versterken tegen antibioticaresistente tuberculose
Kunnen kleine moleculen het immuunsysteem herstellen en helpen tuberculose te bestrijden door autofagie te stimuleren?
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Phenotypic engineering of photosynthesis related traits in Arabidopsis thaliana using genome interrogation
Promotor: P.J.J. Hooykaas, Co-Promotor: E.J. van der Zaal
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Vaccination and Targeted Therapy Using Liposomes; Opportunities for Treatment of Atherosclerosis and Cancer
This thesis focuses on using liposomes in two different treatment strategies; vaccination (or immunotherapy) and delivery of a small molecule, and in two different disease models; cancer and atherosclerosis.
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Cornelis van KootenFaculteit Geneeskunde
c.van_kooten@lumc.nl | +31 71 526 2148
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2,3 miljoen euro voor onderzoek naar vaccin voor worminfectie schistosomiasis
Onderzoekers van het Leids Universitair Medisch Centrum (LUMC) hebben 2,3 miljoen euro ontvangen van het EU Horizon 2020-programma en de Wellcome Trust om met internationale partners te werken aan een vaccin voor infectie met de parasitaire worm Schistosoma.
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Glucocorticoid modulation of the immune response
Glucocorticoids (GCs) are widely prescribed as anti-inflammatory drugs due to their well-established immunosuppressive effects.
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We waren neutraal, maar niet immuun: Henk te Velde over de Eerste Wereldoorlog
Vrouwenkiesrecht, eenheidsworst en gloeilampen: drie ongebruikelijke gevolgen van de Eerste Wereldoorlog. Henk te Velde, historicus en houder van de leerstoel Vaderlandse Geschiedenis, sprak met Scientias.nl over hoe de Eerste Wereldoorlog het (dagelijkse) leven in Nederland beïnvloedde.
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Actualiteiten - Internationale Immuniteiten in de Nederlandse rechtspraktijk
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From stress to success; How actinobacteria exploit live without a cell wall
The aim of this thesis was to study phage infection in Streptomyces, focused on cell wall-deficient cells. Bacteriophages (or phages in short) attach to the cell wall of bacteria after which they replicate and lyse the host cell.
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Autophagy and Lc3-associated phagocytosis in host defense against Salmonella
Control of infectious diseases poses continuous challenges for human health.
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Modulation of the immune system for treatment of atherosclerosis
Cardiovascular diseases are the primary cause of death in the world with atherosclerosis as primary underlying cause.
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Jaap van DisselFaculteit Geneeskunde
j.t.van_dissel@lumc.nl | 071 5269111
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Systems vaccinology: molecular signatures of immunity to Bordetella pertussis
Promotor: G.F.A. Kersten, W. Jiskoot, Co-promotor: B. Metz
- Symposium: A Dutch Perspective on Mycobacterial Infections
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Global metabolomics and lipidomics approaches to probe virus-host interactions
The outbreaks of AIDS and COVID-19 showed clearly how infectious viruses can influence people’s lives. Investigating the changes in the host metabolism may provide a paradigm shift to consider immune-metabolic interactions as therapeutic targets.
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Exploitation of host chemokine signalling by pathogenic mycobacteria
Promotores: A.H. Meijer, H.P. Spaink
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Betere vaccins tegen malaria en tuberculose
De infectieziektes malaria en tuberculose zijn verantwoordelijk voor 2.1 miljoen dodelijke slachtoffers per jaar. Op dit moment testen Leidse onderzoekers een nieuw tuberculosevaccin.
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Human-wildlife Interactions in the Western Terai of Nepal
Large carnivores and humans, along with their livestock, have co-existed for thousands of years. However, human population growth and an increase in economic activities are modifying the landscape for large carnivores and their prey.
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Insights from modeling metabolism and amoeboid cell motility in the immune system
This thesis focuses on two processes involved in fighting infections: metabolism and immune cell motility and navigation.
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Groen licht voor het testen van een malariavaccin
Onderzoekers van het Leids Universitair Medisch Centrum (LUMC) en het Radboudumc hebben groen licht gekregen om vrijwilligers opzettelijk met malaria te besmetten, om een veelbelovend vaccin bij hen te testen.
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Anti-microbial and Anti-biofilm compounds From Indonesian Medicinal Plants
Promotor: C.A.M.J.J. van den Hondel, Co-promotor: Sandra de Weert
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Developing systems for high-throughput screening of infectious diseases using zebrafish
Promotor: Prof.dr. H.P. Spaink, Co-promotor: Prof.dr. A.H. Meijer
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Mark van BuchemFaculteit Geneeskunde
m.a.van_buchem@lumc.nl | +31 71 526 4376
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Leiden bundelt kracht om verbeterde vaccins voor coronavirussen te ontwikkelen
De publieke-private samenwerking tussen het Leids Universitair Medisch Centrum (LUMC) en twee Leidse bedrijven, ISA Therapeutics en Immunetune, heeft 724.000 euro ontvangen van Health~Holland (Topsector Life Sciences & Health). Het geld zal gebruikt worden om vaccins tegen het huidige coronavirus en…
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Eric SnijderFaculteit Geneeskunde
e.j.snijder@lumc.nl | +31 71 526 1657
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Jacco Wallinga
Faculteit Geneeskunde
j.wallinga@lumc.nl | +31 71 526 9111