This thesis was embedded in the APELAFICO project and focussed on investigating effects of sound from North Sea offshore wind farms on pelagic fish and harbour porpoise.

Surface acoustic waves (SAWs) are mechanical waves that travel along the surface of a material and find many applications in modern technologies due to the ease of excitation on piezoelectric substrates via interdigital transducers (IDTs).

This minor is focused on fundamental scientific research required for discovery of new drug targets and development of new drugs. Students learn how disease and drug-induced alterations in signaling pathways can be used for the discovery of new drug targets and the development of personalized drugs.

Synthesis and application of chemical biology tools to study immunomodulatory signaling lipids.

Promotor: H.P. Spaink, A.H. Meijer Co-promotor: R. Marin-Juez

Invasive lobular carcinoma (ILC) is the second most common type of breast cancer.

In previous studies at our laboratory it was demonstrated that drug exposure of HepG2 cells can lead to an altered TNFα-induced NF-κB oscillatory phenotype, concurrent with a synergistically increased sensitivity for TNFα-induced apoptosis.

Signalen zijn essentieel voor het leven. Signalen uitzenden en signalen ontvangen doen wij doorlopend. Jeroen den Hertog, hoogleraar Moleculaire ontwikkelingszoölogie, onderzoekt de overdracht van signalen op moleculair niveau.

Lipid signaling is an essential biological event/process in a plethora of pathophysiological conditions. The underlying idea of this thesis is that many of the roles and the complex interplay of the individual signaling lipids in inflammatory processes and related conditions in health and disease is…

Toll-like receptors (TLRs) are central components of the innate immune system, functioning as pattern recognition receptors that detect microbial- and damage-associated molecular patterns and initiate antimicrobial and inflammatory responses.

This thesis focuses on the role of chemokine receptors CXCR3 and CCR2 in the inflammatory process and infection control using the zebrafish model.

Promotores: C. J. ten Cate; M. A. Ainslie. Co-promotor: W. Slabbekoorn

The emergence of complex diseases resulting from abnormal cell-cell signaling and the spread of infectious diseases caused by pathogens are significant threats to humanity. Unraveling the dynamic mechanisms underlying cell-cell signaling and infectious disease spreading is crucial for effective disease…

This thesis considers multi-prover commitment schemes whose security is based on restrictions on the communication between the provers.

The PID-directed shift in PIN polarity has been broadly accepted as one of the essential mechanisms for the regulation of auxin transport polarity.

In een longitudinale studie onderzochten Adva Eichengreen en collega's hoe aspecten van emotionele intelligentie de ontwikkeling van de geestelijke gezondheid van adolescenten beïnvloeden. Zo identificeerden ze potentiële waarschuwingssignalen en doelen voor interventieprogramma's.

Promotor: Prof.dr. M.A.G.J. Orrit

Geometric phases lead to a nontrivial interference result when an electron's different quantum mechanical paths choices encircle a magnetic coil in an Aharonov-Bohm experiment.

'Het enige signaal van dit instituut dat we nog niet begrijpen.' Dat is het Wow!-signaal, precies 40 jaar geleden opgevangen uit de ruimte. Leids astronoom Ignas Snellen vertelt erover in een achtergrondartikel op Scientias.

Door massa’s gegevens van de Europese röntgensatelliet XMM-Newton door te worstelen, hebben wetenschappers van de Universiteit Leiden en de École polytechnique fédérale de Lausanne (Zwitserland) een signaal opgespoord dat afkomstig kan zijn van donkere materie.

Promotor: A.H. Meijer, Co-promotor: B.E. Snaar-Jagalska

De kans is groot dat de formerende partijen in Den Haag een streep zetten door het raadgevend referendum. D66 zou referenda, zoals bij het Oekraïneverdrag, niet meer zien zitten en nu vol willen inzetten op de gekozen burgemeester. Volgens Wim Voermans is dit het werk van een ‘slechte verliezer’.

Wanneer een baby te vroeg ter wereld komt, telt elke minuut, en elke beslissing. Om artsen te helpen bepalen welke zorg nodig is, onderzocht promovendus Manchu Umarani Thangavela moleculen in bloed en urine die vroeggeboorte en infecties bij pasgeborenen kunnen voorspellen.

Hoe kiezen dieren hun partner? Het antwoord is simpel: alles draait om kwaliteit. Willen wij mensen nog wel eens iets aantrekken wat toevallig in de mode is, dieren doen niets zomaar. Achter een mooi verenkleed of een oor¬verdovend brullen zit maar één boodschap: ik ben in topconditie. De evolutionaire…

Promotor: C.J. ten Cate, Co-promotor: H.W. Slabbekoorn

This thesis explored the molecular pharmacological mechanisms of targeting CB2R via investigation of novel drug discovery concepts such as target binding kinetics, allosteric modulation and biased signaling.

Promotor: M.A.G.J. Orrit

Preterm birth is a major contributor to neonatal morbidity and mortality and is associated with both acute complications and long-term health consequences.

During post-embryonic development into adults, animals face an environment that fluctuates constantly. For example, in nutrient availability, temperature, and osmolarity (e.g., salt concentration).

In this Ph.D. thesis, we characterized two novel upstream regulators of JUB1, HB40, and HB22, in Arabidopsis thaliana. In Chapter 2, we described functions of HB40 in modulating growth and development via the regulation of JUB1 and GA inactivation genes GA2OXs.

Promotor: Carel J. ten Cate, Co-Promotor: Hans W. Slabbekoorn

We study the interplay of topology and geometry with chirality for several passive and active systems, employing both analytical and numerical methods.

Viral hemorrhagic fever (VHF) is a group of acute diseases caused by highly infectious viruses including Ebola, Lassa, Dengue viruses. Its high mortality rate poses high risk to public health, however, studies on VHF have been hampered due to the non-availability of proper models and incomplete knowledge…

Anthropogenic noise has been shown to affect marine animals in various ways, this may have fitness consequences at individual and population level. This thesis aims to increase insight into the quantification of sound-induced behavioural responses that are relevant to fitness, and into factors that…

Prof.dr. J. Memelink

Promotor: B. van de Water

Promotores: A.H. Meijer, H.P. Spaink

This thesis seeks to investigate how cancer-associated mutations affect the pharmacological properties of selected GPCRs—primarily A2AAR and 5-HT2CR—through a combination of ligand binding assays, signaling readouts, kinetic profiling, and cellular functional assays.

Zowel muziek als taal maken gebruik van geluid, waaronder timing en toonhoogte. Terwijl taal voornamelijk semantische betekenis overbrengt, is dat bij instrumentale muziek niet het geval; deze wordt doorgaans gezien als een uitdrukking van emotie. Dit project onderzoekt aan de hand van metaforen in…

Drug development is hampered by the limited predictive value of conventional 2D culture systems, which fail to recapitulate the complexity of the disease microenvironment and contribute to high clinical attrition rates.

Promotor: T. Schmidt, Co-Promotor: B.E. Snaar-Jagalska

This thesis describes the development and optimization of the first molecular tools to study the enzyme PLA2G4E.

Prostate cancer (PCa) is one of the most prevalent cancer in males.

The main aim of this thesis was to unravel the signaling and regulatory networks that drive tumor cell migration during breast cancer metastasis.

Congres/symposium

Promotie

Zit je in havo of vwo 3, 4 of 5 op De Kager in Leiden en ben je benieuwd naar hoe signalen, algoritmes en online cultuur jouw gevoelens en keuzes beïnvloeden? Wil je bovendien weten hoe onderzoek bij Psychologie aan de Universiteit Leiden werkt? Doe dan mee aan deze korte cursus “Aantrekkingskracht…

Promotor: A.P. IJzerman