De EEE-lezingen zijn een maandelijkse interdisciplinaire lezingenreeks waar wereldwijd gerenommeerde en inspirerende denkers en wetenschappers worden uitgenodigd.

This book aims to be a point of reflection and debate for journalists, academics and students to recognize a fundamental task in the duty of the communications professional, which is to influence through their daily work and their routines in order to achieve a more inclusive and plural society, through…

Kunst en vrije tijd, Kunst en vrije tijd

De prof. A.E.J. Modderman Stichting is verbonden aan de Universiteit Leiden en beoogt bevordering van het onderzoek op het gebied van de strafrechtswetenschappen.

Nederlandse politicologen laten hun licht schijnen over het veranderende electoraat.

Op 25 september promoveert Alzenir Mendes Martins de Menezes. Het Leiden University Centre for Linguistics feliciteert Alzenir!

In this thesis an activity-based probe was discovered that could visualize the activity of PLAATs. With an optimized gel-based ABPP assay in hand, screening of a compound library led to the discovery of alpha-ketoamides as a hit for PLAAT3.

An account of the total of material flows going in, out and through Amsterdam.

Promotores: Prof.dr. J.N. Kok, Prof.dr. C.A. Mandemakers, Co-Promotor: G. Bloothooft

Metal complexes and 2D materials like graphene were combined to produce structures that can function as sensors.

Promotor: Prof.dr.ir. J.G.E.M. Fraaije, Co-promotor: A. Kros

Patients share valuable advice and experiences with their peers in online patient discussion groups.

Pulsars were first discovered in 1967 and since then the population has grown and expanded over several wavelengths.

Promotores: T.H. Oosterkamp, N. de Jonge

Accurate prediction of the unbound drug concentration-time profile at the CNS target site is crucial for the assessment of the right drug concentration-effect relationship. PBPK models have supported the PK prediction of the CNS target sites and the translation of PK data between species and between…

To contribute to the body of knowledge aiming at a better coverage of ecosystem service assessment in LCA studies, this thesis dives into the challenges of incorporating existing ecosystem service methods within the impact assessment phase of the conventional LCA framework.

Deze zomer verruilen de jonge Leidse politicologen Feike Fliervoet en Gerrit Krol hun vertrouwde bestaan als werkgroepdocent voor een onderzoeksplek in Florence. Na vele jaren te hebben gewerkt als student en vervolgens docent bij Politieke Wetenschap, worden zij promovendus aan het gerenommeerde European…

Promotores: B. van de Water; P. Hogendoorn; J. Bovée Co-Promotor: E.H.J. Danen

Promotor: Prof.dr. R. Verpoorte, Co-Promotores: N.R. Mustafa, A.E. Schulte

Lysosomal acid glucosylceramidase (GBA1) is a lysosomal enzyme that degrades glucolipids with its main substrate being glucosylceramide (GlcCer). Defects in the GBA1 gene lead to glycosphingolipidosis Gaucher disease (GD), in which the hydrolysis of GlcCer is impaired and therefore, it accumulates in…

Over de sporen die Darwin, hoewel nooit in Leiden geweest, er toch achterliet.

β-Lactamases are enzymes that can break down β-lactam substrates, such as antibiotics, preventing the use of these antibiotics for the treatment of various infectious diseases. However, some compounds, β-lactamase inhibitors, can block these enzymes allowing for possible treatments using a combination…

CREEA is a FP7 project on compiling and refining environmental and economic accounts. The project runs from April 2011 to March 2014.

The main goal of the research described in this thesis was the development of new photoactivated chemotherapy (PACT) ruthenium(II) complexes bearing a non-toxic photolabile ligand.

Solar energy is used by photosynthetic organisms to drive energy required cellular processes. Is absorbed by two groups of pigments, located in the LHCs.

The energy system is at the heart of two of the greatest challenges of the 21st century: decreasing CO2 emissions to meet the ambitions of the Paris agreement while fulfilling the growing energy demand associated with the economic aspirations of a growing world population.

Promotores: S.F. Portegies Zwart, E. M. Rossi

Promotor: Prof.dr. E.F. van Dishoeck, Co-Promotor: M.R. Hogerheijde

Promotores: R. Cramer, A.K. Lenstra, Co-Promotor: B.M.M. de Weger

Promotor: J.S. Kaastra Co-promotor: E. Constantini

Promotor: Prof.dr. H.P. Spaink, Co-promotor: Dr. B.E. Snaar

Promotores: Prof.dr. G.F.A. Kersten, W. Jiskoot, Co-promotor: J-P. Amorij

Promotor: J. van der Greef, T. Hankemeier; Co-promotor: H.A. van Wietmarschen

This thesis aimed to investigate the impact of exposure dynamics, relative contributions of ENPs(particle) and ENPs(ion), and dosing regimens on the toxicity of ENPs varying in different physico-chemical properties, on the composition and functioning of soil microbial communities.

Nanodiscs are small, disc-shaped structures designed to mimic biological cell membranes, composed of a lipid bilayer stabilized by scaffold proteins. Membrane proteins play crucial roles in essential processes such as nutrient and waste transport, molecular recognition, and cell signalling, making them…

The external tissues of plants and animals are colonized by microbial communities termed microbiota. When organisms are exposed to environmental pollutants, these substances will therefore encounter microbiota at the exposure interface.

At the moment, over 350.000 chemicals are registered worldwide for production and use. Their application, however, may harm human health and the environment.

Tijdens de viering van de 54ste Dies Natalis van Universitas Padjadjaran in Bandung, Indonesië, zijn op 9 september 2011 onderscheidingen uitgereikt aan de Leidse prof.dr. L.J. Slikkerveer en drs. L.E.H. Vredevoogd. Zij kregen deze voor hun uitzonderlijke bijdrage aan de succesvolle wetenschappelijke…

LIACS is a partner in the EU Erasmus+ Curriculum Development for the Asian education system. The knowledge available in the field of Data Science and Artificial Intelligence education will be shared and adapted for the Asian market.

The following report discusses a survey on the topic of the Sustainable Development Goals that was distributed among researchers at Leiden University in the month of November 2021.

In summary, the collective results described in this thesis show that nanoparticulate vaccines can be delivered intradermally by coated and hollow microneedles and evoke antigen-specific immune responses.

Promotor: J. Kuiper

Dissolution processes – next to aggregation processes - play an important role for fate prediction and environmental risk assessment of metal-based nanoparticles (MNPs). It is challenging to predict the kinetics of the dissolution process of MNPs in complex systems such as we can find in in vivo and…

Microscopic insight on lipid-based nanomedicine in vivo remains limited to the perception of the knowledge that could be obtained: if we interpret only what we see, then we only believe to know. Although believing to know encapsulates an undefined amount of uncertainty in the exploration of lipid-based…

Wat zijn de belangrijkste thema's in het uitvoeren van systemen voor bio-energie ?

De nieuwe software van Microsoft, VALL-E hoeft maar drie seconden van een stem te horen om hem bijna foutloos te kunnen imiteren. Je kunt zelf kiezen welke emotie de stem moet gebruiken en wat hij moet zeggen. Valerie Frissen, Hoogleraar Digitale Technologie en Sociale Verandering bij eLaw en directeur…

Cholesterol influences many pathways, including serving as precursor for adrenal steroidogenesis. Imbalance of cholesterol levels has been implicated in several diseases including cardiovascular diseases and its underlying pathology, atherosclerosis.