Promotores: Prof.dr. T.H.W. Bäck, Prof.dr. M.R.V. Chaudron, Co-Promotor: M.T.M. Emmerich

Nucleoid associated proteins maintain the architecture of the bacterial chromosome and regulate gene expression, hinting that their role as transcription factors may involve local three-dimensional chromosome re-modelling.

Waarom is er geen Noordoost Aziatische veiligheidsstructuur? In dit artikel, gepubliceerd in The Pacific Review, bespreken auteurs Wang (Peking University) en Stevens (Leiden University) de vier obstakels voor coöperatie in Oost Azië.

Atoms and molecules are the basic units of matter. If we keep dividing a bar of gold or a glass of water into smaller parts, at the end we are left with a single gold atom or a water molecule.

This thesis examines enzyme domain architecture and engineering to improve the breakdown of lignocellulose and starch, abundant biopolymers crucial for sustainable biofuel and biochemical production. Carbohydrate-active enzymes (CAZymes) facilitate this degradation, but the structural complexity of…

The Department of Architecture of KU Leuven is looking for two full-time PhD students (48 months) for the ERC-funded project "URBAN-DELTA: Metropolises in the Mud. Innovation in Delta Building Technology in Europe and China before 1800", directed by Merlijn Hurx. Apply before: June 10

The AT-Hook Nuclear Localized 15 (AHL15) gene belongs to a plant-specific gene family of DNA-binding proteins. Overexpression of AHL15 in Arabidopsis thaliana delays developmental phase transitions whereas its loss of function causes a slight acceleration.

In June, the international conference "Practices of Copying and Imitation in Early Modern Architecture (1400-1700)" will take place at Ghent University. This conference seeks to direct attention to verifiable practices and material documentation of copying and imitation in the workshop and on the building…

In design optimization problems, engineers typically handcraft design representations based on personal expertise, which leaves a fingerprint of the user experience in the optimization data. Thus, learning this notion of experience as transferrable design features has potential to improve the performance…

This thesis aimed to investigate core cross-linked polymeric micelles (CCPMs) and expand their potential for the delivery of hydrophobic drugs and co-factors.

The thesis explores how interstellar chemistry evolves as a function of time and changing physical architectures during the formation of stars.

Paradiso, de Keizersgrachtkerk en het Artis-aquarium: deze gebouwen danken alle hun ontwerp aan architecten Gerlof Bartholomeus Salm en Abraham Salm. Remco van der Kuijp deed onderzoek naar de plek van vader en zoon in de architectuurgeschiedenis. Promotie op 25 maart.

Promotie

Lezing

The European Council and the European Commission have a similar role in agenda setting. Both place issues on the EU agenda. However, these institutions have distinct designs. They have different political attributes (the European Council has considerably more political authority) and information-processing…

Errors are everywhere, and mechanical failures are especially common: buckled grain silos and cracked support columns are, justly, seen as an issue to be avoided.

In this thesis I highlight the applications of Oxford Nanopore Technologies (ONT) sequencing. This technique is a relatively new approach in the sequencing field, where nanopores are embedded in a membrane, DNA molecules are pulled through nanopores and an electrical current serving as the sequencing…

Constraint multi-objective optimization with a limited budget for function evaluations is challenging. This thesis tackles this problem by proposing new optimization algorithms. These algorithms are applied on holistic ship design problems. This helps naval architects balance objectives like cost, efficiency,…

Utilizing the polymeric platform of polypept(o)ides, this thesis describes synthesis and investigation of novel triblock copolymers to obtain carrier systems with multiple compartments for efficient siRNA delivery. Although the individual microstructure of nanoparticles differs depending on the polymeric…

Time-series forecasting through modelling sequences of temporally dependent observations has many industrial and scientific applications. While machine learning models have been widely used to create time-series forecasting models, creating efficient and performant time-series forecasting models is…

Promotor: Prof.dr. S. Portegies Zwart

Streptomyces bacteria are a valuable source of natural products, many of which are used in the clinic or in biotechnology.

Biopolymer sequencing with graphene edge-based tunnel junctions has the potential to overcome current limitations with the third generation of sequencing based on biological nanopores.

Even though more than 4000 extra-solar planets are known today, only a small fraction of these has been captured in an image. To better understand the planet formation mechanisms in solar-like environments we started the Young Suns Exoplanet Survey (YSES).

In this work, we illustrate unconventional approaches towards the fabrication of edge functionalized graphene nanostructures and bidimensional architectures in polymeric and metallic supports, with an outlook towards molecular sensing devices.

Promotores: Prof.dr. J.N. Kok, Prof.dr. M.R.V. Chaudron (Chalmers Univ., Sweden)

Streptomyces are multicellular, Gram-positive bacteria in the phylum of actinobacteria which produce a high amount of bioactive natural products of which the expression is tightly coordinated with the life cycle.

This thesis explores how electron paramagnetic resonance (EPR) spectroscopy can be used to investigate key biochemical processes.

Pharmaceutical companies, governments and the general public have become increasingly aware that animal models used in drug testing lack vital aspects to serve as an accurate representation of human biology. As models of the human body should become more physiologically relevant, animal models no longer…

In Mykeens Griekenland verschenen vanaf 1600 v. Chr. zeer veel monumentale bouwwerken zoals grote graftombes. Waarom stopte die bouwlust 400 jaar later abrupt? Archeoloog Ann Brysbaert onderzoekt de mogelijke oorzaken dankzij haar ERC Consolidator Grant.

In 2021 heeft het NCSC de Universiteit Leiden gevraagd om een rapid review uit te voeren naar best practices en mogelijkheden voor vervolgonderzoek over de integratie van gedragswetenschappen in security by design methodologieën en projecten. Dit academische veld wordt security by behavioural design…

Bacteria often experience external challenges, such as changes in environmental conditions or attacks by bacteriophages.

We have studied shape with a particular focus on the zebrafish model system. The shape is an essential appearance of the phenotype of a biological specimen and it can be used to read out a current state or response or to study gene expression.

Promotor: Prof.dr. M. Schilthuizen

Mechanical metamaterials are man-made materials which derive their unusual properties from their structure rather than their composition.

Plant architecture has distinct forms in different plant species, but also within a species the finalarchitecture of a plant is determined by its gradual development and changes therein induced by environmental conditions during the plant’s life cycle.

Over several decades, a variety of computational methods for drug discovery have been proposed and applied in practice. With the accumulation of data and the development of machine learning methods, computational drug design methods have gradually shifted to a new paradigm, i.e. deep learning methods…

Kennis van moslimsamenlevingen is onmisbaar om in een geglobaliseerde wereld te kunnen functioneren en om onze eigen Nederlandse maatschappij goed te begrijpen. In Leiden verdiepen onderzoekers zich in de talen, cultuur, religie, rechtssystemen en geschiedenis van moslimsamenlevingen en zetten daarmee…

Promotie

Promotie

Hybrid zones occur where two species meet and produce offspring (hybrids). Typically, hybrids show a considerable reduction in fitness. In this thesis two hybrid zones are treated.

Sigrid de Jong en Grantley McDonald hebben ieder een Studieprijs van de Stichting Praemium Erasmianum gekregen voor hun proefschrift.

De 22-jarige Wendy Gunther is de eerste student van de Master ICT in Business die summa cum laude is afgestudeerd. Zij kreeg een 9 voor haar scriptie en behaalde een 9 gemiddeld op de vakken die zij volgde. Op vrijdag 26 september nam zij haar bul in ontvangst in het Academiegebouw in Leiden.

Binnen het onderzoeksproject "Governing and Building the City: Mirrors for Magistrates as a Lieu for Theoretical Reflection on Architecture" lopen er momenteel twee vacatures voor een doctoraatsstudent en een post-doctoraal onderzoeker. Kandidaten kunnen solliciteren tot 15 mei 2024.

Stefan Manegold is benoemd tot hoogleraar Data Management aan de Faculteit der Wiskunde en Natuurwetenschappen van de Universiteit Leiden. Het betreft een part-time aanstelling voor een dag per week bij het Leiden Institute of Advanced Computer Science (LIACS) en het Leiden Centre of Data Science (LCDS).…

Handbook of Signal Processing Systems is organized in four parts. The first part motivates representative applications that drive and apply state-of-the art methods for design and implementation of signal processing systems; the second part discusses architectures for implementing these applications;…

'Als componist ben ik altijd bezig met tijd. Tijd is, naast klank, het transportmiddel van de kunst die ik beoefen.'

Archeoloog Victor Klinkenberg onderzocht een oude Assyrische nederzetting in Syrië, dichtbij IS-bolwerk Raqqa. ‘Al met al speelde het sociale leven een veel grotere rol dan het militaire.’ Promotie op 27 oktober.

Join us in Canterbury and online on the 13th and 14th June for the eleventh annual MEMS Festival at the University of Kent. We welcome papers on a range of topics within medieval and early modern studies for this interdisciplinary conference. Deadline for abstracts, 4th of April.