Promotores: C.A.M.J.J. van den Hondel, V. Meyer, Co-promotor: A.F.J. Ram

Promotor: Prof.dr. G.P. van Wezel

Bacteria are highly complex and diverse organisms that have adapted to survive in ecological niches ranging from the most extreme to the most heterogeneous environments.

Actinobacteria are Gram-positive bacteria that have a complex multicellular life cycle and are well known for their ability to produce a wide range of bioactive natural products (NPs).

Promotores: Prof.dr. C.A.M.J.J. van den Hondel, Prof.dr. V. Meyer (Technische Universität Berlin)

The idea of citizens and public professionals collaborating to provide public services has widely spread in several countries around the globe. Co-production is often presented as the go-to solution for challenges like a legitimacy crisis of both the government and the market, and financial concerns.…

Factors affecting galanthamine production in Narcissus

This thesis examines the impacts and challenges of water use of electric power system. This thesis found that there are large differences in water use of electricity technologies, with hydropower and thermal power being two large water users.

Streptomyces bacteria are a valuable source of natural products, many of which are used in the clinic or in biotechnology.

Promotor: W. Jiskoot, Co-promotor: H.A. Every

Streptomyces are prolific producers of enzymes and secondary metabolites, including more than 50% of all clinical antibiotics. This makes them highly attractive for medical, biotechnological, and industrial purposes.

Filamentous Actinobacteria, such as Streptomyces, produce a plethora of chemically diverse bioactive metabolites that have found applications across medicine, agriculture and biotechnology.

Promotor: G.P. van Wezel, Co-Promotor: E. Vijgenboom

Promotors: Prof.dr. P.J. Punt, Prof.dr. C.A.M.J.J. van den Hondel

Op 15 april promoveert Shaoyu Wang. Het Leiden University Centre for Linguistics feliciteert Shaoyu!

Het project onderzoekt hoe tweetalige sprekers omgaan met lexico-syntactische kenmerken – waaronder grammaticaal geslacht, classifiersystemen en de lineaire volgorde van adjectieven en naamwoorden – in het Spaans en het Chinees, zowel in eentalige als tweetalige contexten.

Streptomyces are filamentous bacteria that produce more than two-thirds of known antibiotics.

Plants are colonized by an astounding number of microorganisms that can provide different life-support functions, including nutrient acquisition and protection against (a)biotic stresses like drought or pathogen attack.

Promotor: G.P. van Wezel, Co-promotor: D. Claessen

The soil-dwelling, filamentous bacteria of the genus Streptomyces are renowned for their production of useful secondary metabolites including antibiotics. The work described in this thesis provides new insights on the role and regulation of antibiotic production and resistance in these bacteria.

Bacterial biocatalysis constitutes a sustainable alternative for high-value chemicals production by enabling the utilization of renewable feedstocks.

The intradermal administration route is attractive for vaccine delivery, because of the highly populated antigen-presenting cells in the skin. However, the skin’s main physical barrier, the stratum corneum, prevents vaccines from entering the skin.

Het BOCA-project verkent nieuwe vormen van het communiceren van academische kennis als een manier om de band tussen de universiteit en de samenleving te versterken.

Promotor: G.P. van Wezel

The transition to electric vehicles (EVs) reduces vehicle emissions to combat climate change. EVs raise concerns regarding the production of lithium-ion batteries and related emissions; while batteries can also provide energy storage services for the electricity system.

The global agri-food system plays a critical role in food security and environmental issues.

Promotor: Prof.dr. E. Bouwman, Co-promotor: S. Bonnet

Striga hermonthica, commonly known as witchweed, infests major cereal crops in Sub-Saharan Africa causing severe yield losses and threatening the livelihood of millions of resource poor farmers.

Promotor: A. Achúcarro, Co-promotor: A. Boyarsky

Humanity stands at a pivotal juncture, facing the dual challenge of environmental sustainability and rapid population growth, projected to exceed 11 billion by century’s end.

Plants and their pollinators form complex interaction networks. Within these networks, species differ widely in the number of species they interact with.

This thesis studied in depth the energy use and CO2 emissions of the industrial sector in China.

Actinobacteria are well known for the production of bioactive natural products, many of which have applications in the fields of human, animal and plant health. Subject of this thesis are the anthracyclines, glycosylated aromatic polyketides with potent anticancer activity.

Promotor: Prof.dr. R. Verpoorte, Co-Promotores: N.R. Mustafa, A.E. Schulte

To meet the rising demand for minerals driven by the global shift to clean energy technologies, ensuring responsible and resilient supply chains is critical. Minerals like cobalt, lithium, and nickel for batteries, neodymium and zinc for wind turbines, and indium for solar panels are essential.

Catharanthus roseus (Madagascar periwinkle) produces valuable monoterpenoid indole alkaloids (MIAs) such as vincristine and vinblastine, crucial for cancer treatment.

Cardiovascular disease is the leading cause of death worldwide.

Industrial manufacturing processes, such as the production of steel or the stamping of car body parts, are complex semi-batch processes with many process steps, machine parameters and quality indicators.

Klaprozen verspreiden elk jaar zaadjes die uitgroeien tot een nieuwe generatie bloemen. Soms wacht een deel van de zaadjes een paar jaar, bijvoorbeeld als ze bedekt raken onder een zandlaag. Ze ontkiemen dan pas als het zand verdwenen is. Promovendus Margriet Oomen deed wiskundig onderzoek naar de invloed…

This thesis aimed to investigate core cross-linked polymeric micelles (CCPMs) and expand their potential for the delivery of hydrophobic drugs and co-factors.

The studies described in this thesis deal with glycosidases, in particular alpha-galactosidases.

This thesis examines silicon pore optics (SPO), a technology that exploits silicon wafers from the semiconductor industry to create extremely high quality X-ray optics, by studying its manufacturing process, applications, and prospects.

Food security is challenged by a growing global population and by climate change. Drought and soil salinity are considered the most important ones that inhibit crop yield and distribution. Worryingly, climate change is predicted to increase not only their frequency and severity, but also their co-occurrence,…

Promotor: G. J. Kroes

This thesis explores squaramide-based supramolecular polymers and hydrogels, enhancing their mechanical strength for 3D cell culture.