10,000 zoekresultaten voor “leiden” in de Publieke website
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Multi-dimensional feature and data mining
In this thesis we explore machine and deep learning approaches that address keychallenges in high dimensional problem areas and also in improving accuracy in wellknown problems. In high dimensional contexts, we have focused on computational fluid dynamics (CFD) simulations.
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DNA expressions - A formal notation for DNA
Promotores: J.N. Kok, H.J. Hoogeboom
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Quantumcomputers
Algoritmen ontwerpen is een van de onderzoeksonderwerpen waar Leiden sterk in is. Want supercomputers moeten niet alleen gebouwd worden, maar ook geprogrammeerd. Wetenschappers van internationale faam doen hier onderzoek naar.
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Student-teachers' commitment to teaching
De motivatie van studenten van lerarenopleidingen voor het beroep van leraar is afhankelijk van diverse factoren. Lerarenopleidingen kunnen de betrokkenheid van hun studenten beïnvloeden.
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Freezing conditions in warm disks: snowlines and their effect on the chemical structure of planet-forming disks
This thesis focusses on the temperature structure in protoplanetary disks. The relation between structures seen in the dust and gas-phase molecules is investigated.
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Graphing formulas by hand to promote symbol sense: Becoming friends with algebraic formulas
Het belangrijkste doel van dit onderzoek was het bevorderen van de aspecten van de symbol sense die studenten in staat stellen algebraïsche formules te doorzien en niet-standaard algebra problemen aan te pakken.
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Sociale Wetenschappen
De Faculteit der Sociale Wetenschappen combineert hooggekwalificeerd onderzoek en uitstekend onderwijs in de disciplines culturele antropologie, pedagogische wetenschappen, politieke wetenschap, psychologie, wetenschaps- en techniekstudies, evenals in multidisciplinaire benaderingen.
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Structural changes in single chromatin fibers induced by tension and torsion
Promotor: T. Schmidt, Co-promotor: S. J.T. van Noort
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citizen science voor kinderen
Bij Erfgoed Gezocht Junior maken basisschoolleerlingen kennis met wetenschap en doen zelf archeologisch onderzoek
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Long term dynamics of stochastic evolution equations
Promotor: S.M. Verduyn Lunel, Co-promotor: O. van Gaans
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Reconstructing Magnetic Fields of Spiral Galaxies from Radiopolarimetric Observations
Promotor: H.J.A. Röttgering, Co-promotor: M. Haverkorn
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Reverse engineering of drug induced QT(c) interval prolongation: Towards a systems pharmacology approach
Promotor: M. Danhof Co-promotor: O.E. Della Pasqua
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Fire and grazers in the West African savanna
Promotores: H.A. Udo de Haes, H.H.T. Prins, Co-promotor: H.H. de Iongh
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Synthesis of oligosaccharide libraries from GBS capsular polysaccharides for structure-based selection of vaccine candidates
Glycoconjugate vaccines are composed of microbial poly- or oligosaccharides covalently linked to a carrier protein.
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Functional characterization and unraveling the Gene Regulatory Networks (GRNs) of HD-Zip transcription factor HB40 (and HB22) in Arabidopsis
In this Ph.D. thesis, we characterized two novel upstream regulators of JUB1, HB40, and HB22, in Arabidopsis thaliana. In Chapter 2, we described functions of HB40 in modulating growth and development via the regulation of JUB1 and GA inactivation genes GA2OXs.
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North Sea noise in the Anthropocene: an impact study of human-made impulsive sounds on free-ranging cod
Sound is everywhere in the marine environment and hearing is therefore a very important for stimuli for fish. They use sound for orientation and communication, during migration, aggregation and spawning, but also for detection of prey and predators.
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Split Jacobians and Lower Bounds on Heights
This thesis deals with properties of Jacobians of genus two curves that cover elliptic curves.
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Spin dynamics in general relativity
Promotor: J.W. van Holten
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Stochastic and Deterministic Algorithms for Continuous Black-Box Optimization
Continuous optimization is never easy: the exact solution is always a luxury demand and the theory of it is not always analytical and elegant.
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Phase separation in lipid-based nanoparticles: exploring the nano-bio interface
This doctoral thesis is an effort to understand how lipid phase-separation induced by diacylglycerol analogues in lipid-based nanoparticles affects their in vivo behavior, leading to specific nanoparticle-protein communications and selective cell targeting.
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Diversiteit en inclusie bij de faculteiten
Het Expertisebureau D&I werkt nauw samen met de faculteiten van de Universiteit Leiden.
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Cosmic particle acceleration by shocks and turbulence in merging galaxy clusters
In this thesis, I study the formation of large-scale structure and the physics of particle acceleration at large scales (~Mpc).
- MS Cognitietour: Deventer
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Gene networks-based mechanistic assessment of drug-induced organ toxicity: a focus on liver and kidney
Drug induced organ toxicity is the main problem of the drug development and drug usage in the clinic. The liver and kidneys are the most sensitive organs towards drug induced toxicity.
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Dynamical Gibbs-non-Gibbs transitions and Brownian percolation
Promotor: Prof.dr. W.Th.F. den Hollander, Co-promotor: R. Fernandez.
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Katholiek in de Republiek - De belevingswereld van een religieuze minderheid 1570-1750
Door de katholieke gemeenschap vanuit een aantal vernieuwende invalshoeken te benaderen, belicht dit boek hoe Noord-Nederlandse katholieken op inventieve wijze hun geloof en cultuur levend hielden, zowel in de privésfeer als in het publieke domein.
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Chemical tools to modulate endocannabinoid biosynthesis
Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt
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Development of highly accurate density functionals for H2 dissociation on transition metals
Metals surfaces form a group of effective catalysts for the reaction of small molecules such as hydrogen (H2).
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The tension between nature conservation and economic valuation of ecosystem services
Promotores: G.R. de Snoo, W.T. de Groot, Co-promotor: C.J.M. Musters
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Geometric phases in soft materials
Geometric phases lead to a nontrivial interference result when an electron's different quantum mechanical paths choices encircle a magnetic coil in an Aharonov-Bohm experiment.
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A pharmacognostic study of Vernonia guineensis Benth. (Asteraceae): bioactivity, safety, and phytochemical analysis
Promotor: Prof.dr. R. Verpoorte, Co-Promotor: Dr. Young Hae Choi
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Innate immune modulation in atherosclerosis and vascular
Promotores: Prof.dr. J. Kuiper, Prof.dr. P.H.A. Quax, Co-promotor: I. Bot
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Principal algebraic actions of the discrete Heisenberg group
Promotor: Prof.dr. W.T.F. den Hollander
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Regulation of the arabidopsis AGC kinase PINOID by PDK1 and the microtubule cytoskeleton
Plants, are sessile organisms, have developed strategies to adapt to changes in their environment, in part by altering their growth and development.
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Tuning in to the feedback bassline: revealing the operation of AGNs in galaxy clusters with high-resolution radio observations
Following the Big Bang, structure in the Universe started collapsing under the force of gravity. This resulted in the formation of the first stars, galaxies and clusters of galaxies.
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On the amount of sieving in factorization methods
Promotoren: R. Tijdeman, A.K. Lenstra, Co-promotor: H.J.J. te Riele
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Games: homo ludens in actie
Gamen is vaak veel leuker dan huiswerk maken, maar stel: je maakt van je huiswerk een game, is het huiswerk dan ook leuker? En leer je er dan nog net zo veel van?
- Over Annie Romein-Verschoor
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Alumni
Universiteit Leiden is trots op haar alumni. Alumni dragen op allerlei manieren bij aan de groei en bloei van de universiteit. De universiteit zet zich in om ook na het afstuderen bij te dragen aan de persoonlijke en professionele ontwikkeling van haar alumni.
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Biomimetic models of [NiFe] hydrogenase for electrocatalytic hydrogen evolution
The growing demand of energy indicates that global energy resources in the form of fossil fuels will not be sufficient in the future. In order to solve potential future energy problems development of a sustainable hydrogen economy is highly desirable.
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Molecular engineering of plant development using Agrobacterium-mediated protein translocation
Supervisor: P.J.J. Hooykaas Co-Supervisor: R. Offringa
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PLGA-based particulate vaccine delivery systems for immunotherapy of cancer
Promotores: W. Jiskoot, F. Ossendorp
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Onderwijs
De afdeling Bedrijfswetenschappen verzorgt bedrijfswetenschappelijk onderwijs voor studenten van de Faculteit der Rechtsgeleerdheid, maar ook voor studenten van andere faculteiten van de Universiteit Leiden.
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Systems pharmacology of the amyloid cascade
According to the amyloid cascade hypothesis, accumulation of beta-amyloid (Aβ) peptides initiates the pathological cascade in Alzheimer's disease (AD).
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Atomic Insights into Hydrodesulfurization
Hydrodesulfurization (HDS) is an ubiquitous part of oil refining that ensures that fuels are cleaned of impurities and environment release of pollutants such as SOx and NOx gasses are minimized.
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Nano-scale electronic structure of strongly correlated electron systems
In condensed matter systems electron-electron interactions, negligible in everyday metals, can dramatically alter the electronic behavior of the system. Examples of such altered behavior include high-temperature superconductivity and modulation of the electron density.
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Intermittency and Number Expansions for Random Interval Maps
This dissertation consists of two parts, each of which considers a different research area related to random interval maps. In the first part we are interested in random interval maps that are critically intermittent.
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Molecular inheritance from cloud to disk: a story of complex organics and accretion shocks
Stars like the sun are born in large molecular clouds existing from gas and dust. During the formation process, the chemical composition of the material can be altered drastically by the changing physical conditions.
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Morphogenesis and heterogeneity in liquid-grown streptomyces cultures
The filamentous bacteria Streptomyces are widespread inhabitants of terrestrial soils.
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Sensing Transport
Solute carrier (SLC) transporters are a large and diverse class of relatively understudied transmembrane proteins.