962 zoekresultaten voor “cancer drug discovery initiative” in de Publieke website
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Identification of regulators of cancer - immune interactions
Promotie
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Dissecting the immune microenvironment of breast cancer
Promotie
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Lateral Lymph Nodes in Rectal Cancer
Promotie
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Formulation of Peptide-Based Cancer Vaccines
Promotie
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Roxanne Kieltyka
Wiskunde en Natuurwetenschappen
r.e.kieltyka@chem.leidenuniv.nl | +31 71 527 4441
- Drugs & geschiedenis
- Drugs & medicijnen
- Drugs & biologie
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Tailored treatment for colon and rectal cancer
Promotie
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Verblijfstijd geneesmiddel op doelmolecuul even belangrijk als ‘klik’
Niet alleen de ‘klik’ van een geneesmiddel met het doelmolecuul in het lichaam bepaalt de werking ervan, maar ook de tijd die het geneesmiddel op het molecuul doorbrengt. Leidse onderzoekers gaan met 15 miljoen euro een Europees consortium leiden om vanuit dit nieuwe concept betere medicijnen te mak…
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Genetic and lifestyle factors in breast cancer prognostication
Promotie
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Plan B for particle physics: finding long lived particles at CERN
This thesis discusses the discovery potential of Intensity Frontier experiments.
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Erik Danen wil tumoren vangen in hun eigen web
Erik Danen speurt met succes naar wegen om tumoren die slecht op medicijnen reageren de pas af te snijden. De hoogleraar Cancer Drug Target Discovery kijkt hiervoor naar de interactie tussen tumorcellen en hun omgeving. Oratie vrijdag 10 mei.
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Structural and functional analysis of proteins involved in natural product biosynthesis and morphological differentiation in Streptomyces
Streptomyces present a valuable platform for natural product discovery. Lugdunomycin is a novel angucycline-derived polyketide from Streptomyces sp QL37, with unprecedented skeleton and antimicrobial activity.
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Causal Discovery: Challenges and Opportunities
Lezing
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Discovery and characterization of new glucosylated metabolites
Promotie
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Discovery of Reversible Monoacylglycerol Lipase Inhibitors
Promotie
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Prediction of contralateral breast cancer - Statistical aspects and performance assessment
Promotie
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Esther Huiskers-Stoop en Diego Quiñones Cruz geven presentatie over Cooperative Compliance voor ontwikkelingslanden aan de OESO
De organisatie voor Economische Samenwerking en Ontwikkeling (OESO) heeft in samenwerking met het Inter-American Center of Tax Administrations (CIAT) op 27 november 2023 een wereldwijde online Tax Morale Workshop georganiseerd, waar Esther Huiskers-Stoop van de Universiteit Leiden en Diego Quiñones…
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Spectroscopic characterization of exoplanets: From LOUPE to SINFONI
Over the past years it has been discovered that the population of extra-solar planets is large and diverse.
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Witnessing the Process of Bacterial Cell Death: Novel Antimicrobials and Their Mechanisms of Action
This thesis describes the antimicrobial discovery strategy developed in our group, the den Hertog Group at the Hubrecht Institute. It includes a cultivation-based screening approach for novel antimicrobial agents from the source of fungi, and a bacterial time-lapse imaging approach for antimicrobial…
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Eregalerij 2022
In 2022 hebben medewerkers en studenten van de Universiteit Leiden veel mooie prijzen gewonnen en belangrijke onderzoekssubsidies binnengehaald.
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Discovery of selective diacylglycerol lipase β inhibitors
Promotie
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Immuno-photodynamic therapy of cancer
Promotie
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Experimental optical imaging during pancreatic cancer interventions
Promotie
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Optimizing clinical management of T1 colorectal cancer
Promotie
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Harnessing neoantigens for targeted cancer treatment
Promotie
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Exploring the chemical space of post-translationally modified peptides in Streptomyces with machine learning
The ongoing increase in antimicrobial resistance combined with the low discovery of novel antibiotics is a serious threat to our health care.
- Drugs & kunst/literatuur
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Shaping the pharmacokinetic landscape for renally cleared antibiotics in obesity
The prevalence of obesity (BMI >40 kg/m2) has increased rapidly over the recent years, not only in adults, but also in children and adolescents.
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Synthetic carbohydrate ligands for immune receptors
One of the main challenges in the development of an effective anti-cancer vaccine is the generation of an adequate and directed cellular immune response.
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Click-to-release for immune cell activation
This work describes the use of click-to-release chemistry to get spatiotemporal control over immunocytokine activity. Until now, immunocytokines (cytokines coupled to a tumor-targeting-moiety) remained active throughout the body, being able to bind their respective receptors, causing mild to severe…
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Mechanisms of Ewing sarcoma metastasis
Promotor: T. Schmidt, Co-Promotor: B.E. Snaar-Jagalska
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Leukemia treatment & cognitive development
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Inhibitors and activity-based probes for β-D-glucuronidases, heparanases and β-L-arabinofuranosidases
Glycosidases (GHs) are enzymes responsible for the degradation of carbohydrates and play many roles in human health and pathophysiology. Often, abnormal levels of glycosidase activity are markedly linked to human pathologies.
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Development of hyaluronan-based dissolving microneedle arrays for dermal vaccination
Dissolving microneedles are a subgroup of microneedle types that completely dissolve within the skin. During this dissolving process the vaccine, stored in the needle matrix, is released into the skin.
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Ewa Snaar-Jagalska benoemd tot hoogleraar Cellulaire tumorbiologie
Met ingang van 1 april is Ewa Snaar-Jagalska benoemd tot hoogleraar Cellulaire tumorbiologie aan het Instituut voor Biologie, onderdeel van de Universiteit Leiden.
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Unfolding the regulation of stress response pathways upon liver injury
Drug-induced liver injury (DILI) is one of the main reasons for drug attrition during pre-clinical and clinical phases of drug development as well as for drug withdrawal post-marketing.
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Unraveling mucin type o-glycosylation signatures of colorectal cancer
Promotie
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Characterization of candidate genes in unexplained polyposis and colorectal cancer
Promotie
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Improving Diagnostic, Prognostic and Predictive Biomarkers in Colorectal Cancer
Promotie
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The tumor-stroma ratio in epithelial cancer types
Promotie
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Early Detection of Pancreatic Cancer in High-Risk Individuals
Promotie
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Towards personalized treatment for high risk endometrial cancer
Promotie
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Quality assessment and multi modalty in gastric cancer treatment
Promotie
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Understanding the complexity of TGF-beta signaling in cancer
Promotie
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Refining individualized treatment in older patients with breast cancer
Promotie
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Diagnostic challenges of today's lung cancer pathology
Promotie
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In vitro and in vivo delivery of functionalized nanoparticles via coiled-coil interactions
Promotor: A. Kros, Co-promotor: R.R.C.L. Olsthoorn
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Mesoporous silica nanoparticle-based protein delivery systems for biomedical applications
Promotor: A. Kros