1,829 zoekresultaten voor “modelling ” in de Publieke website
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Nature, nurture and neural mechanisms of social emotion regulation in childhood
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Evolutionary diversification and historical biogeography of Orchidaceae in Central America with emphasis on Costa Rica and Panama
In this thesis, I targeted the orchid genus Lepanthes, one of the six genera of angiosperms that surpasses 1,000 species in the Neotropics, as a study model to investigate the evolutionary processes that promoted species diversifications.
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Substances from Cradle to Grave
Materials balances have been used in the recent past for the analysis of substance oriented environmental problems and the formulation of measures for environmental policy. In this study an integrated tool, based on the materials balance principle, has been developed for the analysis of both environmental…
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Solving multiplication and division problems
Latent variable modeling of students' solution strategies and performance
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Systems pharmacology of the endocannabinoid system
In this thesis, a system pharmacology approach, integrating metabolomics, pharmacology and chemical biology, was applied to understand and modulate the endocannabinoid system across different model systems (cells, zebrafish, mice and humans).
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Microfluidic 3D cell culture for high throughput screening
There is an urgent need for more physiologically relevant cell culture methods to guide compound selection in pre-clinical stages of the drug development pipeline.
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How to scale clearance from adults to children for drugs undergoing hepatic metabolism?
The aim of this thesis is to expedite and ensure the systematic accuracy of clearance scaling from adults to paediatric patients, with a special focus on drugs undergoing hepatic metabolism.
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Enlightening the Primordial Dark Ages
This thesis is dedicated to the exploration of the primordial dark ages: unknown physics during the earliest stages of the Universe’s expansion that have not yet been directly probed by observations. Cosmic inflation is a burst of exponential expansion of space after the “Big Bang”.
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The individual level effect of symbolic representation: An experimental study on teacher-student gender congruence and students’ perceived abilities
Onderzoek naar representatieve bureaucratie heeft vaak de positieve prestatie-effecten bevestigd van bureaucratieën die de demografische kenmerken van hun cliënten weerspiegelen. Er is echter weinig bekend over de onderliggende mechanismen op individueel niveau die tot deze resultaten leiden.
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The Anthropomorphic Hegemony of Subjectivity: Critical Reflections on Law and the Question of the Animal
Op 16 december 2019 verdedigde Jan-Harm de Villiers zijn proefschrift 'The Anthropomorphic Hegemony of Subjectivity: Critical Reflections on Law and the Question of the Animal'. Het promotieonderzoek is begeleid door promotor prof.dr. P. Cliteur.
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Corporate venture management in SMEs: evidence from the German IT consulting industry
Promotor: Prof.dr. B.R. Katzy, Prof.dr. H.J. van den Herik, Prof.dr. G.H. Baltes (University of Applied Sciences Konstanz)
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Stap 4. Vergelijken en beslissen
Hoe maak je nu de definitieve keuze voor een masteropleiding?
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Does it still hurt?
The last decades it is increasingly recognized that acute as well as chronic postoperative pain is an important problem. Treatment and prevention of postoperative pain is a challenge, especially in special patient populations where there is only limited guidance on how to optimally use opioids.
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Morphodynamic equilibria in tidal inlet systems: sensitivity to geometrical variations
A tidal basin is an inland sea which is almost entirely enclosed by land and connected to the open sea by a tidal inlet. Through the tidal inlets interaction takes place between the tidal basin and the open sea.
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Systems diagnosis of chronic diseases, explored by metabolomics and ultra-weak photon emission
Promotor: J. van der Greef; Co-promotor: E. van Wijk, M. Wang
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Towards a mechanistic understanding of nanoparticle behavior using zebrafish
The work described in this dissertation contributes to a better mechanistic understanding of nanoparticles in vivo. To achieve that goal, we used the zebrafish as a highly predictive pre-screening model of nanoparticles.
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Evolution and development of orchid flowers and fruits
To gain more insight into the evolutionary development of orchid flowers and fruits, the orchid species Erycina pusilla was studied. The evolutionary origin of the median petaloid sepal, the callus on the labellum, and the stelidia was studied.
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Assistant/Associate professor in Quantitative Ecology (0.8-1.0 fte)
Wiskunde en Natuurwetenschappen, Centrum voor Milieuwetenschappen Leiden (CML)
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Fluorescent in vivo models for hematopoietic stem cell and lymphoid lineage analysis
Promotie
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Experimental pain models for the evaluation of next-generation analgesics in clinical pharmacology studies
Promotie
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In vitro models of bone-forming tumours: from target to treatment
Promotie
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Advanced tools and methods for modeling cardiovascular disease using human pluripotent stem cells
Promotie
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Patient derived zebrafish xenograft models for personalized treatment of uveal melanoma
Promotie
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epidemiologic methods on findings in studies of causal effects and prediction modelling
Promotie
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EuDEco Report on the legal analysis (D2.2)
D2.2 comprises the in-depth legal analysis of the initial heuristic model, focused on addressing, in more detail, the main legal concerns for data reusers in the European data economy. This detailed analysis of the legal propositions presented in D2.1 is supplemented by an analysis of the technological,…
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Topics in mathematical and applied statistics
Promotor: A.W. van der Vaart
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Innovative (electro-driven) sample preparation tools for metabolomics study of muscle aging
This thesis focuses on the development of sample-preparation methods for small amounts of samples and applying the developed methods to muscle tissues to investigate the mechanisms involved in sarcopenia.
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Assessing the link between television consumption and the attitudes toward people living with HIV/AIDS in Chile
We analyse the link between media consumption and the attitudes toward people living with HIV/AIDS in Chile. We used data from a sample of 1000 people, obtained in the 2011 wave of the World Values Survey (WVS). We use a logistic binary regression model by maximum likelihood. Our results suggest that…
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Single-molecule microscopy in zebrafish embryos
Single-Molecule Microscopy (SMM) techniques constitute a group of powerful imaging tools that enable researchers to study the dynamic behavior of individual molecules.
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Lezingen bij Science
Van zwarte gaten tot kunstmatige intelligentie en van medicijnonderzoek tot data science: welkom in de fascinerende wereld van de Faculteit der Wiskunde en Natuurwetenschappen. Geregeld geven onze onderzoekers, studenten en gasten publieke lezingen over hun werk. U bent van harte uitgenodigd.
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Search for cosmic neutrinos with ANTARES
Promotor: Prof.dr. M. de Jong, Co-Promotor: A.J. Heijboer
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Exploring the mechanisms of metastatic onset for novel treatment strategies
This thesis represents a comprehensive investigation into the control of cancer stemness and metastatic initiation using a combination of advanced zebrafish xenograft models and in vitro assays.
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Economie en transities: ongelijkheid, klimaat en globalisering
Analyse van maatschappelijke vraagstukken vanuit een economisch perspectief.
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3D modeling and RNA-based therapeutics for Dutch-type Cerebral amyloid angiopathy
Promotie
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and tissue dynamics with cell fate decisions through computational modeling
Promotie
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The LeiCNS-PK3.0 model development and applications: Healthy-to- diseased CNS pharmacokinetic translation
Promotie
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Innate immunity, developmental speed and their trade-offs in two hexapod models
Promotie
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Modelling the Interactions of Advanced Micro- and Nanoparticles with Novel Entities
Promotie
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Application of zebrafish and murine models in lipoprotein metabolism and atherosclerosis research
Promotie
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Learning-based Representations of High-dimensional CAE Models for Automotive Design Optimization
Promotie
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Computational modeling of pharmacokinetics and tumor dynamics to guide anti-cancer treatment
Promotie
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Model-Assisted Robust Optimization for Continuous Black-Box Problems
Promotie
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pathogenesis underlying bicuspid aortic valve disease using new disease models
Promotie
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Consortium DDMoRE lanceert open-access databank
Bio-farmaceuten kunnen vanaf nu modelcodes en datasets uit een databank opvragen om de dosering en het effect van nieuwe medicijnen beter te kunnen voorspellen.
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Onderzoek
Steden, Voedsel, Water, Biodiversiteit, Bronnen en Energie: dit zijn de belangrijkste onderzoeksthema’s voor het CML. Ons doel is altijd om wereldwijd voorop te lopen in ons vakgebied. En echte impact te hebben met onze onderzoeksprogramma’s.
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Towards artificial photosynthesis: resolving supramolecular packing of artificial antennae chromophores through a hybrid approach
Promotor: H.J.M. de Groot
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Medicijnafbraak bij kinderen: wat gebeurt er in de nieren?
Welke dosis geneesmiddel geef je een kind? Dat hang voor een groot deel van af van hoe snel hun nieren dit medicijn weer uit het bloed verwijderen. Om ethische redenen is het onmogelijk om dit bij jonge patiënten te meten. Promovenda Sinziana Cristea combineerde verschillende modelleermethodes en veel…
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"Het hele concept is gericht op activering van het onderwijs"
Elke student is bekend met de huidige vorm van hoorcolleges volgen. Je komt, je luistert en je gaat weer naar huis. Prof.dr. Frans-Willem Korsten introduceert het al bekende idee van 'Flipping the Classroom' nu aan onze faculteit, als een nieuwe vorm van onderwijs geven.
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Drie Leidse wetenschappers ontvangen NWO ENW-KLEIN subsidie voor vernieuwend onderzoek
De herkomst van Surinaamse rijst, een digitale tweeling van de aarde en een groot big-data project aan de Chileense hemel: drie Leidse wetenschappers ontvangen een ENW-KLEIN subsidie voor vernieuwend, fundamenteel onderzoek.
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Marlies Reinders
Integratie van MOOC in campus