1,260 zoekresultaten voor “human evolution” in de Publieke website
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Targeting Human Proteasomes: Substrates, Inhibitors and Prodrugs
Large parts of the research described in this Thesis aims at the development of oligopeptide-masked toxins and their in situ immunoproteasome-mediated activation.
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Voorlichtingsactiviteiten
Kom naar onze online en oncampus events om ons beter te leren kennen!
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Patiëntveiligheid; Human Factors. Jouw rol in het zorgteam
Ontdek de cursus Patiëntveiligheid van Boerhaave Nascholing en leer over Human Factor Management en veiligheid in de zorg. Lees hier meer!
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Human skin equivalents for atopic dermatitis: investigating the role of filaggrin in the skin barrier
Promotor: Prof.dr. J.A. Bouwstra, Co-promotor: A. El Ghalbzouri
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Development of human skin equivalents to unravel the impaired skin barrier in atopic dermatitis skin
Promotor: J.A. Bouwstra Co-promotor: A. El Ghalbzouri
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Ecology and conservation of spotted hyena in human dominated landscapes in northern Ethiopia
Promotors: Prof.dr. G.R. de Snoo, Prof.dr. H. Leirs (Univ. Antwerpen)
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Microengineered Human Blood Vessels For Next Generation Drug Discovery
Heart failure is a major health care problem with high mortality.
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Force sensing and transmission in human induced pluripotent stem-cell-derived pericytes
Pericytes, the mural cells of blood microvessels, are important regulators of vascular morphogenesis and function that have been postulated to mechanically control microvascular diameter through as yet unknown mechanisms.
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European and International Human Rights Law (Advanced LL.M.)
Leiden University’s Master of Law in European and International Human Rights Law (L.L.M.) looks at the various protection mechanisms applied to human rights across different political, social and cultural settings.
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Innovative strategies to clinically characterize the human tear proteome
Transplantation of labial salivary glands to the eyelids for patients with dry eye appears to give excellent results clinically.
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based toxicity assessment: towards quantitative risk prediction in humans
Promotor: Prof.dr. M. Danhof
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COMET. Human Subject Research and Medical Ethics in Colonial Southeast Asia
Investigating epistemic and ethical practices in medical experimentation on humans in the colonial period in Southeast Asia.
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Hard power and the European Convention on Human Rights
Op 18 juni 2019 verdedigde Peter Kempees zijn proefschrift 'Hard power and the European Convention on Human Rights'. Het promotieonderzoek is begeleid door promotoren prof. dr. R.A. Lawson en prof. dr. H. Duffy.
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Comparative ecology and genetics of sympatric wild cats in relation to human wildlife conflict in Bardia National Park, Nepal
What is the population size/structure and distribution of tiger and leopard inside the Bardia National Park (BNP) compared with the population outside? What is the movement and home range and conflict pattern in time and space of tigers and leopards inside the BNP compared with outside? What constitutes…
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Proving discriminatory violence at the European Court of Human Rights
Op dinsdag 23 mei 2017 verdedigde Jasmina Mackic haar proefschrift ‘Proving discriminatory violence at the European Court of Human Rights’. De promotor is vice-decaan en hoogleraar internationaal publiekrecht Larissa van den Herik. Hieronder volgt een korte samenvatting van haar proefschrift.
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Catecholamine function, brain state dynamics, and human cognition
Het onderzoek in dit proefschrift kijkt naar de rol van het locus ceuruleus - noradrenalinesysteem in verscheidene aspecten van menselijke cognitie, en de modulatie van de staat van het brein.
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Unraveling the Complexity of Human Oogenesis and Reproductive Tract Development
Promotie
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Parallel evolution in an invasive plant species: evolutionary changes in allocation to growth, defense, competitive ability and regrowth of invasive
Promotor: Prof.dr. P.G.L Klinkhamer, Co-promotor: K. Vrieling
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Human-lion conflict around Nairobi National Park: Lion Population Structure, Diet, and Movement in a Semi-Fenced Park.
What is the population size and social structure in time and space? What is the lion diet and food preference in time and space? What is the home range (MCP and Kernel) and movement in time and space? What are human – lion conflict and responses of lions to traditional herding in time and space? What…
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Pre-Neanderthalers beheersten complexe technieken
Een internationaal onderzoeksteam met Leidse archeologen heeft overtuigend bewijs geleverd dat pre-Neanderthalers 300.000 jaar geleden over een hoge mate van cognitieve complexiteit beschikten.
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The music of language: exploring grammar, prosody and rhythm perception in zebra finches and budgerigars
Promotor: C.J. ten Cate
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Ecology of the Ethiopian wolf in a changing landscape: Human carnivore interactions in Afroalpine ecosystems of Ethiopia
Do Ethiopian wolves change their diet and foraging strategy in the landscape under different land uses? How land use affect Afro-alpine rodent Communities? How important are Afro-alpine natural resources utilisation for local livelihoods? What is the human perception of conflict in the Afro-alpine a…
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publiceert boek Core Socio-Economic Rights and the European Court of Human Rights
Bij Cambridge University Press (CUP) verscheen onlangs van Ingrid Leijten het boek Core Socio-Economic Rights and the European Court of Human Rights. Het boek maakt onderdeel uit van de serie Cambridge Studies in European Law and Policy en heeft als onderwerp de bescherming van sociaaleconomische rechten…
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Conversation with Dr Graça Machel: intergenerational justice from a human rights perspective
Almost three years after receiving her honorary doctorate, Dr Graça Machel returned to Leiden University. Over the course of two days she spoke with students, researchers, and other interested persons, about human rights – particularly those of women and children – in a world in which these are continually…
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pharmacokinetic models to the prediction of local CNS drug concentrations in human
Clinical development of drugs for central nervous system (CNS) disorders has been particularly challenging and still suffers from high attrition rates.
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Fusing Electrical Stimulation and Wearable Robots with Humans to Restore and Enhance Mobility (Book Chapter)
Eduard Fosch-Villaronga, universitair hoofddocent bij eLaw, heeft bijgedragen aan 'Cyber–Physical–Human Systems', een boek waarin de nieuwste ontwikkelingen in interacties tussen cyberfysische systemen en mensen worden onderzocht.
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culture medium based approach to optimize the stratum corneum barrier of human skin equivalents
uman skin equivalents (HSEs) are in vitro 3D-skin models that mimic many aspects of the native human skin (NHS) and can be a valuable tool.
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Discovery and development of inhibitors selective for human constitutive proteasome and immunoproteasome active sites
This thesis describes the design and development of subunit‐selective inhibitors of particular catalytically active subunits of human constitutive proteasomes and immunoproteasomes.
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Transfer of "goods" from plants to humans: Fundamental and applied biochemical investigations on retaining glycosidases
The studies described in this thesis deal with glycosidases, in particular alpha-galactosidases.
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International courts in an era of smartphones and social media – improving human rights accountability?
Wat zijn de effecten van digitalisering op de internationale rechtspraak?
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creatIef, Creatiever, creaTiefst? Onderzoek naar het belang en de werking van creativiteitstraining bij Bachelor ICT-studenten
This dissertation presents the results of the importance of creativity for ICT-students of Dutch universities of applied sciences (in Dutch: hogescholen), and the functioning of training courses that aim to promote creative abilities is highlighted.
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Child Marriage as a Choice: Rethinking agency in international human rights
Op 18 maart 2020 verdedigde Hoko Horii haar proefschrift 'Child Marriage as a Choice: Rethinking agency in international human rights'. Het promotieonderzoek is begeleid door promotoren prof.dr. A.W. Bedner en prof.dr. G.A. van Klinken (UvA).
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Impact of land use changes on the human-elephant conflict
Promotor: G.R. de Snoo, W. Kustiawan, Co-promotor: H.H. de Iongh
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publicatie: Proving Discriminatory Violence at the European Court of Human Rights
Jasmina Mačkić, Universitair Docent Mensenrechten bij het Europa Instituut, heeft haar boek, Proving Discriminatory Violence at the European Court of Human Rights, gepubliceerd. Deze publicatie is gebaseerd op haar proefschrift die Mačkić in mei 2017 heeft verdedigd. Het onderzoek is mogelijk gemaakt…
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Essentiality of conserved amino acid residues in β-lactamase
Evolution acts via mutations in amino acid sequences. Substitution of essential amino acids leads to a nonfunctional protein. l.
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function of the dopaminergic midbrain - with a special focus on the human VTA
Promotie
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The International Legal Protection of Environmental Refugees. A human rights-based, security and State responsibility approach
Op 7 mei 2020 verdedigde Jolanda van der Vliet proefschrift 'The International Legal Protection of Environmental Refugees. A human rights-based, security and State responsibility approach'. Het promotieonderzoek is begeleid door promotoren prof.dr. N.J. Schrijver en prof.dr.ir. J.J.C. Voorhoeve.
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The Interactions of Human Mobility and Farming Systems and Impacts on Biodiversity and Soil Quality in the Western Highlands of Cameroon
Promotors: Prof.dr. G.R. de Snoo, Prof.dr. G.A. Persoon, Prof.dr.ir. H.H. de Iongh
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ecology of lion (Panthera leo Linnaeus 1975) populations and human-lion conflicts in Pendjari Biosphere Reserve, North Benin
Promotores: G.R. de Snoo, B. Sinsin, Co-Promotor: H.H. de Iongh
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models to uncover genes driving tumorigenesis and therapy resistance in human breast cancer
To improve cancer treatments, personalized medicine approaches have aimed to identify exactly which mutations are driving tumor development in a given patient and specifically target these mutations using precision therapies.
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Phylogenetic ecology of octocoral - gastropod associations
Promotor: E. Gittenberger, Co-promotores: L.P. van Ofwegen; B.W. Hoeksema
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North Sea noise in the Anthropocene: an impact study of human-made impulsive sounds on free-ranging cod
Sound is everywhere in the marine environment and hearing is therefore a very important for stimuli for fish. They use sound for orientation and communication, during migration, aggregation and spawning, but also for detection of prey and predators.
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role of animals in the epidemiology of antimicrobial resistance in humans
Promotie
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structure solution and crystallographic studies of the Sso10a2 and human C1 inhibitor protein
Promotor: Prof.dr. J.P. Abrahams, Co-Promotor: N.S. Pannu
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The role of water in hydrogen electrocatalysis
Promotor: M.T.M. Koper, Co-promotor: L. Juurlink
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A well-established harmony in chaos: from isolated galaxies to galaxy clusters
The origin and evolution of galaxies are closely linked to many different physical phenomena.
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Macrophages inhibit human osteosarcoma cell growth after activation with the bacterial cell wall derivative liposomal muramyl tripeptide in combination
CONCLUSION: This study demonstrates that human macrophages can be induced to exert direct anti-tumor activity against osteosarcoma cells. Our observation that the induction of macrophage anti-tumor activity by L-MTP-PE required IFN-gamma may be of relevance for the optimization of L-MTP-PE therapy in…
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Algorithm for Structural Variant Detection
Structural variants (SVs) are the hidden architecture of the human genome, and are critical for us to understand diseases, evolution, and so on.
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Ethiopian wolf (Canis simensis Rüppell 1835) in a changing landscape: Human carnivore interactions in Afroalpine ecosystems of Ethiopia
Ethiopian wolves are endangered diurnal Afroalpine rodent hunters. I investigated the interaction between wolves, rodents and human land use in Borena Sayint National Park (BSNP), Abune Yosef and Aboi Gara in Ethiopia.
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Evolutionary Developmental Biology of Bitterling Fish
We developed the bitterling as a unique, well-studied model organism in the area of the evolutionary ecology of brood parasitism. The bitterling-mussel relationship, interspecific mussel host preference, and mussel gill structure are studied in detail, to help understand the developmental adaptation…