416 zoekresultaten voor “global gene regulation” in de Publieke website
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Targeting for success: Mechanistic insights into microRNA-based gene therapy for Huntington disease
Promotie
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Afdeling Staats- en bestuursrecht goed vertegenwoordigd op Global Summit on Constitutionalism
Van 16 tot en met 18 maart vond de Global Summit on Constitutonalism plaats. Namens de Leidse afdeling Staats- en bestuursrecht zijn Wim Voermans, Gert Jan Geertjes en Rowie Stolk afgereisd naar Austin, waar de University of Texas at Austin, School of Law de conferentie organiseerde.
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Jean Monnet Chair of Moritz Jesse
Moritz Jesse has been awarded a Jean Monnet Chair by the European Commission. In his MIND-EU Project he will focus on a coherent way to teach Migration, Integration, and Non-Discrimination at Leiden Law School at bachelor and master level.
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Innate immunity, developmental speed and their trade-offs in two hexapod models
This thesis focuses on important life history traits and their trade-offs using two hexapod models. Particularly, the trade-off between immune defense and embryonic developmental speed is a central theme of this study.
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registratie: Minor Entrepreneurship for Society | Innovation, Co-Creation and Global Impact
Wacht niet tot je afgestudeerd bent, maak nu al impact! Ontdek je potentie om betekenisvolle ideeën te ontwikkelen met mondiale impact tijdens de minor Entrepreneurship for Society. Deze minor leert je hoe je je ideeën kunt verwezenlijken.
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Mechano-transduction mediated by integrin-based adhesion complexes: integration of cytoskeleton and adhesion dynamics
In this thesis, we focus on novel proteins/mechanisms that regulate integrin-adhesion mediated mechano-transduction.
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Vroege signalen voor een goede geestelijke gezondheid tijdens de adolescentie: Emotionele intelligentie is belangrijk
In een longitudinale studie onderzochten Adva Eichengreen en collega's hoe aspecten van emotionele intelligentie de ontwikkeling van de geestelijke gezondheid van adolescenten beïnvloeden. Zo identificeerden ze potentiële waarschuwingssignalen en doelen voor interventieprogramma's.
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Onderzoeksproject 'QUAD'
Onderzoeksproject 'QUAD'
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The first graduates of the Faculty of Governance and Global Affairs: LUC’s Class of 2015½!
LUC is the first to confer the diploma of the Faculty of Governance and Global Affairs, the new Faculty name since January 2016 making this graduation an extra special occasion.
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Rurale gemeenschappen in de civitas Cananefatium 50-300 na Christus
Deze dissertatie onderzoekt de rurale gemeenschappen van de Cananefaten in de periode van 50 tot 300 na Christus.
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Vriesendorp en prof. Wessels opgenomen in de 2020 Lawdragon Leading Global Restructuring & Insolvency Lijsten
Prof. Vriesendorp en prof. Wessels zijn opgenomen in de 2020 Lawdragon 500 Leading Global Restructuring & Insolvency Lawyers. Prof. Haentjens is genoemd in de 2020 Lawdragon Leading Global Restructuring Advisors & Consultants.
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Eurafrica: African perspectives, 1917-1970s
How did African actors engage with the idea of Eurafrica?
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Statistical methods for microarray data
Promotores: J.C. van Houwelingen, S.A. van de Geer
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Image-based phenotypic screening for breast cancer metastasis drug target discovery
The main aim of this thesis was to unravel the signaling and regulatory networks that drive tumor cell migration during breast cancer metastasis.
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Human skin equivalents for atopic dermatitis: investigating the role of filaggrin in the skin barrier
Promotor: Prof.dr. J.A. Bouwstra, Co-promotor: A. El Ghalbzouri
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Next generation bacitracin: reimagining a classic antibiotic
Given the accelerating appearance of antimicrobial resistance, there is an urgent need for more fundamental research into novel antibiotic strategies. The work in this thesis helps to address this global problem by developing new antibiotic compounds, inspired by the antibacterial mechanisms of the…
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Innovative strategies to clinically characterize the human tear proteome
Transplantation of labial salivary glands to the eyelids for patients with dry eye appears to give excellent results clinically.
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Uncovering vulnerabilities in triple-negative breast cancer
Triple-negative breast cancer (TNBC) constitutes a small subtype (~15%) of breast cancer, but causes the majority of breast cancer-related deaths.
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Modulation of leukocyte homeostasis in atherosclerosis
Promotores: Prof.dr. E.A.L. Biessen, Prof.dr. T.J.C. van Berkel
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Unraveling the mechanism of multicopper oxidases: from ensemble to single molecule
Promotores: Prof.dr. G.W. Canters, Prof.dr. T.J. Aartsma
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Carcinogenicity of insulin analogues
Promotor: Prof.dr. B. van de Water
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Role of integrin adhesions in cellular mechanotransduction
Promotor: B. vd Water, T. Schmidt, Co-Promotor: E.H.J. Danen
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Controlling growth and morphogenesis of the industrial enzyme producer Streptomyces lividans
Promotor: G.P. van Wezel, Co-Promotor: E. Vijgenboom
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Ecology and genomics of Actinobacteria and their specialised metabolism
Filamentous Actinobacteria, such as Streptomyces, produce a plethora of chemically diverse bioactive metabolites that have found applications across medicine, agriculture and biotechnology.
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Photocleavable activity-based acid glucosylceramidase probes
Lysosomal acid glucosylceramidase (GBA1) is a lysosomal enzyme that degrades glucolipids with its main substrate being glucosylceramide (GlcCer). Defects in the GBA1 gene lead to glycosphingolipidosis Gaucher disease (GD), in which the hydrolysis of GlcCer is impaired and therefore, it accumulates in…
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Mechanical and genetics basis of cellularization and serosal window closure in Tribolium castaneum
The applications of studying the early development of insects range from agriculture to material science.
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Algorithms for the description of molecular sequences
Promotor: J.N. Kok, P.E. Slagboom Co-promotor: J.F.J. Laros
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Toll-like receptor signaling in the innate immune system of zebrafish larvae
Promotor: H.P. Spaink, A.H. Meijer Co-promotor: R. Marin-Juez
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Disrupting the transcriptional machinery to combat triple-negative breast cancer
Triple-negative breast cancer (TNBC) is a subtype of breast cancer characterized by limited treatment options and unfavorable clinical outcomes. Therefore, the research described in this thesis focused on the exploration of novel targeted therapies for TNBC.
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Shepherding precision gene editing with CRISPR-Cas9 variants and adenoviral vectors
Promotie
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Role of metabolic pathways and sensors in regulation of dendritic cell- driven T cell responses
Promotie
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Publicatie Helen Duffy over Global Trends in Counter-terrorism and the Implications for human rights in Africa
Op 8 maart 2023 verscheen een monografie over Global Trends in Counter-terrorism and the Implications for human rights in Africa. Deze studie van Helen Duffy, hoogleraar Internationaal Humanitair Recht en Mensenrechten in Leiden, onderzoekt de impact van terrorismebestrijding op democratie, vrede, rechtsstaat…
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CRB1 gene therapy coming of age: Mechanistic insight and rAAV assays on mouse & human retinal organoid models
Promotie
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Meedoen met experimenten?
Wil je deelnemen aan ons onderzoek in Psychologielab op Wielen? Momenteel hebben we twee experimenten in de bus. Natuurlijk zorgen we voor de bescherming van je gegevens en privacy. Doe mee met onze experimenten en meld je aan.
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Images of Galois representations
Promotores: S.J. Edixhoven, P.Parent
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Breaking the witches' spell: towards steering the soil microbiome for volatile-mediated control of the root parasitic weed Striga
Striga hermonthica, commonly known as witchweed, infests major cereal crops in Sub-Saharan Africa causing severe yield losses and threatening the livelihood of millions of resource poor farmers.
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Finding Nemo: Locating Financial Losses after Kolassa/Barclays Bank and Profit
Over het lokaliseren van vermogensschade en de geldigheid van forumkeuzes in het licht van de recente uitspraken Kolassa/Barclays Bank en Profit van het Hof van Justitie van de Europese Unie.
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Chemical Similarity: Structuring Risk and Hazard Assessment
At the moment, over 350.000 chemicals are registered worldwide for production and use. Their application, however, may harm human health and the environment.
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Empirical Legal Studies Leiden
Empirical Legal Studies in Leiden focust op het bouwen van een interdisciplinaire gemeenschap van rechtsgeleerden en sociale wetenschappers die samen juridische vraagstukken onderzoeken op het snijpunt van recht en gedrag, waarbij diverse soorten methoden worden gebruikt.
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Liability of football clubs for supporters’ misconduct
Op 19 mei 2016 verdedigt Rosmarijn van Kleef haar proefschrift getiteld: Liability of football clubs for supporters’ misconduct. A study into the interaction between disciplinary regulations of sports organisations and civil law'.
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Insights into microtubule catastrophes: the effect of end-binding proteins and force
For each living organism health is ensured by correct functioning of its cells. Cells therefore have elaborate methods for regulation of their proteins.
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The impact of climate variability on the ecology of a lion (Panthera leo Linnaeus 1758) population and lion livestock conflicts in the Amboseli
Promotor: Prof.dr. G.R. de Snoo, Prof.dr. G.A. Persoon, Co-promotor: H.H. de Iongh
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Andere publicaties
Andere COI-publicaties zijn te vinden op Leiden Law Blog, de Leiden Law Methods Portal en in het drop-down-menu hieronder.
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Unraveling the auxin mechanism in 2,4-D induced somatic embryogenesis in Arabidopsis thaliana
Promotor: P. J. J. Hooykaas, Co-promotor: R. Offringa
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Metabolomic characteristics of Catharanthus roseus plants in time and space
Promotor: R. Verpoorte, Co-promotores: Y.H.Choi, N.R. Mustafa
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Cross-border Claims to Cultural Objects
Op 11 november 2021 verdedigde Evelien Campfens het proefschrift 'Cross-border Claims to Cultural Objects'. Het promotieonderzoek is begeleid door prof.dr. N.J. Schrijver en prof.dr. W.J. Veraart (VU Amsterdam).
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Overige masters
Bij eLaw verzorgen we een aantal vakken voor de master Jeugdrecht en voor de master International Children's Rights (Advanced LL.M.)
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Collateral Transactions and Shadow Banking
Op 13 oktober 2021 verdedigde Ross Spence het proefschrift 'Collateral Transactions and Shadow Banking'. Het promotieonderzoek is begeleid door promotoren prof.mr. M. Haentjens en prof.dr. A.M. Pacces (UvA).
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Matter into context: population- and community-level impacts of nanomaterials in freshwater ecosystems
The application of nanomaterials in industrial processes and consumer products provides many societal benefits, but can also lead to the release of nanomaterials into the environment. The work in this dissertation aims to provide insights into the potential environmental impacts that may follow from…
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Zebrafish as vertebrate model of Gaucher disease
Lysosomal storage disorders (LSDs) are a group of orphan diseases characterized by lysosomal dysfunction or impaired lysosomal catabolism and affect collectively about 1 in 5000 live births.