Promotor: P.G.L. Klinkhamer, Co-Promotores: K. Vrieling, P.P.J. Mulder

Acute cardiovascular syndromes, including myocardial infarction or stroke, are the principal cause of death in the Western society. The main underlying pathology of cardiovascular diseases is atherosclerosis, which is caused by the accumulation of lipids and inflammatory cells in the vessel wall, in…

Sewer pipes are an essential infrastructure in modern society and their proper operation is important for public health. To keep sewer pipes operational as much as possible, periodical inspections for defects are performed.

This thesis studies the geometry of representation varieties and character stacks. These are spaces parametrizing the representations of a finitely generated group, typically the fundamental group of a compact manifold, into an algebraic group G.

The department of Industrial Ecology is dealing with research into the development of tools for decision making on sustainable production and consumption.

This thesis presents pioneering work on the panchromatic emission of some of the most luminous galaxies in the early Universe: star forming galaxies and active galactic nuclei.

We strive to address the challenge of constructing a modeling language to write software which can take advantage of recent hardware developments (multicore, cloud) without compromising in its abstraction levels.

Promotor: Prof.dr. G.R. de Snoo, Co-promotor: R. Heijungs

The effective treatment of tuberculosis (TB) remains a major challenge to global health.

This thesis investigates how quantum, quantum-inspired, and hybrid quantum-classical computation can enhance key points of the automated machine learning (AutoML) pipeline under the constraints of noisy intermediate-scale quantum (NISQ) devices.

Increasing the efficiency of gene targeting (GT) as a genome editing tool in plants has been an important goal in plant biotechnology.

Humans can see the world through the eyes of other humans and imagine what they know, want, and intend. This competence is known as Theory of Mind.

Promotor: Prof.dr. M. Danhof, Co-Promotor: J. de Jongh

De Faculteit Geesteswetenschappen publiceert jaarlijks een D&I kalender. Deze kalender dient als instrument om bewustzijn en begrip te creëren voor belangrijke religieuze feestdagen en andere vieringen van de diverse groepen binnen onze academische gemeenschap.

Vitamin A or retinol is essential in embryonic development, the visual cycle and the immune system.

In this thesis unconventional tools based on fluidic interfaces were developed to study the surface and interfacial chemistry of graphene, to characterize the intrinsic properties of graphene, to disentangle the effects of substrate and of the environmental factors, and to improve handling protocols…

We consider the propagation of electrical signals through nerve fibres.

Business Process Model and Notation (BPMN) has become the standard for business processes diagrams.

Lysosomal glycosidases are acid hydrolases that fragment glycoconjugates in lysosomes.

Op maandag 19 mei 2025 organiseert Website Application Services van het ISSC in samenwerking met SC&M een Webinar Universitaire Website[s]. Tijdens dit online web event wordt je o.a. ge-update over diverse inhoudelijke zaken die voor jou als webredacteur belangrijk kunnen zijn! Ga via deze link…

Promotor: H.P. Spaink, A.H. Meijer Co-promotor: R. Marin-Juez

Virtual Reality is een computertechniek waarbij het lijkt alsof je in een andere werkelijkheid bent. Als je een speciale VR-bril op zet, bevind je je in een virtuele omgeving. Net zoals in een game. Als je je hoofd beweegt, kijk je rond in de virtuele omgeving, waardoor je het gevoel hebt dat je écht…

Anticipatie op de uitdagingen en voordelen die AI-ondersteunde beoordelingen met zich meebrengen voor de relatie tussen studenten en docenten, de menselijke, evenals sociaal-economische kosten en kansen die zij voor universiteiten creëren.

Promotor: S.M. Verduyn Lunel

PNEC-pro is a user-friendly screening tool for professionals dealing with the assessment of surface water quality. The tool calculates local, watertype specific no-effect concentrations (PNEC) of copper, lead, nickel and zinc based on biotic ligand models (BLMs).

Immunotherapies for cancer are an emerging class of therapeutic strategies which aim to treat cancer via augmentation of the immune system.

Promotor: J.A. Bouwstra Co-promotor: A. El Ghalbzouri

Taking as a point of departure the Italian American community in Boston and its process of collective remembrance surrounding Saint Anthony’s Feast, we addressing the limits and potential of montage.

In this work, we illustrate unconventional approaches towards the fabrication of edge functionalized graphene nanostructures and bidimensional architectures in polymeric and metallic supports, with an outlook towards molecular sensing devices.

Promotores: A.H. Meijer, H.P. Spaink

Marine sponges are important members of reef ecosystems, as they play ecological roles that are essential for the health of the reef.

Glycoside hydrolases (glycosidases/GHs) are widely abundant enzymes in all kingdoms of life and are important biocatalysts that catalyze the hydrolysis of glycosidic linkages in oligo/polysaccharides, glycoproteins and glycolipids with tremendous efficiency

This thesis describes the use of bioorthogonal proteins in immunological settings. It provides an introduction towards the field of protein modification, which was used throughout the thesis for the expression of proteins containing unnatural amino acids.

Promotor: B.van de Water, Co-promotor: L.S.Price

This dissertation focuses on developing new mathematical and statistical methods to properly represent time-varying covariates and model them within the context of time-to-event analysis.

With increasing carbon dioxide levels in the atmosphere and their detrimental effect on the global climate, modern society needs to push for more renewable energy sources. Storing widely accessible and abundant solar energy in chemical bonds in the form of molecular fuel via artificial photosynthesis…

Promotoren: Prof.dr. G.R. de Snoo en Dr. R. Heijungs

Promotor: Prof.dr. A. Achucarro

De LUMC Alumni Vereniging is in 1996 opgericht om enerzijds de band tussen het Leids Universitair Medisch Centrum en zijn alumni te versterken, anderzijds om de band van de alumni onderling te versterken.

Producing green energy has become the main goal in our society in the search of reducing or eliminating the carbon emission from fossil fuels.

This thesis explores how electron paramagnetic resonance (EPR) spectroscopy can be used to investigate key biochemical processes.

Schistosomiasis is an acute and chronic disease caused by blood dwelling parasitic trematodes of the genus Schistosoma, and it is classified as the second most socioeconomically devastating parasitic disease, second only to malaria.

Promotor: Prof.dr. J.P. Abrahams, Prof.dr. M. van Heel

De Leergang Public Affairs biedt een sterke basis voor professionals in de overheid, het bedrijfsleven of maatschappelijke organisaties die actief zijn in het beïnvloeden van besluitvorming en beleid.

This thesis explores how bees and hoverflies are distributed across the Dutch landscape and how ecological and landscape factors shape their occurrence.

Op maandag 19 mei 2025 organiseert Website Application Services van het ISSC in samenwerking met SC&M een Webinar Universitaire Website[s]. Tijdens dit online web event wordt je o.a. ge-update over diverse inhoudelijke zaken die voor jou als webredacteur belangrijk kunnen zijn! Ga via deze link…

Afgestudeerden van de masterspecialisatie Onderwijs en Opvoeding in een Digitale Wereld aan de Universiteit Leiden zijn goed voorbereid op uiteenlopende functies. Zij kunnen bijvoorbeeld kindertherapeuten adviseren over e-healthtoepassingen, scholen begeleiden bij het gebruik van digitale middelen en…

The main aim of this thesis was to unravel the signaling and regulatory networks that drive tumor cell migration during breast cancer metastasis.

Animal diet studies are critical for understanding ecological processes such as trophic interactions, energy flow, and nutrient cycling. By examining what animals consume, ecologists gain insights into species specialization, predator-prey relationships, and ecosystem management.