The cellular metabolism of immune cells constitutes an important part of their proper function and activation. Using T cells as an example, this phenomenon is highlighted by the metabolic reprogramming that occurs in these cells upon activation.

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Pericytes, the mural cells of blood microvessels, are important regulators of vascular morphogenesis and function that have been postulated to mechanically control microvascular diameter through as yet unknown mechanisms.

Promotor: A.P.IJzerman Co-promotor: A. Bender

How do you engage society to stop biodiversity loss? How do you create political and social involvement to deal with climate change? And how do you balance the economic needs of industry with the negative effects of pollution? If you find these kinds of questions interesting, then this Pre-University…

Op vrijdag 24 maart gaf prof: Amanda Perry-Kessaris (Kent Law School) een korte workshop over data visualisation voor de promovendi van de afdeling Economie. Tijdens deze workshop werden de promovendi uitgedaagd om door middel van LEGO hun onderzoek te visualiseren. Amanda Perry-Kessaris gaf daarna…

Early time-resolved experiments by Frauenfelder on the ensemble of the kinetic rebinding of CO to myoglobin molecules resulted in a stretched exponential relaxa-tion due to a very large spread of the reaction rates of individual molecules.

Promotor: Prof.dr. J.W.M. Frenken

Climate change is one of the largest challenges faced by humanity. To combat this research into alternatives to fossil fuels is ongoing. Dihydrogen is considered a good alternative fuel, since its burning only forms water.

The dissertation offers new tools and insights to computation and modelling of topological phases, with an emphasis on the aperiodic setting.

Planets are formed in disks of gas and dust around young stars.

Promotores: S.F. Portegies Zwart, E. M. Rossi

In deep reinforcement learning, searching and learning techniques are two important components. They can be used independently and in combination to deal with different problems in AI, and have achieved impressive results in game playing and robotics. These results have inspired research into artificial…

Promotores: Prof. dr. G.R. (Geert) de Snoo, Dr. E. (Ester) van der Voet

Op 21 oktober 2021 verdedigde Frederik Behre het proefschrift 'A European Ministry of Finance?'. Het promotieonderzoek is begeleid door promotor prof.dr. S.C.G. Van den Bogaert.

Promotor: M. Danhof, Co-promotor: E.C.M. de Lange

Het recht van de Europese Unie beïnvloedt direct en indirect de reikwijdte van strafrechtelijke aansprakelijkheid in Nederland. Die beïnvloeding heeft betekenis voor het materieelrechtelijk legaliteitsbeginsel.

This thesis describes the development and optimization of the first molecular tools to study the enzyme PLA2G4E.

This thesis seeks to investigate how cancer-associated mutations affect the pharmacological properties of selected GPCRs—primarily A2AAR and 5-HT2CR—through a combination of ligand binding assays, signaling readouts, kinetic profiling, and cellular functional assays.

A century ago, it was unclear whether the stars in the sky were clustered in groups, or widely spread in the universe.

Leiden Institute of Advanced Computer Science (LIACS)

The overarching clinical aim of this thesis was to improve pharmacological pain management by characterizing the pharmacodynamics of analgesics. This promotion has been awarded the predicate cum laude.

A single self-assembled semiconductor quantum dot in a high-finesse optical microcavity - the subject of this thesis - is an interesting quantum-mechanical system for future quantum applications. For instance, this system allows trapping of an extra electron and thus can serve as a spin quantum memory,…

Promotor: A.P. IJzerman

Promotores: A.P. IJzerman, H.W.T. van Vlijmen

Metastasis is responsible for over 90% of cancer-related deaths and arises from the ability of a small subset of tumor cells to detach from the primary tumor, overcome multiple biochemical and mechanical barriers, disseminate through the body, and colonize distant organs.

Promotor: Prof.dr. A.P. IJzerman, Co-Promotor: L.H. Heitman

The zoo of detected exoplanets reveals both the uniqueness of our own Solar System and the complexity of planetary system formation, sparking fundamental questions about how planetary systems form and evolve.

Promotie

Promotores: Prof.dr. F.S. de Boer, Prof.dr. J.J.M.M. Rutten (Radboud Universiteit Nijmegen)

Dit academisch jaar zal de Leiden Socio-Legal Series (LSLS) van start gaan! In deze reeks van 10 lezingen zal maandelijks een jurist(e) aan de hand van zijn of haar eigen onderzoek aangeven op welke wijze het rechtssociologisch perspectief – in theoretische en/of methodologische zin – daarbij een rol…

In this thesis, we describe the latest advances in SQUID-detected Magnetic Resonance Force Microscopy (MRFM).

Triple-negative breast cancer (TNBC) constitutes a small subtype (~15%) of breast cancer, but causes the majority of breast cancer-related deaths.

De astronomie begon met het bestuderen van het licht van de sterren. Deze sterren worden geboren in uitgestrekte wolken van gas en stof.

Quantummechanica voor iedereen

Mechanical metamaterials are man-made materials which derive their unusual properties from their structure rather than their composition.

For many centuries, news about catastrophic events has been disseminated via media such as pamphlets, chronicles, poems, and prints. This conference welcomes contributions that engage with the cultural dimensions of disasters and reflect on representations of catastrophes in different media.

De onderzoeksgroep Digital Archaeology beheert twee computerlaboratoria voor verschillende doeleinden: een onderwijslab en een onderzoekslab.

De onderzoeksgroep Terrorism and Political Violence van de Universiteit Leiden bestudeert de oorzaken van radicalisering, de tactieken van extremistische groeperingen, en de effectiviteit van anti-terrorismebeleid. We onderzoeken ook de rol van media en de invloed van postkoloniale erfenissen in de…

The LIACS Media Lab has received a research grant from the worldwide leading graphics hardware company NVIDIA. The grant exists of newly developed hardware utilizing thousands of processors. LIACS researchers will use it to investigate deep learning in understanding imagery from sources such as MRI…

ILS organizes a new lunch seminar series where all researchers from Leiden Law School can present their research. The idea is to hear in a simple and nice way what researchers from other research programs and institutes are working on. During a seminar two or three speakers will present their research.…

Leids rechtshistorisch onderwijs

"To see, to hear, to touch, to kiss, and so on: Dealing with charters in the early Middle Ages." Guest lecture by Prof. Dr. Philippe Depreux (University of Hamburg): Tuesday 9 May 2023, 15.00-16.30

Subproject of the ERC project 'Challenging the Liberal World Order from Within: The Invisible History of the United Nations and the Global South'.

One of the effects of climate change is the phenomenon of desertification, a process that occurs in semi-arid and arid areas and causes land degradation as well as vegetation loss. Due to the lack of resources, vegetation self-organizes to sustain itself by forming large-scale spatial patterns.

The type-IV secretion system (T4SS) is a machinery able to transfer DNA and proteins between bacteria and in certain cases also to eukaryotic cells.

This thesis is a collection of experimental attempts to enhance photoluminescence of fluorescent molecules and quantum dots with single gold nanorods (GNRs) and relevant applications.