Promotores: W.T. de Groot, M. Tchuenté, Co-promotor: J.P. Cheylan

Op NOS.nl het artikel 'Weer nieuwe stakingsdag Parijs, veel Fransen verzetten zich nog tegen pensioen bij 64'.

Promotor: Prof.dr. M. Danhof

Promotores: Prof.dr. E.A.L. Biessen, Prof.dr. T.J.C. van Berkel

We developed the bitterling as a unique, well-studied model organism in the area of the evolutionary ecology of brood parasitism. The bitterling-mussel relationship, interspecific mussel host preference, and mussel gill structure are studied in detail, to help understand the developmental adaptation…

In this thesis, we aimed to better understand the underlying mechanisms involved in TNBC progression and metastasis formation and discover new targets to reduce breast cancer related deaths.

This thesis explores different avenues to develop insurmountable antagonists for CC Chemokine Receptors, such as CCR1, CCR2 and CCR5.

The CC chemokine receptor 2 (CCR2), a member of the G protein-coupled receptor (GPCR) superfamily, is widely involved in autoimmune and inflammatory diseases. However, no drugs for this receptor have made it to the pharmaceutical market yet.

Promotores: Prof.dr. G.F.A. Kersten, W. Jiskoot, Co-promotor: J-P. Amorij

In the current global context, there is a pressing need to address sustainable energy supplies to safeguard our Planet and its ecosystems. The choices made by human society have a significant impact on genetic evolution and climate.

Sorghum (Sorghum bicolor) is a major cereal crop that millions of subsistence farmers in Sub-Saharan Africa (SSA) rely on. However, the scourging impact of the root parasitic weed Striga (Striga hermonthica, a.k.a. “witch-weed”) has remained a major constraint hampering the productivity of sorghum in…

Promotor: Prof.dr. R. Verpoorte, Co-Promotor: Dr. Young Hae Choi

Solute carrier (SLC) transporters are a large and diverse class of relatively understudied transmembrane proteins.

The following report discusses a survey on the topic of the Sustainable Development Goals that was distributed among researchers at Leiden University in the month of November 2021.

The function of TLRs in innate immunity has aroused worldwide attention soon after its discovery. Because of the broad functions of TLR2 in innate immunity, the drive for the development of TLR2-targeted vaccines or therapeutic treatments has accelerated in the last decades.

Drug development is a time- and resource-consuming process that starts with the discovery and validation of a (protein) target that contributes to pathogenesis or disease progression.

“Temminck’s Order” is the scientific biography of Coenraad Jacob Temminck (1778–1850), a Dutch naturalist and the first director of ’s Rijks Museum van Natuurlijke Historie in Leiden.

Chemical-induced organ toxicity is a major concern in the development and use of chemicals, including drugs, pesticides, industrial chemicals and cosmetics. In the last decades, the onset and progression of chemical-induced organ toxicity has been linked amongst others to perturbation of mitochondri…

There is an urgent need for more physiologically relevant cell culture methods to guide compound selection in pre-clinical stages of the drug development pipeline.

This thesis describes the functional analysis of the Arabidopsis AHL15 gene.

This PhD-thesis presents a study on micron-sized particles, so-called colloids. By controlling the chemical and physical properties of these particles, such as the interparticle interaction and the particles’ shape, colloids can act as building blocks that self-assembly into larger structures.

Optimization tasks in practice have multifaceted challenges as they are often black box, subject to multiple equality and inequality constraints and expensive to evaluate.

Antibiotic resistance, caused by widespread use of antibiotics, leads to bacterial infections that are difficult, if not impossible, to treat and is a major worldwide health concern.

In this Ph.D. thesis, we characterized two novel upstream regulators of JUB1, HB40, and HB22, in Arabidopsis thaliana. In Chapter 2, we described functions of HB40 in modulating growth and development via the regulation of JUB1 and GA inactivation genes GA2OXs.

This thesis describes the development of improved formulations and alternative delivery strategies for polio vaccination.

De programmagroep Leer- en Gedragsproblemen in het Onderwijs is verantwoordelijk voor onderwijs op het gebied van leerproblemen binnen de bachelor- en masteropleidingen van het Instituut Pedagogische Wetenschappen.

Glycosidases (GHs) are enzymes responsible for the degradation of carbohydrates and play many roles in human health and pathophysiology. Often, abnormal levels of glycosidase activity are markedly linked to human pathologies.

The main subject of this thesis is the design and synthesis of paramagnetic molecules for protein studies with NMR and EPR spectroscopy.

Drug-induced liver injury (DILI) is one of the main reasons for drug attrition during pre-clinical and clinical phases of drug development as well as for drug withdrawal post-marketing.

The adenosine receptors are proteins that reside in the extracellular membranes of cells. Activation of adenosine receptors plays a role in many physiological and pathological processes, such as immune responses and cancers.

This thesis addresses the challenge of sustainable urban development by analyzing the interplay between green and grey infrastructure to optimize resource use and ecosystem services.

The way organisms develop from the initial single-cellular state to a complex final assembly like the human body, and how the final body is maintained throughout life, is one of the greatest mysteries and it’s understanding one of the biggest scientific challenges.

Jiska Peper bemant de vraag-maar-raak-balie op de Klokhuisvragendag in Nemo op 25 juni. Neeltje Blankenstein en Lara Wierenga vertellen aan een zaal vol kinderen wat er gebeurt in je brein als je verliefd bent. ‘Vingers omhoog! Wie is er hier verliefd?’

Het Leiden Institute for Advanced Computer Science is vanaf januari 2019 onderdeel van het RISE_SMA project. Bij dit Europese project zullen 6 universiteiten zich samen met bedrijven, overheden en NGO’s inzetten om inzicht te krijgen in social media data tijdens crisissituaties. De kick-offmeeting vond…

Zelden trokken bevolkingsgroepen zich zo sterk terug in hun eigen bubbel als nu. Rechtssocioloog Maartje van der Woude gaat met haar studenten onderzoeken wat social distancing doet met de onderlinge verhoudingen. Hoe kijken Leidenaren in coronatijd bijvoorbeeld aan tegen studenten en inwoners met een…

Migration and Mobility in the Early Roman Empire by Luuk de Ligt and Laurens E. Tacoma (Eds.)

Van alle medewerkers van Universiteit Leiden werd 15,8% vorig jaar onheus bejegend. Dit blijkt uit de Personeelsmonitor 2021. ‘Dat is te veel. Het taboe moet af van bespreken en aanspreken’, zegt Martijn Ridderbos, lid van het college van bestuur, in een openhartig gesprek, samen met wetenschapper Helen…

Peter Bos, universitair hoofddocent aan het Instituut Pedagogische Wetenschappen, ontvangt de J.J. Groen Prijs (30.000 euro) voor zijn onderzoek naar de vraag waarom sommige mensen uit zichzelf zorgzaam en empathisch zijn en anderen juist niet. De bevindingen van zijn onderzoek hebben grote potentie…

De masterspecialisatie Sociology of Policy in Practice biedt de mogelijkheid om een onderzoeksstage te doen om het beleid van een bedrijf of organisatie in de praktijk te bestuderen..

The Minor Computational Approaches to Disease, Signaling and Drug Targets (CADSDT) is focused on fundamental scientific research required for discovery of new drug targets and development of new drugs.

In de masterspecialisatie Visual Ethnography leer je de kneepjes van het vak om etnografisch onderzoek met audiovisuele methodes te doen.

Politicoloog Rebekah Tromble (Universiteit Leiden) en sociolinguist Dirk Hovy (Universiteit van Copenhagen) analyseren hoeveel vijandigheid en sexisme Clinton heeft te verduren op Twitter en waar de aanvallen op haar persoon vandaan komen.

De eer was aan Professor Simon Portegies Zwart en doctor Jeroen Bédorf om voor het blad IEEE Software te schrijven.

Overheden investeren enorme bedragen in hun digitale dienstverlening. Het doel van effectiviteit en efficiency wordt echter niet voor alle mensen gehaald.