Striga hermonthica, commonly known as witchweed, infests major cereal crops in Sub-Saharan Africa causing severe yield losses and threatening the livelihood of millions of resource poor farmers.

This ecological community has long been known to affect host biology, and their diverse roles have been further clarified in recent years following numerous studies of animal:microbiota interactions in diverse systems.

Trigonostemon Blume is a plant genus in the family Euphorbiaceae comprising 59 species.

Taxonomy as a science has accumulated data and knowledge for more than 250 years.

Promotor: J.M. van den Broek Co-promotor: M.C. de Vries

Promotor: Jan van der Greef; Co-promotors: Mei Wang; Eduard van Wijk

The effects of anthropogenic noise on interactions between predators and their prey are still little understood.

NNMT wordt beschouwd als een nieuw potentieel farmacologisch doelwit in de behandeling van een verscheidenheid van kankers, stofwisselingsziekten en andere pathologieën. Het toenemend aantal publicaties waarin de rol van NNMT bij ziekten wordt opgehelderd, heeft op zijn beurt de ontwikkeling van krachtige…

Kom meer te weten over de opleiding Bio-Farmaceutische Wetenschappen. Het programma, de inschrijving en je toekomst.

Het Natuurwetenschappelijk Gezelschap Leiden (NGL) is een vereniging voor geïnteresseerden in natuurwetenschappelijke en medische onderwerpen die in een gemoedelijke sfeer kennis met elkaar willen opdoen, gepaard met levendige discussies.

Anthropogenic noise has been shown to affect marine animals in various ways, this may have fitness consequences at individual and population level. This thesis aims to increase insight into the quantification of sound-induced behavioural responses that are relevant to fitness, and into factors that…

Fungal food spoilage often starts with a contamination with spores. Experimental data strongly indicate the existence of subpopulations of spores with different levels of resistance to preservation methods.

Promotor: Prof.dr. J. den Hertog

This thesis focuses on important life history traits and their trade-offs using two hexapod models. Particularly, the trade-off between immune defense and embryonic developmental speed is a central theme of this study.

The plant hormone auxin plays a central role in the growth and development of plants. Auxin acts in a concentration dependent manner and polar cell-to-cell transport of this hormone determines its distribution in the tissues of plants. This polar auxin transport is mediated by several families of auxin…

Natural vanilla flavor is one of the most important in the world. However, the cost of this flavor is expensive. Production of this flavor by alternative methods, could reduce the cost.

The PID-directed shift in PIN polarity has been broadly accepted as one of the essential mechanisms for the regulation of auxin transport polarity.

This research delves into the unique cultural approach of the Tenggerese people, an Indigenous community in East Java, Indonesia, regarding elderly care. It focuses on their traditional practices of bakti (‘filial piety’) and sayan (‘mutual aid’), deeply ingrained in the community's lifestyle and va…

Autophagy is a fundamental degradative process, maintaining cellular homeostasis and functions in host defense against intracellular pathogens, including mycobacteria and Salmonella.

Salicylic acid (SA) is a plant hormone, which is involved in the defense responses to pathogens and to abiotic stress, and in the regulation of plant growth and development.

Acidobacteria is a widely distributed phylum but their functional roles in ecosystem processes are still largely elusive.

Promotores: A.H. Meijer, H.P. Spaink

Plants and soils from natural ecosystems harbor great diversity of soil microorganisms, which could potentially contribute to the sustainability of horticulture. The knowledge about using wild plant species and soil from natural ecosystem to improve the crop health will advance the application of ecological…

Promotor: E.F. Smets Co-promotor: J. Geml

Met de krachtige elektronenmicroscopen van NeCEN bestuderen we afwijkingen aan cellen van bloedvaten bij hart- en vaatziekten, de wisselwerking tussen ziekteverwekkers en gastheren bij infectieziekten, moleculaire processen die kanker veroorzaken, de interactie tussen geneesmiddelen en target-eiwitten.…

Glucocorticoids are potent anti-inflammatory drugs widely used clinically to treat various inflammatory and immune conditions. However, two main clinical problems limit their use. GCs trigger severe side effects and they induce acquired glucocorticoid resistance, especially during chronic systemic treatment…

Understanding DNA repair mechanisms is essential for advancing plant biotechnology and crop improvement. This study investigates how double-strand breaks (DSBs), induced by CRISPR/Cas systems, are repaired in the model plant Arabidopsis thaliana, and how these processes influence Agrobacterium tumefaciens…

The work described in this dissertation contributes to a better mechanistic understanding of nanoparticles in vivo. To achieve that goal, we used the zebrafish as a highly predictive pre-screening model of nanoparticles.

Promotores: H.A. Udo De Haes, P.M. Brakefield

Promotor: Prof.dr. M.K. Richardson

We developed the bitterling as a unique, well-studied model organism in the area of the evolutionary ecology of brood parasitism. The bitterling-mussel relationship, interspecific mussel host preference, and mussel gill structure are studied in detail, to help understand the developmental adaptation…

Het practicum en de lessenserie sluiten aan bij verschillende thema’s in de lesmethode.

Transplantation of labial salivary glands to the eyelids for patients with dry eye appears to give excellent results clinically.

The plant hormone auxin regulates plant growth and development through polar cell-to-cell transport-generated maxima and minima. PIN FORMED (PIN) auxin efflux carriers determine the direction of this auxin flow through their asymmetric placement on the plasma membrane (PM).

The bacterial cell wall is a nearly universal structure that offers protection and gives the cell its shape. However, environmental stressors, such as cell wall-targeting antibiotics and hyperosmotic conditions, can induce bacteria to shift to a wall-deficient state. It is unknown whether the lack of…

Streptomyces are multicellular, Gram-positive bacteria in the phylum of actinobacteria which produce a high amount of bioactive natural products of which the expression is tightly coordinated with the life cycle.

Bacteria have the ability to alter their morphology in order to adapt to changing environments.

Plant exudates appeared long time ago in the history line of life in the early Devonian. They are typical saps produced by specialized cells.

Promotor: P.J.J. Hooykaas, Co-Promotores: P.B.F. Ouwerkerk, M. Wang

Vancomycin is a last-resort antibiotic for the treatment of many Gram-positive bacterial infections, while remaining inactive against Gram-negative strains.

Promotor: R. Verpoorte, Co-promotores: Y.H.Choi, N.R. Mustafa

By growing in a soil plants change the biotic and abiotic properties of the soil in which they grow.

Een deel van de stalen constructie van de voormalige Gorlaeus Hoogbouw van de Faculteit Wiskunde en Natuurwetenschappen is de basis geworden van een nieuwe groene fietsenstalling.

The applications of studying the early development of insects range from agriculture to material science.

Promotor: P. J. J. Hooykaas, Co-promotor: R. Offringa

Promotors: Prof.dr. P.J. Punt, Prof.dr. C.A.M.J.J. van den Hondel

The haplolepideous mosses (Dicranidae) comprise about 4000 species distributed over a wide range of habitats, with great gametophytic and sporophytic morphological variation. Their monophyly is well supported by the results of several molecular phylogenetic studies, which shed light on their relationships…

Plant-microbe interaction resulted in different physio/chemical responses by host plant and interacting rhizobacteria.