Biodiversity enables ecosystems to thrive through the synergy of functional differences among organisms. While human well-being strongly depends on biodiversity-driven ecosystem services, human actions are also at the root of current unprecedented biodiversity declines.

Verbeteren van pandemische paraatheid via een gezamenlijk privacy-by-design datamodelleringsplatform.

Human vocal communication and music perception represent advanced cognitive skills, seemingly innate and universal. These faculties encompass a range of perceptual and cognitive abilities. Cross-species research sheds light on the origins of musicality by investigating whether these traits are shared…

Promotor: A. Doelman, Co-promotores: P.J.A. van Heijster; A. Zagaris

Promotor: Prof.dr. H.V.J. Linnartz

Like a mixture of oil and water, lipid membranes separate into two liquid phases.

The main aim of my Ph.D. thesis is to further explore the value of using early developing zebrafish larvae (up to 5 dpf) as a model to study anxiety-like behaviour and their pharmacological modulation with drugs.

In this thesis, two potential therapeutic targets for diabetic nephropathy were dentified and investigated. First, we show that glomerular clusterin is upregulated in diabetic nephropathy and demonstrated that recombinant clusterin protein can protect the podocytes against oxidative stress in vitro.…

This thesis mainly focuses on multimodal understanding and Visual Question Answering (VQA) via deep learning methods. For technical contributions, this thesis first focuses on improving multimodal fusion schemes via multi-stage vision-language interactions.

The aim of this thesis is to develop and study a robust and adaptable scaffold for supramolecular polymer self-assembly in water.

This dissertation contains four works during my PhD. Different biomaterials have been designed based on coiled-coil peptides. These biomaterials have a range of applications, inclusing drug delivery, cell sorting to cell-cell fusion.

Endocannabinoids are lipid messengers that modulate various physiological functions by activating the cannabinoid CB1 and CB2 receptors. While the metabolism of endocannabinoids and their action at the CB receptors is fairly well studied, the molecular mechanisms governing their release and transport…

This dissertation aims to advance understanding of amoeboid single cell migration under the influence of changing physicochemical environmental properties. The particular focus is on the relatively unknown influence of differing physical properties in the extracellular environment, such as the migratory…

In this thesis, topics relating to the optimization of high-throughput pipelines used for imaging are discussed. In particular, different levels of implementation, i.e., conceptual, software, and hardware, are discussed and the thesis outlines how advances on each level need to be made to make gains…

This thesis mainly focuses on cross-modal retrieval and single-modal image retrieval via deep learning methods, i.e. by using deep convolutional neural networks.

In this research project, we aimed to obtain more insight in the role of mast cells in the immune driven disorders rheumatoid arthritis and atherosclerosis.

Promotor: W.Th.F. den Hollander, Co-promotor: F.R. Nardi

This thesis describes the use of an activity-based proteomics method to study the endocannabinoid system.

This thesis covers several aspects of quantum algorithms for near-term quantum computers and its applications to quantum chemistry and material science.

Pericytes, the mural cells of blood microvessels, are important regulators of vascular morphogenesis and function that have been postulated to mechanically control microvascular diameter through as yet unknown mechanisms.

Promotor: Erik F. Smets, Co-promotores: Barbara Gravendeel, Niels Raes

The work in this thesis describes the fundamental role of Lkb1 as a conductor of metabolism-related processes in zebrafish larvae.

This thesis contributes to studying primordial cosmology theories and their detectability in future observations.

Promotor: Prof.dr. H.L.V. Linnartz

The focus of this thesis is on the technical methods which help promote the movement towards Trustworthy AI, specifically within the Inspectorate of the Netherlands.

This thesis investigates the evolution and fate of gaseous exoplanets, which are continuously shaped by stellar activity across both short and long timescales.

De afdeling Staats- en Bestuursrecht van de Universiteit Leiden heeft een bundel gepubliceerd over de vraag of de historisch gegroeide combinatie van de concepten van democratische legitimiteit en de scheiding van machten mogelijk blijft buiten de context van de traditionele staat, en indien dit mogelijk…

Naast het speuren door vrijwilligers loopt er ook onderzoek naar de inzet van kunstmatige intelligentie bij de zoektocht naar onontdekte archeologische structuren.

Op donderdag 20 augustus vindt in de Burumazaal van het Onderwijsgebouw van het LUMC de feestelijke bijeenkomst Vision on Statistical Science and Information on the Masters Programme plaats. Dit is de openingsbijeenkomst van de bijzondere masterspecialisatie Statistical Science for the Life and Behavioral…

De onderzoeksgroep Business, Technology & Public Policy van de afdeling Bedrijfswetenschappen van Universiteit leiden houdt zich bezig met het onderzoeken van de dynamische wisselwerking tussen ‘nieuwe’ technologieën en de verschillende belanghebbenden die hiermee interacteren, waaronder consumenten,…

Een internationaal team van onderzoekers, met onder hen Matthieu Schaller van de Sterrewacht Leiden en het Leids Instituut voor Onderzoek in de Natuurkunde, heeft de grootste en nauwkeurigste virtuele weergave van ons heelal tot nu toe geproduceerd. De onderzoekers hebben supercomputersimulaties gebruikt…