The research described in this Thesis was aimed at designing and synthesizing nature-inspired compounds as part of TB vaccine discovery.

In photoactivated chemotherapy (PACT), a biologically active compound is caged by a light-cleavable protecting group.

Voor de omzetting van zonlicht naar brandstof

De olympiades zijn jaarlijkse wedstrijden in (exacte) vakken waar alle scholieren in de bovenbouw van havo en vwo aan mee kunnen doen. De Universiteit Leiden werkt mee aan de volgende Olympiades:

Fundamental understanding of molecular reactions on metal surfaces is important for improving heterogeneous catalysis.

Promotor: Prof.dr. H.J.M. de Groot, Co-promotor: Francesco Buda

Heterogeneous catalyzed processes are highly significant to the chemical industry. Dissociative chemisorption (DC) of molecules on surfaces is always considered as a step with a high degree of rate control for heterogeneous catalysis.

This dissertation focused on computational methods based on first principles calculations using the Density Functional Theory (DFT) framework. Emphasis was laid on affordable methods that can provide a tradeoff between computational expense and accuracy.

Promotors: Prof.dr. E. Bouwman, Prof.dr. E. Drent

Light-Harvesting Complex II (LHCII) is responsible for light absorption and excitation energy transfer in plants and photosynthetic algae, while in high light it undergoes conformational changes by which it quenches excitations to prevent photodamage.

This Thesis describes the design, synthesis and evaluation as glycoprocessing enzyme inhibitors of focused libraries of iminosugars.

Glycosidases are important enzymes in the turnover of polysaccharides and glycoconjugates, and are involved in a range of human pathologies including genetic disorders such as Gaucher and Pompe disease, but also in various cancers.

Promotor: M. Ubbink, Co-promotor: G. Siegal

This thesis provides an overview of the development of the Pair Configuration to Molecular Activity Coefficient (PAC-MAC) model.

Promotores: H.S. Overkleeft, G.A. van der Marel, Co-Promotor: J.D.C. Codee

An objective of this research was to achieve direct, well-defined and non-rate-limiting electron transfer between respiratory enzymes and the electrode surface by means of 'Q-wires'.

Dissociative chemisorption is an important reaction step in many catalytic reactions.

In this thesis we have discussed several parameters that affect the electrochemical conversion of enviromentaly harmful molecules such as nitrates and carbon dioxide to more valuable and less deleterious compounds, in order to cast light onto the mechanism of the reaction to achieve an efficient and…

This thesis advance our understanding and the application of molecular catalysts relevant to the reduction of oxygen as well as reduction of nitrite.

The aim of this thesis is to explore the use of Bioorthogonal Antigens to study the cross-presentation pathway.

The work in this thesis demonstrates how to obtain an atomic-scale picture of a diverse set of complex surface structures observed using STM, under disparate conditions.

BlaC is the β-lactamase of Mycobacterium tuberculosis. We show that it can recover from inhibition by clavulanic acid and that phosphate helps it do so.

The aim of this thesis is to develop and study a robust and adaptable scaffold for supramolecular polymer self-assembly in water.

In eight chapters, the thesis of Rafaël Vos covers the effect of temperature and pressure on the electrochemical CO2 reduction.

This work has described synthetic strategies towards well-defined structures resembling capsular polysaccharide (CPS) fragments, CPS mimics, teichoic acid (TA) fragments as well as a third-generation ring-closing tandem metathesis (RCM) linker to better exploit the potential of automated synthesis.

Promotor: G. J. Kroes

This thesis focuses on the synthesis, characterization and performance towards CO2 electroreduction of mono and bi-metallic particles based on p-block metals

In this thesis, we consider various (electro)chemical phenomena at surfaces and nanoparticles and their underlying atomistic processes, which we studied using first-principles methods such as density functional theory.

Promotor: Prof.dr. M. Ubbink

Promotor: M.T.M. Koper, Co-Promotor: L.B.F. Juurlink

Molecular complexes can be used as electrocatalysts for oxygen reduction, water oxidation, and/or hydrogen peroxide production.

This thesis investigates the relations between metabolism and anatomy through the use of Magnetic Resonance Imaging (MRI).

Promotor: Prof.dr. M.T.M. Koper, Co-Promotor: F. Calle-Vallejo

The thesis focuses on synthesis strategies in oligosaccharide campaigns, and the influence of protecting groups.

Na het afronden van de bacheloropleiding volgen verreweg de meeste studenten de masteropleiding. De Universiteit Leiden stimuleert studenten om na hun bacheloropleiding door te gaan met de masteropleiding.

The goal of this thesis is to understand how interfacial parameters, such as the addition of organic additives, bulk pH or metal cations of the electrolyte, affect the relevant electrocatalytic reactions, i.e. electrochemical CO2 reduction reaction or hydrogen evolution reaction.

Indonesia is experiencing various environmental challenges related to its fast economic growth. Therefore, it is necessary to have measurable and applicable indicators to obtain accurate data and information regarding the costs of adverse environmental impacts arising from economic activities to support…

The work in this thesis has been focused on two subjects. The first is the assembly of alginate oligosaccharides and the generation of building blocks for the enzymatic synthesis of alginate, and the second is the total synthesis of large fragments of the zwitterionic SP1 polysaccharide.

The disease acute myeloid leukemia (AML) is characterized by fast progression and low survival rates.

This thesis describes the design, synthesis, and immunological evaluation of varying (neo)antigenic peptide conjugates containing either a TLR2 or a TLR7 agonist.

Promotor: M. Ubbink, Co-Promotor: R. T. Dame

Twee onderzoekssamenwerkingen waarbij de Universiteit Leiden betrokken is hebben een grote Europese subsidie, een zogenaamde ERC Synergy Grant, gekregen. Het gaat om onderzoek naar de ontwikkeling van membranen die bijvoorbeeld water en medicijnen kunnen zuiveren en onderzoek naar de biologische klok…

Om goed onderbouwde besluiten over complexe onderwerpen zoals het klimaat, recht en gezondheid te kunnen nemen, zijn wetenschappelijke resultaten van groot belang. Maar wetenschappelijke resultaten bevatten altijd een mate van onzekerheid. Binnen het onderzoek Communicatie over onzekerheden wordt onderzocht…

Aan de hand van de karakteristieke aspecten van een beeld kunnen bepaalde computers ons vertellen wat het beeld laat zien. Ze kunnen dit leren op dezelfde manier als jonge kinderen beelden kunnen leren herkennen. Het verder verbeteren van deze technieken opent de weg naar een hele reeks nieuwe toepassingen.…

Aan de hand van de karakteristieke aspecten van een beeld kunnen bepaalde computers ons vertellen wat het beeld laat zien. Ze kunnen dit leren op dezelfde manier als jonge kinderen beelden kunnen leren herkennen. Het verder verbeteren van deze technieken opent de weg naar een hele reeks nieuwe toepassingen.…

Endothelial dysfunction and microvascular diseases are key drivers of cardiovascular disease, the world's leading cause of death.

Consequences for sediment stability and seston trapping

Promotor: D. Bouwmeester, Co-promotor: D. Kraft

Promotores: Prof.dr. W.J.G.M. Peijnenburg & Dr. M.G. Vijver