This dissertation consists of two parts, with the common theme

This thesis discusses several questions regarding the double ramification cycle as a Chow class on the moduli space of stable n-pointed genus g curves using tools from so-called logarithmic geometry.

Promotor: G.R. de Snoo

Promotor: Jan van der Greef; Co-promotors: Mei Wang; Eduard van Wijk

Cardiovascular disease is the leading cause of death worldwide.

Promotor: Prof.dr. T. Hankemeier

Immunotherapies for cancer are an emerging class of therapeutic strategies which aim to treat cancer via augmentation of the immune system.

Antibiotic resistance, caused by widespread use of antibiotics, leads to bacterial infections that are difficult, if not impossible, to treat and is a major worldwide health concern.

The elementary excitations of magnets are called spin waves, and their corresponding quasi-particles are known as magnons. The rapidly growing field of Magnonics aims at using them as information carriers in a new generation of electronic devices, (almost) free of electric currents.

Promotores: P. Stevenhagen, A. Enge Co-Promotor: T.C. Streng

This thesis deals with properties of Jacobians of genus two curves that cover elliptic curves.

The type-IV secretion system (T4SS) is a machinery able to transfer DNA and proteins between bacteria and in certain cases also to eukaryotic cells.

Acidobacteria is a widely distributed phylum but their functional roles in ecosystem processes are still largely elusive.

Assessing the risks of engineered nanomaterials (ENMs) solely on the basis of experimental assays is time-consuming, resource intensive, and constrained by ethical considerations (such as the principles of the 3Rs of animal testing). The adoption of computational toxicology in this field is a high p…

Science is typically a patchwork of research contributions without much coordination. Especially in clinical trials, the follow-up studies that we do fail to be the most promising.

Promotor: D. Bouwmeester, Co-promotor: D. Kraft

Promotores: Prof.dr. B.R. Katzy, Prof.dr. K. Sailer (Munich University)

Promotor: Prof.dr. J.P. Abrahams, Co-Promotor: N.S. Pannu

Promotor: R. Tijdeman, Co-promotor: H.J.J. te Riele

Promotor: Prof.dr. J. Kuiper

The last decades it is increasingly recognized that acute as well as chronic postoperative pain is an important problem. Treatment and prevention of postoperative pain is a challenge, especially in special patient populations where there is only limited guidance on how to optimally use opioids.

Optical projection tomography (OPT) is a tomographic 3D imaging technique used for specimens in the millimetre scale.

This thesis explores how electron paramagnetic resonance (EPR) spectroscopy can be used to investigate key biochemical processes.

Promotor: C.A.J. Knibbe, Co-promotores: H.P.A. van Dongen, B. van Ramshorst

Dissolving microneedles are a subgroup of microneedle types that completely dissolve within the skin. During this dissolving process the vaccine, stored in the needle matrix, is released into the skin.

Promotor: G.P. van Wezel, Co-promotor: D. Claessen

The different kinds of cultural perspectives on health and disease of the participants are related to their knowledge, beliefs, values and practices manifested in various forms of lifestyle in Indonesia. The cultural diversity of the population is also related to differences in health behaviour.

Promotor: H.W. Lenstra

Promotor: Thomas Hankemeier, Co-promotores: Heiko van der Linden, Paul Vulto

Promotor: Prof.dr. E. Smets, M. Stech

This dissertation presents the results of the importance of creativity for ICT-students of Dutch universities of applied sciences (in Dutch: hogescholen), and the functioning of training courses that aim to promote creative abilities is highlighted.

Monoacylglycerol lipase (MAGL) is the principal enzyme responsible for hydrolysis of the endocannabinoid 2-arachidonoylglycerol (2-AG). MAGL inhibition provides several potential therapeutic opportunities, including anti-nociceptive, anti-inflammatory and anti-cancer activity.

Promotor: Prof.dr. H.J.A. Rottgering

Time-series forecasting through modelling sequences of temporally dependent observations has many industrial and scientific applications. While machine learning models have been widely used to create time-series forecasting models, creating efficient and performant time-series forecasting models is…

Streptomyces present a valuable platform for natural product discovery. Lugdunomycin is a novel angucycline-derived polyketide from Streptomyces sp QL37, with unprecedented skeleton and antimicrobial activity.

The redox-conversion reaction of metal-disulfide and metal-thiolate complexes are important, as they may shed light on electron-transfer reactions that often occur in Nature.

Promotor: Bas Edixhoven, Promotor: Qing Liu

Salicylic acid (SA) is a plant hormone, which is involved in the defense responses to pathogens and to abiotic stress, and in the regulation of plant growth and development.

Lezing

Lezing

Lezing

Promotor: S.J. Edixhoven, Co-promotor: R.S. de Jong

Promotor: Prof.dr. T. Hankemeier, Prof.dr. J.C.T. Eijkel (Twente University)

The vegetative growth period for leafy vegetables like lettuce is essential for yield and quality.

Promotor: Prof.dr. G.R. de Snoo, Co-promotor: R. Heijungs

De meest bijzondere afbeeldingen, kledingstukken en andere unieke voorwerpen uit de vier eeuwen tellende geschiedenis van de universiteit zijn nu te zien bij ‘Celebrating Curiosity’. Vier stukken uit deze expositie uitgelicht.

Louis Sicking gaat met het Dr. Ernst Crone Fellowship van het Scheepvaartmuseum in Amsterdam onderzoek verrichten naar een uniek scheepsmodel in zijn collectie: het model van een oorlogsschip uit 1560.

Wie aan inlichtingenwerk denkt, denkt aan James Bond. De dagelijkse praktijk is gelukkig genuanceerder. In Vijandbeelden bespreekt Constant Hijzen het werk besproken van de Nederlandse inlichtingen- en veiligheidsdiensten, vroeger en nu.

Niemand zal ontkennen dat Joost van den Vondel de grootste toneeldichter van de Gouden Eeuw is geweest, maar de publieksprijs ging naar andere toneelschrijvers. De Spaanse comedias van topauteurs als Félix Lope de Vega y Carpio (1562-1635) en Pedro Calderón de la Barca (1600-1681) waren razend popul…

Van gewone middeleeuwers zijn nauwelijks geschreven documenten overgeleverd. Hoe zij dachten over de leer van de kerk weten wij dus niet uit de eerste hand. Toch valt er iets te zeggen over de manier waarop mensen in de huiselijke kring en het maatschappelijk leven uiting gaven aan hun geloof.