Interactive exploration of large volumes of data is increasingly common, as data scientists attempt to extract interesting information from large opaque data sets. This scenario presents a difficult challenge for traditional database systems, as (1) nothing is known about the query workload in advance,…

Vitamin A or retinol is essential in embryonic development, the visual cycle and the immune system.

Promotor: B. van de Water

Despite being the object of intense study, embryonic development has been difficult to model due to a number of reasons. First, complex tissues can be comprised of many cell types, of which we probably only know a subset.

The field of exoplanet research is rapidly advancing through the development of new technology, observing techniques, and post-processing methods.

Immunotherapies for cancer are an emerging class of therapeutic strategies which aim to treat cancer via augmentation of the immune system.

This thesis describes how to scale down concepts of macroscopic mechanical metamaterials to the thermal scale using a system of flexibly-linked colloids.

What are the pressing issues of our time, and how can different disciplines come together to address them? Studium Generale and Leiden University College (LUC) present the Global Challenges series: events that bring together researchers from LUC and experts from other disciplines to tackle a shared…

This thesis is a (biased) journey through very different topics in astrophysics: quasars and new populations of active galactic nuclei, gravitational waves from merging black holes, and protoplanetary discs around young stars.

This dissertation investigates how the efficiency of Computed Tomography (CT) can be improved for dynamic scientific and industrial applications.

Taalkundige Johan Rooryck gaat onderzoek doen naar leervermogen en kernkennissystemen, en hoe bezit in verschillende talen wordt uitgedrukt. Samen met collega-onderzoekers heeft hij twee NWO-subsidies van in totaal 2,75 miljoen euro ontvangen voor de onderzoeksprogramma’s ‘Knowledge and Culture’ en…

Tijdens de ILS Lunch Seminars kunnen alle onderzoekers van de faculteit hun onderzoek presenteren. Het doel is om op een toegankelijke en efficiënte manier op de hoogte zijn van onderzoeken van verschillende onderzoeksprogramma's en instituten. Gedurende een seminar van een uur zullen twee of drie sprekers…

Afgelopen weekend heeft Italië aan Nederland verzocht twee schepen terug te roepen die onder de Nederlandse vlag varen voor de Libische kust.

Promotor: Prof.dr. S.F. Portegies Zwart

My PhD research is devoted to studies of the conjectural cluster-algebraic symmetry in the theory of topological string, which is the simplest, however already non-trivial sector in the theory of string.

Promotores: Prof.dr. C.U. Keller, Prof.dr. H.C. Gerritsen

Promotor: Prof.dr. J.G.E.M. Fraaije, Co-promotor: A. Kros

What holds people together and what makes them willing to fit within larger political structures? Our project examines this question in the practices of dynastic rulership in Eurasia ca. 1300-1800.

Het Data Science Onderzoeksprogramma (DSO) combineert Leidse promotieonderzoeken uit allerlei disciplines met data science. Het programma loopt nu ruim twee jaar, en levert verrassende eerste resultaten op. Hieronder vertellen een aantal promovendi over hun ervaringen en hun onderzoek.

Sinds 2009 behaalden 95 kandidaten hun doctoraat in Creative en Performing Arts. Op deze pagina een overzicht van ACPA's alumni.

Eerlijke en creatieve AI

Op vrijdag 24 maart aanstaande zal Prof. Amanda Perry–Kessaris (Kent Law School) de maandelijkse Leiden Socio-Legal Lecture verzorgen.

Maandag 23 mei, 16.00 -17.00 uur, zaal 174 Snellius, Niels Bohrweg 1, 2333 CA Leiden.

De maatschappelijke aandacht voor slachtoffers van criminaliteit is de afgelopen decennia enorm gegroeid en zo ook de behoefte aan goed onderzoek op het gebied van de victimologie, de wetenschappelijke studie van slachtoffers en slachtofferschap. Binnen het CJ-onderzoeksprogramma wordt hard gewerkt…

The path to rational drug and dose selection

This interdisciplinary minor addresses sustainabilty challenges from a systems perspective, and investigates ways to sustain society within planetary boundaries.

Cardiovascular disease is a major global burden and atherosclerosis is the main underlying pathological process.

Freshwater and brackish water ecosystems are arguably the most vulnerable ecosystems on earth, due to concentrated human developments in and around them. The Pontocaspian (PC) region located at the border of Europe and Asia contains a variety of brackish water ecosystems and unique inhabitants, known…

Promotores: Prof.dr. G.F.A. Kersten, W. Jiskoot, Co-promotor: J-P. Amorij

A complex community of microbes develops in the infant gut shortly after birth. We call this community the infant gut microbiota. The microbiota influences the health of the infant, which makes the composition and function of the infant gut microbiota an important topic to study.

The subject of this thesis, ‘Approach to Markov Operators on Spaces of Measures by Means of Equicontinuity’, combines an analytical and probabilistic approach to Markov operators.

Promotor: W. Jiskoot, Co-promotor: A. Hawe

Inactivating mutations in BRCA1 or BRCA2 genes predispose to several types of cancer.

Geometric phases lead to a nontrivial interference result when an electron's different quantum mechanical paths choices encircle a magnetic coil in an Aharonov-Bohm experiment.

Inverse problems are problems where we want to estimate the values of certain parameters of a system given observations of the system. Such problems occur in several areas of science and engineering. Inverse problems are often ill-posed, which means that the observations of the system do not uniquely…

Viral hemorrhagic fever (VHF) is a group of acute diseases caused by highly infectious viruses including Ebola, Lassa, Dengue viruses. Its high mortality rate poses high risk to public health, however, studies on VHF have been hampered due to the non-availability of proper models and incomplete knowledge…

Promotor: Prof.dr. T. Hankemeier, Co-promotor: Theo Reijmers

The aim of the research presented in this thesis was to develop new methods forchallenging systems in liquid-state NMR using paramagnetic effects generated by thetwo-armed probe CLaNP-5.

Large areas of space are filled by molecular clouds that consist of gas and dust grains that are the remnants of dead stars. When these clouds start collapsing, the decreasing temperature and increasing density cause gas particles to start accreting onto dust grain surfaces.

Producing green energy has become the main goal in our society in the search of reducing or eliminating the carbon emission from fossil fuels.

This thesis investigates catalytic reactions at the atomic scale using scanning tunneling microscopy (STM), with a focus on Fischer–Tropsch synthesis, a key industrial process that converts hydrogen and carbon monoxide into liquid fuels.

Sinds de oprichting is LUC een college voor onderwijsontwikkeling en experimentatie. In de missie van het college wordt LUC beschreven als "een plek van innovatie op het gebied van didactiek, curriculumontwerp en studentwelzijn." Deze visie wordt toegepast via een studentgerichte benadering in het onderwijs…

Lysosomal acid glucosylceramidase (GBA1) is a lysosomal enzyme that degrades glucolipids with its main substrate being glucosylceramide (GlcCer). Defects in the GBA1 gene lead to glycosphingolipidosis Gaucher disease (GD), in which the hydrolysis of GlcCer is impaired and therefore, it accumulates in…

Acht op de tien experimentele geneesmiddelen overleven de testfase op patiënten niet. Piet Hein van der Graaf, hoogleraar Systeemfarmacologie, wil die verspilling van tijd en geld voorkomen met nieuwe meet- en rekenmethoden.