2,411 zoekresultaten voor “computational modelling” in de Publieke website
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Turtles all the way down: multiscale simulations connecting star and planet formation
The formation of stars and planets happens over multiple scales, which can interact. In particular, planet formation happens in the dense, complex environment of star forming regions.
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The Sky is Made of Lava: How lava worlds reveal their interiors through their atmospheres
Hot rocky exoplanets are planets that orbit so close to their host star that they possess a molten surface.
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Towards artificial photosynthesis: resolving supramolecular packing of artificial antennae chromophores through a hybrid approach
Promotor: H.J.M. de Groot
- Technologie in het onderwijs
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Tekenen en schilderen
Kunst en vrije tijd, Kunst en vrije tijd
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"Het hele concept is gericht op activering van het onderwijs"
Elke student is bekend met de huidige vorm van hoorcolleges volgen. Je komt, je luistert en je gaat weer naar huis. Prof.dr. Frans-Willem Korsten introduceert het al bekende idee van 'Flipping the Classroom' nu aan onze faculteit, als een nieuwe vorm van onderwijs geven.
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Liesbeth de Lange wint Lewis B. Sheiner Carrièreprijs
Farmacoloog Liesbeth de Lange heeft de Lewis B. Sheiner Lecturer Award van de International Society of Pharmacometrics (ISoP) gewonnen. Als hoogleraar Voorspellende Farmacologie werkt ze onder andere aan een wiskundig model dat medicijnconcentraties in de hersenen kan voorspellen. Ter gelegenheid van…
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Bas van Opheusden wint Janneke Fruin-Helb Beurs voor netvliesonderzoek aan Princeton University
Bas van Opheusden, student theoretisch natuurkunde, is de winnaar van de Janneke Fruin-Helb Beurs 2012. Van Opheusden schreef een voorstel voor een verblijf aan het gerenommeerde Amerikaanse onderzoeksinstituut Princeton University . Hij doet daar aan het institute for computational neuroscience een…
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Marcus Specht sluit aan bij PERL als Hoogleraar Digital Education
Marcus Specht, directeur van het LDE Center of Education and Learning, is sinds 15 november aangesteld als Hoogleraar Digital Education. Hij heeft gezamelijke benoemingen bij de drie LDE universiteten. In Leiden zal hij zich aansluiten bij Felienne Hermans in het Programming Education Research Lab (…
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Vroege jager-verzamelaars veranderden ver voor de eerste landbouw al de ecosystemen van Europa
Een nieuw onderzoek van de Leidse archeologe Anastasia Nikulina en een internationaal team uit Frankrijk, Denemarken, het Verenigd Koninkrijk en Nederland, weerlegt het idee dat jager-verzamelaars vóór de opkomst van de landbouw een verwaarloosbare impact hadden op hun leefomgeving.
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Marlies Reinders
Integratie van MOOC in campus
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Onderzoek bij het Levend Lab
Wat doen bestrijdingsmiddelen, bemesting of plastic met de waterkwaliteit? En hoe beïnvloeden wind en regen de data? Dat en meer onderzoeken de Leidse milieuwetenschappers in de 32 sloten van het Levend Lab.
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Over het programma
In 2020 zijn de stimuleringsprogramma's van de Universiteit Leiden gestart, met als één van de programma's regeneratieve geneeskunde.
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Onderzoeksverhalen
Meer weten over ons onderzoek met proefdieren of ons onderzoek naar proefdiervrije alternatieven? Bekijk de nieuwsberichten in de rechterbalk (voor mobiele gebruikers onderaan).
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From labelled to the optimal clinical dose: Model-informed dose optimization in medical oncology practice
Promotie
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Begeleiding en beoordeling praktijk
De studieonderdelen die betrekking hebben op het functioneren van studenten in de onderwijspraktijk zijn Praktijk 1 (eerste deel van de opleiding) en Praktijk 2 (tweede deel van de opleiding).
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C-SCAPE - Sandy strategies for sustainable coastal climate change adaptation
What is the optimal design of sandy solutions for sustainable climate change adaption, from an ecological, biophysical and societal point of view?
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Groen geluk
De relatie tussen natuur en welbevinden
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Efficiëntere geneesmiddelenontwikkeling met hulp van computermodellen
Het coronavirus heeft de wereld in zijn greep. Het vinden van een medicijn is nog nooit zo belangrijk geweest. Helaas zijn de ontwikkeling van nieuwe medicijnen en de ontwikkeling van een vaccin complexe, langdurige en vooral kostbare processen. Computermodellen kunnen dit proces versnellen. Wetenschappers…
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What Determines Perceptions of Bias toward the International Criminal Court? Evidence from Kenya
What Determines Perceptions of Bias toward the International Criminal Court? Evidence from Kenya. In dit artikel, gepubliceerd in op de website SAGE Journals in het Journal of Conflict Resolution, onderzoeken de auteurs Geoff Dancy, Yvonne Marie Dutton, Tessa Alleblas, Eamon Aloyo de houding ten opzichte…
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Synthetic peptides as tools in chemical immunology
This thesis has described novel synthetic methods to produce a variety of (glyco)peptides and their application in the study of various immunological processes.
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From intracluster medium dynamics to particle acceleration
The intracluster medium (ICM) is a hot, tenuous and X-ray emitting gas that pervades galaxy clusters.
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Dynamics of TNFalpha signaling and drug-related toxicity
In previous studies at our laboratory it was demonstrated that drug exposure of HepG2 cells can lead to an altered TNFα-induced NF-κB oscillatory phenotype, concurrent with a synergistically increased sensitivity for TNFα-induced apoptosis.
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Innovative Faculty Developement towards Inclusive Student-centred Pedagogy
E-boek over inclusief en studentgericht hoger onderwijs
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This is life: some thoughts on self-organized structure formation in active liquids and biological systems
It has been a long-standing mystery how complex biological structures emerge from such seemingly uncoordinated building blocks as cells and tissues, in the presence of only minimal environmental guidance.
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Signalling pathways that control development and antibiotic production in streptomyces
Bacteria are highly complex and diverse organisms that have adapted to survive in ecological niches ranging from the most extreme to the most heterogeneous environments.
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Onderwijs
Als groep verzorgen we ook onderwijs binnen het instituut Pedagogische Wetenschappen.
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Satellite remote sensing of plant functional diversity
Biodiversity enables ecosystems to thrive through the synergy of functional differences among organisms. While human well-being strongly depends on biodiversity-driven ecosystem services, human actions are also at the root of current unprecedented biodiversity declines.
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The flexible listener: exploring zebra finch sensitivity to spectral and temporal sound features
Human vocal communication and music perception represent advanced cognitive skills, seemingly innate and universal. These faculties encompass a range of perceptual and cognitive abilities. Cross-species research sheds light on the origins of musicality by investigating whether these traits are shared…
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Patterns in natural systems
Promotor: A. Doelman, Co-promotores: P.J.A. van Heijster; A. Zagaris
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On the geometry of demixing: A study of lipid phase separation on curved surfaces
Like a mixture of oil and water, lipid membranes separate into two liquid phases.
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The role of zebrafish larvae for studying anxiety-like behaviour
The main aim of my Ph.D. thesis is to further explore the value of using early developing zebrafish larvae (up to 5 dpf) as a model to study anxiety-like behaviour and their pharmacological modulation with drugs.
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Studies on the Pathogenesis of Chronic Kidney Disease
In this thesis, two potential therapeutic targets for diabetic nephropathy were dentified and investigated. First, we show that glomerular clusterin is upregulated in diabetic nephropathy and demonstrated that recombinant clusterin protein can protect the podocytes against oxidative stress in vitro.…
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Exploring deep learning for multimodal understanding
This thesis mainly focuses on multimodal understanding and Visual Question Answering (VQA) via deep learning methods. For technical contributions, this thesis first focuses on improving multimodal fusion schemes via multi-stage vision-language interactions.
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Squaramide-based supramolecular polymers : from self-assembly to in vivo application
The aim of this thesis is to develop and study a robust and adaptable scaffold for supramolecular polymer self-assembly in water.
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Coiled-coil biomaterials for biological applications
This dissertation contains four works during my PhD. Different biomaterials have been designed based on coiled-coil peptides. These biomaterials have a range of applications, inclusing drug delivery, cell sorting to cell-cell fusion.
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Release and transport of endocannabinoids
Endocannabinoids are lipid messengers that modulate various physiological functions by activating the cannabinoid CB1 and CB2 receptors. While the metabolism of endocannabinoids and their action at the CB receptors is fairly well studied, the molecular mechanisms governing their release and transport…
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Amoeboid cell migration and physicochemical properties of the extracellular environment
This dissertation aims to advance understanding of amoeboid single cell migration under the influence of changing physicochemical environmental properties. The particular focus is on the relatively unknown influence of differing physical properties in the extracellular environment, such as the migratory…
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Exploring Deep Learning for Intelligent Image Retrieval
This thesis mainly focuses on cross-modal retrieval and single-modal image retrieval via deep learning methods, i.e. by using deep convolutional neural networks.
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Mast cell-mediated immune modulation in experimental Rheumatoid Arthritis and Atherosclerosis
In this research project, we aimed to obtain more insight in the role of mast cells in the immune driven disorders rheumatoid arthritis and atherosclerosis.
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Metastability for low-temperature Kawasaki dynamics with two types of particles
Promotor: W.Th.F. den Hollander, Co-promotor: F.R. Nardi
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Activity-based proteomics of the endocannabinoid system
This thesis describes the use of an activity-based proteomics method to study the endocannabinoid system.
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Optimization of quantum algorithms for near-term quantum computers
This thesis covers several aspects of quantum algorithms for near-term quantum computers and its applications to quantum chemistry and material science.
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Force sensing and transmission in human induced pluripotent stem-cell-derived pericytes
Pericytes, the mural cells of blood microvessels, are important regulators of vascular morphogenesis and function that have been postulated to mechanically control microvascular diameter through as yet unknown mechanisms.
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Evolutionary diversification of Nepenthes (Nepenthaceae)
Promotor: Erik F. Smets, Co-promotores: Barbara Gravendeel, Niels Raes
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The role of the tumor suppressor Lkb1 in energy homeostasis
The work in this thesis describes the fundamental role of Lkb1 as a conductor of metabolism-related processes in zebrafish larvae.
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Hunting for new physics in the primordial Universe
This thesis contributes to studying primordial cosmology theories and their detectability in future observations.
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Hydrocarbons in interstellar ice analogues: UV-vis spectroscopy and VUV photochemistry
Promotor: Prof.dr. H.L.V. Linnartz
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Reliable and Fair Machine Learning for Risk Assessment
The focus of this thesis is on the technical methods which help promote the movement towards Trustworthy AI, specifically within the Inspectorate of the Netherlands.
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The Evolutionary Tale of Gaseous Exoplanets
This thesis investigates the evolution and fate of gaseous exoplanets, which are continuously shaped by stellar activity across both short and long timescales.