Glycosidases are essential in fundamental biological processes and are responsible for the degradation of most (oligo)saccharides, glycolipids and glycoproteins.

We investigate the buildup of galaxies from various vantage points. The first two chapters focus on the stellar content of galaxies, especially the distribution of stellar masses at birth and potential variations therein in various galactic environments.

An Active Galactic Nucleus (AGN) is a highly luminous region at the center of a galaxy, powered by the accretion into a supermassive black hole and emitting energy from radio waves to gamma rays, often outshining the host galaxy.

Promotor: T.H. Oosterkamp

Promotor: S.M. Verduyn Lunel

Balsaminaceae is a diverse plant family characterized by a huge floral morphological diversity.

This dissertation presents the results of the importance of creativity for ICT-students of Dutch universities of applied sciences (in Dutch: hogescholen), and the functioning of training courses that aim to promote creative abilities is highlighted.

Promotor: Prof.dr. H.J.A. Rottgering

Pectin is a plant cell wall polysaccharide made of mainly D-galacturonic acid (GA) subunits. The potency of the filamentous fungus Aspergillus niger to naturally secrete high amounts of pectinases to degrade pectin has been utilized for the industrial production of pectinases.

Drug-induced liver injury (DILI) is one of the main reasons for drug attrition during pre-clinical and clinical phases of drug development as well as for drug withdrawal post-marketing.

Promotor: Thomas Hankemeier, Co-promotores: Heiko van der Linden, Paul Vulto

Promotor: Prof.dr. T. Hankemeier

The effective treatment of tuberculosis (TB) remains a major challenge to global health.

Streptomyces present a valuable platform for natural product discovery. Lugdunomycin is a novel angucycline-derived polyketide from Streptomyces sp QL37, with unprecedented skeleton and antimicrobial activity.

Monoacylglycerol lipase (MAGL) is the principal enzyme responsible for hydrolysis of the endocannabinoid 2-arachidonoylglycerol (2-AG). MAGL inhibition provides several potential therapeutic opportunities, including anti-nociceptive, anti-inflammatory and anti-cancer activity.

Time-series forecasting through modelling sequences of temporally dependent observations has many industrial and scientific applications. While machine learning models have been widely used to create time-series forecasting models, creating efficient and performant time-series forecasting models is…

Promotor: Prof.dr. E. Smets, M. Stech

The different kinds of cultural perspectives on health and disease of the participants are related to their knowledge, beliefs, values and practices manifested in various forms of lifestyle in Indonesia. The cultural diversity of the population is also related to differences in health behaviour.

Dissolving microneedles are a subgroup of microneedle types that completely dissolve within the skin. During this dissolving process the vaccine, stored in the needle matrix, is released into the skin.

Promotors: C.A.J. Knibbe, Anthonius de Boer, Co-promotor: M.M.J. van der Vorst

The redox-conversion reaction of metal-disulfide and metal-thiolate complexes are important, as they may shed light on electron-transfer reactions that often occur in Nature.

Promotor: Bas Edixhoven, Promotor: Qing Liu

Promotor: Prof.dr. G.R. de Snoo, Co-promotor: R. Heijungs

Promotor: G.P. van Wezel, Co-promotor: D. Claessen

Promotor: Prof.dr. J.P. Abrahams, Co-Promotor: N.S. Pannu

The type-IV secretion system (T4SS) is a machinery able to transfer DNA and proteins between bacteria and in certain cases also to eukaryotic cells.

The mycorrhizal symbiosis is among the most widespread species interactions on Earth⁠. This thesis focuses on orchid mycorrhiza, a unique mycorrhizal type that has caught scientists’ attention for centuries⁠.

Promotor: M. Danhof, Co-promotor: E.C.M. de Lange

Principles of Environmental Sciences provides a comprehensive picture of the principles, concepts and methods that are applicable to problems originating from the interaction between the living and non-living environment and mankind. Both the analysis of such problems and the way solutions to environmental…

Assessing the risks of engineered nanomaterials (ENMs) solely on the basis of experimental assays is time-consuming, resource intensive, and constrained by ethical considerations (such as the principles of the 3Rs of animal testing). The adoption of computational toxicology in this field is a high p…

One of the key limitations of the direct imaging of exoplanets at small angular separations are quasi-static speckles that originate from evolving non-common path aberrations (NCPA) to which the primary adaptive optics system is inherently blind. The main focus of this thesis is the development and…

This thesis explores how electron paramagnetic resonance (EPR) spectroscopy can be used to investigate key biochemical processes.

Promotor: C.A.J. Knibbe, Co-promotores: H.P.A. van Dongen, B. van Ramshorst

Building a Deep Cross-media Transfer Network to extract visual relations that relieve the problem of insufficient training data for visual tasks.

Promotor: S.M. Verduyn Lunel

The elementary excitations of magnets are called spin waves, and their corresponding quasi-particles are known as magnons. The rapidly growing field of Magnonics aims at using them as information carriers in a new generation of electronic devices, (almost) free of electric currents.

Salicylic acid (SA) is a plant hormone, which is involved in the defense responses to pathogens and to abiotic stress, and in the regulation of plant growth and development.

Mycoheterotrophy is a particular mode of life in which plants obtain carbohydrates from their associated fungal partners, instead of by using photosynthesis.

Acidobacteria is a widely distributed phylum but their functional roles in ecosystem processes are still largely elusive.

Promotor: Prof.dr. F. den Hollander, G.Maillard

Promotor: H.W. Lenstra

Promotores: P. Stevenhagen, A. Enge Co-Promotor: T.C. Streng

During post-embryonic development into adults, animals face an environment that fluctuates constantly. For example, in nutrient availability, temperature, and osmolarity (e.g., salt concentration).

Mining time series is a machine learning subfield that focuses on a particular data structure, where variables are measured over (short or long) periods of time.

The unit residue group, to which the present thesis is devoted, is defined using the norm-residue symbol, which Hilbert introduced into algebraic number theory in 1897.

Promotor: Prof.dr. J. den Hertog

Promotor: R. Tijdeman, Co-promotor: H.J.J. te Riele

The last decades it is increasingly recognized that acute as well as chronic postoperative pain is an important problem. Treatment and prevention of postoperative pain is a challenge, especially in special patient populations where there is only limited guidance on how to optimally use opioids.

This thesis deals with properties of Jacobians of genus two curves that cover elliptic curves.

Optical projection tomography (OPT) is a tomographic 3D imaging technique used for specimens in the millimetre scale.