To improve treatment of breast cancer patients it is important to understand all stages of breast cancer from initiation to in situ disease and progression to invasive disease. In this thesis we use intraductal injections of patient derived tissue to model ductal carcinoma in situ and invasive breast…

In het onderzoeksprogramma Drug Discovery & Safety zijn we geïnteresseerd in de werkzaamheid en veiligheid van nieuwe medicijnen en nieuwe manieren om deze aspecten te bepalen. Daarvoor combineren we geavanceerde imaging en high-throughput screening technieken met computationele aanpakken zoals chem-…

Exploring metabolomics-based biomarkers for diagnosis and treatment response monitoring of community-acquired pneumonia

The cannabinoid receptor type 2 (CB2R) is associated with several inflammatory diseases with an unmet medical need (e.g. Alzheimers, multiple sclerosis, reumatoid arthritis). Development of new chemical biology strategies to study this protein is essential to aid future development of drugs for these…

The basic program comprises a total of twelve courses organized by the Research School, that have been purpose-developed for training and support of PhD students and Research MA students who specialize in Medieval Studies (history, art history, and literary history, in particular).

Hieronder vind je een overzicht van de publicaties van LAPP.

Orthopedagogen Adriana Bus, Carienke Kegel en Heleen van den Berg hebben van de gemeente Leiden een subsidie van €120.000 gekregen voor het project ‘De eerste 30 miljoen woordjes’. Met dit project willen zij het taalaanbod dat jonge kinderen krijgen, verbeteren.

The mission of our group is understanding how science communication works to improve the interaction between science and society. We believe better science communication can improve our society and engage many different groups with science, also improving science.

Our recent excavations have focused on the more recent New Kingdom/Late Period (ca. 1500-332 BCE) material.

This thesis investigates opinion dynamics on random graphs through the lens of the voter model, a classical interacting particle system used to describe how consensus emerges in networks.

Promotor: Prof.dr. P.G.L. Klinkhamer, Co-Promotor: T.J. de Jong

Promotor: K.J. Batenburg, Co-promotor: A.W. van der Vaart, B. de Smit

It has now been well established that shocks and turbulent motions in the intra-cluster medium (ICM) generated through cluster mergers can produce large-scale synchrotron emission.

Large carnivores and humans, along with their livestock, have co-existed for thousands of years. However, human population growth and an increase in economic activities are modifying the landscape for large carnivores and their prey.

The endocannabinoid receptors CB1R and CB2R are involved in a plethora of processes, and consequently are involved in many pathological conditions. Their wide distribution makes the CBRs both an interesting therapeutic target and hard to study.

Promotor: Prof.dr. I.A.G. Snellen, C.U. Keller

This thesis seeks to combine two different research topics; Multi-Objective Optimization and Complex Network Analysis.

Promotor: R. Verpoorte, Co-promotores: Y.H.Choi, N.R. Mustafa

Are you planning to conduct clinical research in the Netherlands? In this online course, you are introduced to legislation and procedures on clinical research in the Netherlands. It will help you prepare and submit your research file efficiently. The first three themes ‘The Dutch Review System’ , ‘The…

Image-Pro Plus, ImageJ, Cell Profiler, R, Knime en NIS-elements

Promotie

Promotie

Lezing

Graduation MIRD Class of 2024: 'The world is better off with students like this'

Per 1 september volgt Pablo Pandocchi Thirza van 't Rood op als student-lid van het Instituutsbestuur het komend academisch jaar. Het IB is verantwoordelijk voor alle zaken die het instituut aangaan, van onderwijs tot onderzoek op het gebied van antropologie en sociologie. Tweedejaars student CADS Pablo…

Dr. Charlene Kalle and dr. Tim van Erven, both assistant professors at the Mathematical Institute of Leiden University have received a TOP grant for Physical Sciences from the NWO (The Netherlands Organization for Scientific Research).

Explore how cultural heritage can proactively respond to global crises, from geopolitical conflicts to climate change, through innovative cross-cultural collaboration between Latin American stakeholders and Una Europa.

Despite their ecological, cultural, and economic importance, lion (Panthera leo) populations in Kenya are declining rapidly due to retaliatory killings following livestock depredation, depletion of wild prey, habitat loss driven by human activities, climate change, and disease.

The clinical potential of applying synthetic lethality to cancer treatment is famously demonstrated by the BRCA1/PARP1 paradigm: a tumor specific defect in BRCA1 – a component of the DNA double-strand break (DSB) repair pathway homologous recombination (HR) – results in a remarkable sensitivity to PARP1…

Promotor: A.P. IJzerman Co-promotor: L.H. Heitman

Promotores: Prof.dr. T.H.W. Bäck, Prof.dr. M.R.V. Chaudron, Co-Promotor: M.T.M. Emmerich

A difficulty of studies on chemical kinetics are the reaction time scales and detection of their intermediates.

This dissertation explores how we can make anomaly detection—identifying unusual or faulty behavior in complex systems—more trustworthy and effective, with a focus on smart manufacturing.

Promotor: Prof.dr. E. Bouwman, Co-promotor: S. Bonnet

Promotores: Prof.dr. H.J.M. de Groot, Prof.dr. J. Matysik (Universitaet Leipzig)

The intradermal administration route is attractive for vaccine delivery, because of the highly populated antigen-presenting cells in the skin. However, the skin’s main physical barrier, the stratum corneum, prevents vaccines from entering the skin.

Promotor: P. Stevenhagen, Co-promotor: R.M. van Luijk

Ontdek de cursus Communicating in Legal English van de Leiden Law Academy en verbeter uw juridisch Engelse vaardigheden. Lees hier meer!

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De helft van de wereldbevolking zou kunnen leven van voedsel uit eigen land. Dat blijkt uit het onderzoek van milieuwetenschapper Nicolas Navarre. Voor de andere helft is dat minder simpel. Maar niet onmogelijk. 'Door de gewasproductie te verbeteren, minder voedsel te verspillen en eetgewoontes te veranderen…

Depressie bij jongeren wordt vaak benaderd als een individueel probleem. Maar wie alleen naar het kind kijkt, mist een belangrijk deel van het verhaal, stelt promovenda Myrthe Veenman: ‘Ouders doen ertoe’.

The study of orchid flowers, fruits, and inflorescences is crucial due to the remarkable diversity of orchid species and their unique adaptations to pollinators and seed dispersers. However, our understanding of the evolution and development of these organs within the orchid family remains limited.

The plant hormone auxin regulates plant growth and development through polar cell-to-cell transport-generated maxima and minima. PIN FORMED (PIN) auxin efflux carriers determine the direction of this auxin flow through their asymmetric placement on the plasma membrane (PM).

Natural history collections provide invaluable sources for researchers with different disciplinary backgrounds, aspiring to study the geographical distribution of flora and fauna across the globe as well as other evolutionary processes.

In this thesis, bioorthogonal chemistry is combined with correlative light-electron microscopy to selectively label and study pathogenic intracellular bacteria within the host immune cell.

In this thesis, the research focuses on the properties of dark matter and dark matter haloes and how they connect with the galaxies we can observe in the Universe.

Promotor: Prof.dr. E.F. van Dishoeck

Promotor: Prof.dr. B. van de Water