The chemical and structural heterogeneity of toxoid vaccines makes their analysis challenging. However, detailed insights on a molecular level can be obtained by mass spectrometry.

This dissertation focuses on developing new mathematical and statistical methods to properly represent time-varying covariates and model them within the context of time-to-event analysis.

Understanding how galaxies form, interact, and evolve comes largely from comparing theory predictions with observational data. Numerical simulations of galaxies provide the most accurate approach to testing the theory, as they follow the non-linear evolution of gas and dark matter in great detail and…

In het onderwijs bieden wij alle studenten de mogelijkheid om kennis te maken met duurzaamheidsthema’s en –vraagstukken, waar mogelijk aansluitend bij de inhoud van hun opleiding.

Cardiovascular syndromes are the major cause of death in Western societies.

Cardiovascular disease is the number one cause of death worldwide. The most important risk factor for developing this disease is high cholesterol levels in the blood.

Sepsis is a life-threatening condition caused by a dysregulated host response to infection, it is associated with significant morbidity, mortality, and with a high financial burden on global healthcare systems. Bacterial infections are the primary cause of sepsis, but the growing prevalence of antimicrobial…

Promotor: Prof.dr. J.N. Kok, Co-promotor: A.J. Knobbe

We find ourselves in an era of transition, not just towards a more computing- and data-driven society but also away from unsustainable fossil fuels as an energy source.

The focus of this thesis is how stars like our Sun and planets like Jupiter, Saturn, and Earth are formed.

Promotor: Prof.dr. G.P. van Wezel

The increasing competition in the automotive industry requires the tailored, swift development of technologically sophisticated vehicles. Therefore, the computationally expensive state-of-the-art simulation technologies are combined with optimization algorithms. An example of a real-world optimization…

Deze LTA Teaching Fellows ontwikkelen onderwijs waarmee studenten kun academische vaardigheden kunnen vergroten.

Promotor: M. Danhof, Co-promotor: E.C.M. de Lange

Promotores: T. Hankemeier; R. Berger, Co-promotor: R.J. Vreeken

Promotor: J. Aarts

In today's volatile market environments, companies must be able to continuously innovate. In this context, innovation does not only refer to the development of new products or business models but often also affects the entire organization, which has to transform its structures, processes, and ways of…

Streptomyces present a valuable platform for natural product discovery. Lugdunomycin is a novel angucycline-derived polyketide from Streptomyces sp QL37, with unprecedented skeleton and antimicrobial activity.

The main goal of the research described in this thesis was the development of new photoactivated chemotherapy (PACT) ruthenium(II) complexes bearing a non-toxic photolabile ligand.

One of the main challenges in the development of an effective anti-cancer vaccine is the generation of an adequate and directed cellular immune response.

In this thesis, the focus lies on studying glucocorticoid receptor dynamics in living cells with the aim of understanding how this transcription factor finds its DNA target sites to regulate transcription.

Traditional drug discovery approaches have been hampered by (in vitro) cell-culture models that poorly represent the situation in the human body.

The effective treatment of tuberculosis (TB) remains a major challenge to global health.

The spindle-assembly checkpoint (SAC) is a safety mechanism which secures accurate chromosome segregation during mitosis.

Biopolymer sequencing with graphene edge-based tunnel junctions has the potential to overcome current limitations with the third generation of sequencing based on biological nanopores.

De programmagroep Onderwijswetenschappen verzorgt onderwijs op het gebied van onderwijs, het leren en de ontwikkeling van leerlingen in de schoolcontext. Studenten worden aangemoedigd uitkomsten van wetenschappelijk onderzoek te gebruiken om hun mening over het onderwijsbeleid en de onderwijspraktijk…

Viral hemorrhagic fever (VHF) is a group of acute diseases caused by highly infectious viruses including Ebola, Lassa, Dengue viruses. Its high mortality rate poses high risk to public health, however, studies on VHF have been hampered due to the non-availability of proper models and incomplete knowledge…

Humans and songbirds learn their vocalizations early in life by exposure to the vocalizations of adult conspecifics. Often, better learning outcomes are achieved with live, social, tutors than with audio-only exposure to vocalizations.

This thesis utilises the exceptional sensitivity and resolution of LOFAR to explore the low-frequency Universe, while simultaneously advancing the telescope's capabilities to enable new scientific discovery.

Promotors: C.A.J. Knibbe, Anthonius de Boer, Co-promotor: M.M.J. van der Vorst

Streptomyces are prolific producers of enzymes and secondary metabolites, including more than 50% of all clinical antibiotics. This makes them highly attractive for medical, biotechnological, and industrial purposes.

Promotor: G.P. van Wezel, Co-promotor: D. Claessen

This thesis investigates a pharmacological challenge model induced by Toll-like receptor 7 (TLR7) activation, focusing on skin inflammation and its implications for early drug development.

Inflammatory skin diseases such as psoriasis and atopic dermatitis can severely impact both the physical and social aspect of a patient’s life. Aberrant inflammatory responses are thought to be a major causative factor in these disorders, but an abundance of different factors contribute to the development…

Wat zijn de beste werkwijzen om studenten te leren omgaan met complexe problemen?

Lees meer over informatieve activiteiten voor de MSc International Politics aan Universiteit Leiden, zoals webinars, online Q&A-sessies en evenementen voor toekomstige studenten.

Ben jij benieuwd waarom mensen zijn zoals ze zijn – en hoe ze veranderen? Bij de Universiteit Leiden duik je in maatschappelijk gedrag, ideeën en culturen, van vroeger tot nu en van lokaal tot wereldwijd. Van grote steden tot wereldreligies, van filosofische vragen tot opvoeding en onderwijs – je onderzoekt…

Ontdek de inhoud van de éénjarige MSc Nederlandse Politiek aan Universiteit Leiden: kernvakken, keuzevakken, scriptie en analytische vaardigheden binnen kleinschalig onderwijs.

Lees meer over de MSc International Politics aan Universiteit Leiden: programma-opbouw, kernvakken, thesis-seminar en kleinschalige begeleiding in Den Haag.

Lees meer over voorlichtingsactiviteiten voor de MSc International Organisation aan Universiteit Leiden, zoals webinars, virtuele sessies en Q&A’s over de aanmelding.

Striga hermonthica, commonly known as witchweed, infests major cereal crops in Sub-Saharan Africa causing severe yield losses and threatening the livelihood of millions of resource poor farmers.

This work describes the use of click-to-release chemistry to get spatiotemporal control over immunocytokine activity. Until now, immunocytokines (cytokines coupled to a tumor-targeting-moiety) remained active throughout the body, being able to bind their respective receptors, causing mild to severe…

Ons bacheloronderwijs sluit nog niet altijd goed aan bij het niveau van onze master-opleidingen. Dit team zal uitwerken hoe deze aansluiting beter kan warden en hoe het afstudeertraject hierin een rol kan spelen.

The stratum corneum is the outermost skin layer and consists of dead cells embedded in a lipid matrix.

Promotoren: Prof.dr. G.R. de Snoo en Dr. R. Heijungs

The lipid membrane is a basic structural component of all living cells. Embedded in this nanometer-thin barrier, membrane proteins shape the membrane and at the same time respond to the shape of the membrane.

Consequences for sediment stability and seston trapping

The deeper understanding of an organism's pathology is important for developing treatments. Over centuries of systematic research, clinical researchers have demonstrated that the more information they acquire about the cellular properties and their organisation in the tissue, the better they can understand…

Met het afronden van je bachelor zet je een belangrijke stap. Maar daarmee is je academische vorming nog niet helemaal ‘af’. Veel opleidingen en banen vragen om meer. Daarom stimuleert de Universiteit Leiden je om na je bacheloropleiding door te gaan met de masteropleiding. Jouw Leidse bachelordiploma…

This thesis describes the development and validation of new high-contrast imaging techniques, with the ultimate goal of enabling the next generation of instruments for ELT-class telescopes to directly image Earth-like extra-solar planets orbiting around nearby stars.