This thesis presents pioneering work on the panchromatic emission of some of the most luminous galaxies in the early Universe: star forming galaxies and active galactic nuclei.

Stellar feedback is a crucial ingredient in the evolution of galaxies.

Promotor: Prof.dr. K.H. Kuijken, Co-Promotor: H.Hoekstra

Promotor: Prof.dr. A.W. van der Vaart

Promotores: B. van de Water; P. Hogendoorn; J. Bovée Co-Promotor: E.H.J. Danen

A common method to solve expensive function evaluation problem is using Bayesian Global Optimization, instead of Evolutionary Algorithms.

De beschrijvende taalkunde aan het LUCL omvat de documentatie en de beschrijvende analyses van minder-bestudeerde talen en de typologische en historische vergelijkingen tussen talen.

Cardiovascular disease is the number one cause of death worldwide. The most important risk factor for developing this disease is high cholesterol levels in the blood.

Promotor: Prof.dr. A. Doelman, Co-promotor: V. Rottschäfer

Promotor: H.P. Spaink, Co-Promotor: A.H. Meijer

In this Yearbook you will find some fascinating examples of what was done in 2021, not only by ourselves, but also by our international colleagues.

This dissertation focuses on developing new mathematical and statistical methods to properly represent time-varying covariates and model them within the context of time-to-event analysis.

We find ourselves in an era of transition, not just towards a more computing- and data-driven society but also away from unsustainable fossil fuels as an energy source.

This thesis advances our understanding of lipid uptake, a vital first step in lipid metabolism, by developing innovative click chemistry-based tools to study how immune cells internalize lipids.

Every organisms in the tree of life faces the same challenge: the length of its DNA exceeds the volume of the cell it needs to fit in. Several strategies have evolved to solve this problem, one of them being the expression of proteins that bind and organize the DNA.

Electrocatalysis allows for storing electricity or converting it into chemical bonds, producing chemical building blocks and fuels using renewable resources.

Of all the mass in our Universe, 80% is thought to consist of a hypothetical and invisible substance called dark matter (DM).

Overall dispersion in LCA as result of inherent uncertainties, spread and unrepresentativeness.

Promotores: J.A.van Veen, P.L.G.Klinkhamer. Co-promotor: E.E.Kuramae

The growing demand of energy indicates that global energy resources in the form of fossil fuels will not be sufficient in the future. In order to solve potential future energy problems development of a sustainable hydrogen economy is highly desirable.

This Thesis focuses on the design and synthesis of ADP-ribosylated compounds that can be applied in biological studies.

Op 11 november 2021 verdedigde Mariana Gkliati het proefschrift 'Systemic Accountability of the European Border and Coast Guard'. Het promotieonderzoek is begeleid door promotoren prof.dr. P. Rodrigues en prof.dr. L. Besselink (UvA).

To contribute to the body of knowledge aiming at a better coverage of ecosystem service assessment in LCA studies, this thesis dives into the challenges of incorporating existing ecosystem service methods within the impact assessment phase of the conventional LCA framework.

This research delves into a region of space known as the interstellar medium (ISM), which is essentially the area between the stars filled with gas and dust.

Promotores: H.A. Udo De Haes, P.M. Brakefield

The long-held desire - to link structure directly to function and to explain molecular mechanisms based on basic chemical or physical principles - is finally coming closer, satisfying not only our scientific curiosity but also offering new solutions to the many challenges in the field of health, energy…

Promotor: F.P. Israel, Co-Promoter: R. Meijerink

Taking as a point of departure the Italian American community in Boston and its process of collective remembrance surrounding Saint Anthony’s Feast, we addressing the limits and potential of montage.

Surface acoustic waves (SAWs) are mechanical waves that travel along the surface of a material and find many applications in modern technologies due to the ease of excitation on piezoelectric substrates via interdigital transducers (IDTs).

Het documenteren en beschrijven van de talen van de wereld.

Artful Mathematics: The Heritage of M. C. Escher

Breast cancer is the most common cancer in women worldwide. Metastasis, the process by which cancer cells spread to other parts of the body, makes treatments less effective. It is important to unravel the mechanism of metastasis.

This thesis addresses the problem of designing performance and energy efficient embedded streaming systems, that is, systems which process a stream of input data coming from the environment and generate a stream of output data going into the environment.

The applications of studying the early development of insects range from agriculture to material science.

On the largest scale, the Universe resembles a cosmic spiderweb. Most galaxies coexist in small groups within the threads of this web. At the nodes of the threads are enormous groups of galaxies forming the largest structures in the universe still held together by gravity: clusters of galaxies.

Promotores: Prof.dr. J.N. Kok, Prof.dr. C.A. Mandemakers, Co-Promotor: G. Bloothooft

Promotores: Prof.dr. W.J.G.M. Peijnenburg & Dr. M.G. Vijver

Promotor: R. Verpoorte, Co-promotores: Y.H.Choi, N.R. Mustafa

Shape and biological function are tightly connected. Physical descriptions are used to connect the shape of a biological system with its function.

Promotores: Prof.dr. G.A. van der Marel, M. van Heel

Phosphorylation affects all four major biomolecules – proteins, lipids, carbohydrates and nucleic acids – and plays a pivotal role in the most fundamental cellular functions.

Innovation plays an essential role in firms' competitiveness and long-term success. It varies from different types, ranging from run-of-the-mill innovation that brings incremental changes to existing technologies to radical innovation that breaks from existing trajectories.

During embryonic growth, cells proliferate, differentiate, and collectively migrate to form different tissues at the right position and time in the body.

Promotores: T.H. Oosterkamp, N. de Jonge

At the largest scales, two ingredients dictate the distribution of matter in the Universe. The first is dark matter, acting as an invisible scaffolding held together by gravitational forces.

Traditionally, vaccines are administered intramuscularly using conventional hypodermic needles, which cause pain and distress. Microneedles are very short needles (smaller than 1 mm) that are practically invisible to the naked eye.

This thesis examines enzyme domain architecture and engineering to improve the breakdown of lignocellulose and starch, abundant biopolymers crucial for sustainable biofuel and biochemical production. Carbohydrate-active enzymes (CAZymes) facilitate this degradation, but the structural complexity of…

Op 17 november 2021 verdedigde Cyril-Igor Grigorieff het proefschrift 'The Regime for International Air Carrier Liability'. Het promotieonderzoek is begeleid door prof.dr. P. Mendes de Leon en prof.dr. V. Correia (University Paris Saclay).

Despite being the object of intense study, embryonic development has been difficult to model due to a number of reasons. First, complex tissues can be comprised of many cell types, of which we probably only know a subset.