Dissochaeta Blume (Melastomataceae, tribe Dissochaeteae) is well-known as a scrambling plant genus found in Southeast Asia, where it is an inhabitant of the tropical rainforests or evergreen forests.

Studievoorlichting

The overarching clinical aim of this thesis was to improve pharmacological pain management by characterizing the pharmacodynamics of analgesics. This promotion has been awarded the predicate cum laude.

Transplantation of labial salivary glands to the eyelids for patients with dry eye appears to give excellent results clinically.

Large parts of the research described in this Thesis aims at the development of oligopeptide-masked toxins and their in situ immunoproteasome-mediated activation.

The power of personalized nutrition lies in being able to conduct clinical research on healthy people while capturing metabolic markers sensitive to the impact of environmental and metabolic stressors (e.g. diet, changing sex hormones and the menstrual cycle).

Studievoorlichting

Studievoorlichting

De sectie Gezondheids-, Medische en Neuropsychologie verzorgt onderwijs in de bachelor- en masterfase.

Science is typically a patchwork of research contributions without much coordination. Especially in clinical trials, the follow-up studies that we do fail to be the most promising.

Dit stappenplan geeft je de nodige hulp en begeleiding bij het indienen van je aanmelding voor de masterspecialisatie Klinische Psychologie aan de Universiteit Leiden.

Mycorrhizas are symbiotic associations between soil fungi and most plant species.

Anthropogenic noise negatively affects wildlife in a wide range of taxonomic groups.

This thesis focuses on important life history traits and their trade-offs using two hexapod models. Particularly, the trade-off between immune defense and embryonic developmental speed is a central theme of this study.

Human vocal communication and music perception represent advanced cognitive skills, seemingly innate and universal. These faculties encompass a range of perceptual and cognitive abilities. Cross-species research sheds light on the origins of musicality by investigating whether these traits are shared…

Organisms often need to adapt more efficiently and devise new strategies for surviving difficult ecological circumstances.

Promotor: C.J. ten Cate

In my research, I used a comparative wood anatomical approach to address wood evolution of the (largely) tropical flowering plant families Apocynaceae and Sapotaceae.

All crested and marbled newts (the genus Triturus) suffer from an unusual genetic abnormality, called a balanced lethal system, that kills exactly half of their offspring. How can a trait so disadvantageous have survived millions of years of natural selection?

Promotor: M. Danhof Co-promotor: O.E. Della Pasqua

The main objective of this thesis was to develop clinically relevant survival models for patients with high-grade soft tissue sarcoma of the extremities, in particular the development and validation of prediction models for use in clinical practice.

De Universiteit Leiden stimuleert studenten om na hun bacheloropleiding door te gaan met de masteropleiding. Je Leidse bachelordiploma Psychologie geeft je toegang tot de masteropleiding Psychologie in Leiden.

Clinical development of drugs for central nervous system (CNS) disorders has been particularly challenging and still suffers from high attrition rates.

The deeper understanding of an organism's pathology is important for developing treatments. Over centuries of systematic research, clinical researchers have demonstrated that the more information they acquire about the cellular properties and their organisation in the tissue, the better they can understand…

The zebrafish is a promising vertebrate model organism in early drug discovery and development.

Promotie

Plant exudates appeared long time ago in the history line of life in the early Devonian. They are typical saps produced by specialized cells.

Promotor: Prof.dr. P.G.L Klinkhamer, Co-promotor: K. Vrieling

In this thesis, I targeted the orchid genus Lepanthes, one of the six genera of angiosperms that surpasses 1,000 species in the Neotropics, as a study model to investigate the evolutionary processes that promoted species diversifications.

Breeding for resistance becomes more and more important because we want to reduce the use of pesticides. A fast and cheap alternative can be to make use of morphological or chemical markers.

Hieronder vind je de antwoorden op een aantal veelgestelde vragen over toelating tot de klinische specialisaties van de Master Psychologie.

This dissertation focuses on developing new mathematical and statistical methods to properly represent time-varying covariates and model them within the context of time-to-event analysis.

Explaining treatment response variability between and within patients can support treatment and dosing optimization, to improve treatment of individual patients.

Binnen de sectie Gezondheids-, Medische en Neuropsychologie wordt onderwijs verzorgd en onderzoek verricht op verwante deelgebieden van de psychologie: Gezondheids-, Medische en Neuropsychologie.

Drug-induced liver injury (DILI) is one of the main reasons for drug attrition during pre-clinical and clinical phases of drug development as well as for drug withdrawal post-marketing.

Inactivating mutations in BRCA1 or BRCA2 genes predispose to several types of cancer.

Promotores: J. Jonkers, K.E. de Visser

Atherosclerosis is a progressive disease resulting in the formation of an arterial plaque. Despite lipid lowering, recurrent cardiovascular events remain a risk. While atherosclerosis is primarily lipid-driven, the immune system plays a critical role in the pathophysiology.

In the last decades, activity-based protein profiling (ABPP) has emerged as a powerful chemical tool that may aid the ever-challenging drug discovery process.

Promotor: C.A.J. Knibbe, Co-promotor: J.J. Boelens, R.G.M. Bredius

Statistical considerations guide the design and implementation of the experiments that scientists perform. For instance, in a clinical trial about a the efficacy of a treatment, its effect in a certain minimum amount of patients has to be observed in order to make confident assertions about the efficacy…

Less than 1 in 10 drug candidates that enter phase 1 clinical trials actually gets approved for human use.

The clinical potential of applying synthetic lethality to cancer treatment is famously demonstrated by the BRCA1/PARP1 paradigm: a tumor specific defect in BRCA1 – a component of the DNA double-strand break (DSB) repair pathway homologous recombination (HR) – results in a remarkable sensitivity to PARP1…

There is an urgent need for more physiologically relevant cell culture methods to guide compound selection in pre-clinical stages of the drug development pipeline.

The major and ultimate aim of metabolomics is to obtain an answer to a specific biological or clinical question.

Triple-negative breast cancer (TNBC) is a subtype of breast cancer characterized by limited treatment options and unfavorable clinical outcomes. Therefore, the research described in this thesis focused on the exploration of novel targeted therapies for TNBC.

Promotie