This dissertation was to develop effective graphene-based nanofluidic devices by developing scalable fabrication methods and elucidating proton transport mechanisms.

Molecular complexes can be used as electrocatalysts for oxygen reduction, water oxidation, and/or hydrogen peroxide production.

Promotores: Prof.dr. W.J.G.M. Peijnenburg & Dr. M.G. Vijver

With an emphasis on developing novel miktoarm star polymers termed PeptoMiktoStars, this thesis leverages asymmetric polymeric polypept(o)ide frameworks to advance their effectiveness in delivering hydrophobic drugs and nucleic acids.

The aim of this thesis was to study phage infection in Streptomyces, focused on cell wall-deficient cells. Bacteriophages (or phages in short) attach to the cell wall of bacteria after which they replicate and lyse the host cell.

This thesis explored the molecular pharmacological mechanisms of targeting CB2R via investigation of novel drug discovery concepts such as target binding kinetics, allosteric modulation and biased signaling.

This work has described synthetic strategies towards well-defined structures resembling capsular polysaccharide (CPS) fragments, CPS mimics, teichoic acid (TA) fragments as well as a third-generation ring-closing tandem metathesis (RCM) linker to better exploit the potential of automated synthesis.

N-acylethanolamines (NAEs), including N-arachidonoylethanolamine (anandamide, AEA), N-palmitoylethanolamine (PEA) and N-oleoylethanolamine (OEA), are signaling lipids that play an important role in different physiological process.

Data Science (DS) and Artificial Intelligence (AI) are omni-present and have the potential to be incorporated in various fields. However, in order to live up to this expectation, a good understanding of the techniques, their implications and limitations is required. In this minor you develop insights…

Hieronder vind je een overzicht van de publicaties van LAPP.

Het Instituut Bestuurskunde is gevestigd in Den Haag.

Mensenrechten zijn lang het unieke domein van staten geweest. Dat is veranderd met de globalisering en de opkomst van multinationale ondernemingen. De zorg voor fundamentele arbeidsrechten binnen mondiale toeleveringsketens vormt een probleem.

Promotor: H.J.M. de Groot

Grensverleggend geschiedenis leren.

This thesis presents the results of a study on the interfaces of insulating oxides with and without the insertion of a magnetic layer.

Atoms and molecules are the basic units of matter. If we keep dividing a bar of gold or a glass of water into smaller parts, at the end we are left with a single gold atom or a water molecule.

To contribute to the body of knowledge aiming at a better coverage of ecosystem service assessment in LCA studies, this thesis dives into the challenges of incorporating existing ecosystem service methods within the impact assessment phase of the conventional LCA framework.

Promotor: Prof.dr. E.F. van Dishoeck, Co-Promotor: M.R. Hogerheijde

Promotor: A. Achúcarro, Co-promotor: A. Boyarsky

The expedition commanded by Nicolas Baudin to Tenerife, Mauritius, Australia, Timor and South Africa in 1800-1804 is fully researched in regard to ornithology.

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

This thesis is about augmented reality (AR). AR is commonly considered a technology that integrates virtual images into a user’s view of the real world.

Single-molecule spectroscopy has become a powerful method for using organic fluorescent molecules in numerous applications.

The effects of anthropogenic noise on interactions between predators and their prey are still little understood.

This dissertation is about Bayesian learning from data. How can humans and computers learn from data?

Healthy aging is one of the prime goals in today's society and atherosclerosis is among the greatest causes of morbidity in elderly. Cardiovascular disease patients receiving treatment are often of advanced aged and have an aged immune system, which limits translating experimental findings to the pa…

Throughout the history of computer science, a major challenge has been how to assert that software is free of bugs and works as intended. Software bugs can lead to serious negative impacts on any software system. Throughout the main body of the thesis, we implemented a series of studies on exploring…

Neurodegenerative diseases pose a large medical and societal challenge. The etiology of these diseases is still poorly understood, which makes drug discovery for these diseases difficult.

Promotor: Jelle S. Kaastra Co-promotor: Jelle de Plaa

The transition to electric vehicles (EVs) reduces vehicle emissions to combat climate change. EVs raise concerns regarding the production of lithium-ion batteries and related emissions; while batteries can also provide energy storage services for the electricity system.

My PhD project studies how the temporally sequential Hox gene expression is regulated during head-tail patterning of the frog embryo.

The energy system is at the heart of two of the greatest challenges of the 21st century: decreasing CO2 emissions to meet the ambitions of the Paris agreement while fulfilling the growing energy demand associated with the economic aspirations of a growing world population.

Solute carrier (SLC) transporters are a large and diverse class of relatively understudied transmembrane proteins.

Solar energy is used by photosynthetic organisms to drive energy required cellular processes. Is absorbed by two groups of pigments, located in the LHCs.

Promotor: Prof.dr. G.R. de Snoo, Prof.dr. G.A. Persoon, Co-promotor: H.H. de Iongh

Pharmaceutical companies, governments and the general public have become increasingly aware that animal models used in drug testing lack vital aspects to serve as an accurate representation of human biology. As models of the human body should become more physiologically relevant, animal models no longer…

The ongoing increase in antimicrobial resistance combined with the low discovery of novel antibiotics is a serious threat to our health care.

Promotor: Prof.dr. R. Verpoorte, Co-Promotores: N.R. Mustafa, A.E. Schulte

This thesis is devoted to an in-depth examination of the various effects of disorder in the cuprate high-temperature superconductors.

Control of infectious diseases poses continuous challenges for human health.

Promotores: S.F. Portegies Zwart, E. M. Rossi

Growth and development affect the metabolism of drugs administered to neonates, infants, and children.

Promotor: J.S. Kaastra Co-promotor: E. Constantini

Promotor: M.K. Richardson, Co-Promotor: F. Witte

The effective treatment of tuberculosis (TB) remains a major challenge to global health.

Promotores: F.H. van Lunteren, F.P. Israel

Glycosidases are essential in fundamental biological processes and are responsible for the degradation of most (oligo)saccharides, glycolipids and glycoproteins.

This thesis systematically analyzes the physical-chemistry of lipid-graphene interactions with the major objective of reconciliating the variety of results reported in the literature.