Errors are everywhere, and mechanical failures are especially common: buckled grain silos and cracked support columns are, justly, seen as an issue to be avoided.

This thesis focuses on amyloid proteins, a class of proteins that convert into amyloid fibrils.

One of the major limitations in culturing complex tissues or organs is the lack of vascularization in the cultured tissue. Development of a functional capillary bed could overcome this problem.

Kunst en vrije tijd, Kunst en vrije tijd

Promotor: Prof.dr. H.P. Spaink, Co-promotor: Prof.dr. A.H. Meijer

Het onderzoek binnen de Faculteit der Wiskunde en Natuurwetenschappen omvat de disciplines wiskunde, informatica, sterrenkunde, natuurkunde, scheikunde, bio-farmaceutische wetenschappen, biologie en milieuwetenschappen.

De Nationale Politie kan volgend jaar mogelijk rekenen op 300 miljoen euro extra. Bart Custers, hoogleraar Law and Data Science, sprak met EenVandaag over de mogelijkheden om AI in te zetten in de werkprocessen van de politie.

Studievoorlichting

Studievoorlichting

Atoms and molecules are the basic units of matter. If we keep dividing a bar of gold or a glass of water into smaller parts, at the end we are left with a single gold atom or a water molecule.

This dissertation revolves around the design and implementation of novel instrumentation and related measurement techniques, at the single molecule level, for use in biophysical research. Chapter 1 presents an introduction to the field of fluorescence-based single molecule measurements. In particular,…

Graphene nanoribbons (GNRs) are used as a current carrying substrate in investigation of current-induced forces in a low-temperature STM (chapter 2).

Death in all types of melanomas is generally caused by metastasis. Uveal melanoma (UM) is the most common intraocular melanoma, there are currently no (patient-derived) animal models that faithfully recapitulate metastatic dissemination of UM.

Taxonomy as a science has accumulated data and knowledge for more than 250 years.

Bacteria have the ability to alter their morphology in order to adapt to changing environments.

Mechanical metamaterials are carefully engineered materials whose properties are controlled by their structure, not by their composition, which allows using metamaterials to study and control physical effects in detail⁠.

The explosive radiation and diversification of the advanced snakes (superfamily Colubroidea) was associated with changes in all aspects of the shared venom system. Morphological changes included the partitioning of the mixed ancestral glands into two discrete glands devoted for production of venom ormucous…

Promotores: Prof.dr. H Lenstra, Prof.dr. A Facchini (Padova University)

Glucocorticoids are potent anti-inflammatory drugs widely used clinically to treat various inflammatory and immune conditions. However, two main clinical problems limit their use. GCs trigger severe side effects and they induce acquired glucocorticoid resistance, especially during chronic systemic treatment…

Green hydrogen is produced via a process called water electrolysis. During electrolysis water is split into oxygen and hydrogen.

The overall theme of this thesis is to complement the electrochemical data acquired in fuel cell research with in situ X-ray photoelectron spectroscopy (XPS) and soft X-ray absorption spectroscopy (XAS).

The specialisation Science Communication and Society (SCS) concerns science communication in a broad sense. The program focuses on the link between science and society and covers knowledge and skills in the field of science communication.

The transition to electric vehicles (EVs) reduces vehicle emissions to combat climate change. EVs raise concerns regarding the production of lithium-ion batteries and related emissions; while batteries can also provide energy storage services for the electricity system.

Promotor: H.J. van den Herik, B.R. Katzy, Co-promotor: K. Sailer

Prof.dr. J. Memelink

Het Leiden Leadership Centre doet onderzoek naar de ontwikkeling van doeltreffend publiek leiderschap binnen en tussen organisaties. Op basis van onze onderzoeks- en ontwikkelagenda “Verder met Publiek Leiderschap” richten we ons op publiek leiderschap in verbinding met de publieke context, maatschappelijke…

Plants, are sessile organisms, have developed strategies to adapt to changes in their environment, in part by altering their growth and development.

Pseudomonas Aeruginosa is a Gram-negative bacterium which can form biofilms, increasing its resistance against antibiotics and the host immune system. Polysaccharides are an integral part of this biofilm, one of these polysaccharides is called Psl. PslG is a glycosidase, able to cleave this polysaccharide,…

Het Leiden Leadership Centre is een internationale en interdisciplinaire netwerkorganisatie. In onze aanpak brengen we mensen met verschillende achtergronden en diverse perspectieven samen

Viral hemorrhagic fever (VHF) is a group of acute diseases caused by highly infectious viruses including Ebola, Lassa, Dengue viruses. Its high mortality rate poses high risk to public health, however, studies on VHF have been hampered due to the non-availability of proper models and incomplete knowledge…

Bacterial chemosensory arrays are protein assemblies that are the key structural and functional component for motile bacteria to sense their internal or environmental chemical signals.

This PhD-thesis presents a study on micron-sized particles, so-called colloids. By controlling the chemical and physical properties of these particles, such as the interparticle interaction and the particles’ shape, colloids can act as building blocks that self-assembly into larger structures.

Mining time series is a machine learning subfield that focuses on a particular data structure, where variables are measured over (short or long) periods of time.

During post-embryonic development into adults, animals face an environment that fluctuates constantly. For example, in nutrient availability, temperature, and osmolarity (e.g., salt concentration).

Shape and biological function are tightly connected. Physical descriptions are used to connect the shape of a biological system with its function.

Cardiovascular diseases (CVDs) are the leading global cause of mortality. Endothelial dysfunction, an early reversible stage of CVD development, is marked by decreased nitric oxide production linked to Ca2+ influx in endothelial cells.

The plant hormone auxin plays a central role in the growth and development of plants. Auxin acts in a concentration dependent manner and polar cell-to-cell transport of this hormone determines its distribution in the tissues of plants. This polar auxin transport is mediated by several families of auxin…

In this PhD-thesis several new and existing data science application are described that are particularly focused on applications for tax administrations.

This thesis focuses on using liposomes in two different treatment strategies; vaccination (or immunotherapy) and delivery of a small molecule, and in two different disease models; cancer and atherosclerosis.

Plants are colonized by an astounding number of microorganisms that can provide different life-support functions, including nutrient acquisition and protection against (a)biotic stresses like drought or pathogen attack.

This thesis explores how electron paramagnetic resonance (EPR) spectroscopy can be used to investigate key biochemical processes.

The filamentous bacteria Streptomyces are widespread inhabitants of terrestrial soils.

Promotor: Prof.dr. J.G.E.M. Fraaije, Co-promotor: A. Kros

In 2019 startte LUGO een petitie met het verzoek om een ambitieuze duurzaamheidsvisie voor 2030. Deze petitie is geformuleerd op basis van wat LUGO haalbaar achtte in plaats van op de beperkingen van nu. Wij vinden dat duurzaamheid een van de kernwaarden moet zijn van het volgende centrale beleidsplan…

Streptomyces are bacteria abundant in soil that participate in diverse and complex interactions. These bacteria are the main producers of the antibiotics we currently use in the clinic.

Aspergillus niger is an important industrial producer of organic acids and enzymes producing large amounts of spent fungal biomass.

Empirical Legal Studies in Leiden focuste op het bouwen van een interdisciplinaire gemeenschap van rechtsgeleerden en sociale wetenschappers die samen juridische vraagstukken onderzochten op het snijpunt van recht en gedrag, waarbij diverse soorten methoden werden gebruikt.

Thermodynamics is one of the founding scientific pillars that has helped us better understand heat engines, biology, ecosystems, and even black holes. While it fundamentally describes large systems by examining the bulk behavior of their constituents, it is anchored in the statistical equivalence of…

Leidse wetenschappers onderzoeken de wereld om ons heen en geven hun kennis door aan toekomstige generaties. Zij geven gezicht aan de universiteit, ieder met zijn of haar individuele expertise en persoonlijke fascinatie voor het eigen vakgebied.

The thesis addresses the long-term dynamical evolution of hierarchical multiple systems.