The research described in this thesis shows that hypercholesterolemia, a well-established risk factor for atherosclerosis, can impact skin lipid pool and barrier function already at young age. In the field of atherosclerosis, we showed that the small peptide Lyp-1 can be used as a targeting molecule…

Nanodiscs are small, disc-shaped structures designed to mimic biological cell membranes, composed of a lipid bilayer stabilized by scaffold proteins. Membrane proteins play crucial roles in essential processes such as nutrient and waste transport, molecular recognition, and cell signalling, making them…

The genetic information of all living organisms is contained in their DNA. Cells modify the degree of DNA compaction by epigenetics, which largely determines what genes are read out and which genes are transcriptionally silent.

Hoe gebruiken ziekteverwekkende mycobacteriën de vetten in onze cellen, en hoe kunnen we dat tegenhouden?

This thesis introduces the concept of

Tuberculosis is a major global health problem caused by the Mycobacterium tuberculosis complex, claiming more than a million lives annually.

Herken je dat: je ziet je vriend lachen, en plots begin je ook te grijnzen? Promovendus Chris Riddell doet onderzoek naar hoe en waarom we lichaamstaal kopiëren. Hij neemt je als nieuwe Face of Science een jaar lang mee in zijn onderzoek.

Promotor: A. Kros, Co-promotor: R.R.C.L. Olsthoorn

Cholesterol influences many pathways, including serving as precursor for adrenal steroidogenesis. Imbalance of cholesterol levels has been implicated in several diseases including cardiovascular diseases and its underlying pathology, atherosclerosis.

Het is onderzoekers voor het eerst gelukt grafeen op een stabiele laag vetten, ofwel lipiden, te plaatsen. Omringd door een beschermende laag van lipiden zou grafeen in het lichaam als een veelzijdige sensor kunnen dienen. De resultaten zijn de eerste stap naar zo’n omhulsel en zijn op 28 september…

In this thesis I highlight the applications of Oxford Nanopore Technologies (ONT) sequencing. This technique is a relatively new approach in the sequencing field, where nanopores are embedded in a membrane, DNA molecules are pulled through nanopores and an electrical current serving as the sequencing…

Tijdens hackwedstrijd HALON hadden 28 teams één doel: zoveel mogelijk kwetsbaarheden vinden in de systemen van Nederlandse hogeronderwijsinstellingen. Ontwikkelaar onderwijssoftware Chris Handy deed in zijn eentje mee en belandde op de tweede plek in de categorie ‘Vulnerabilities found at the highest…

Promotor: A. Kros

Heart failure is a major health care problem with high mortality.

The PID-directed shift in PIN polarity has been broadly accepted as one of the essential mechanisms for the regulation of auxin transport polarity.

Preterm birth is a major contributor to neonatal morbidity and mortality and is associated with both acute complications and long-term health consequences.

The research described in this thesis combines the latest insights in lysosomal function with lysosome centred cell signalling.

Farmacoloog Walter Boiten ontwikkelde een nieuwe methode om de hoeveelheid vetten in iemands huid te kunnen bepalen. Met de methode testte hij de effecten van een nieuwe crème die hij ontwikkelde voor eczeempatiënten. De eerste resultaten zijn veelbelovend. Boiten promoveert op 15 januari.

The ideas underlying this thesis are that lipidomics may improve the diagnosis of liver metabolic diseases, and can provide further insights into the underlying pathophysiology of these diseases.

Shape and biological function are tightly connected. Physical descriptions are used to connect the shape of a biological system with its function.

Promotor: A. Kros

This thesis focuses on the study of transient and variable radio sources in the universe.

Promotor: M.A.G.J. Orrit

Dit was het programma van De Kennisboomgaard 2025:

This thesis describes the development and optimization of the first molecular tools to study the enzyme PLA2G4E.

Advanced mass spectrometry of glycosphingolipids takes the central stage in this thesis. Investigations focus on characterization of glycosphingolipid metabolism in health and disease with emphasis to the detection and accurate quantitation of known and so far unknown glycosphingolipids and closely…

Cardiovascular diseases (CVDs) are the leading global cause of mortality. Endothelial dysfunction, an early reversible stage of CVD development, is marked by decreased nitric oxide production linked to Ca2+ influx in endothelial cells.

Inflammatory skin diseases such as psoriasis and atopic dermatitis can severely impact both the physical and social aspect of a patient’s life. Aberrant inflammatory responses are thought to be a major causative factor in these disorders, but an abundance of different factors contribute to the development…

Promotor: Prof.dr. E. Bouwman, Co-promotor: S. Bonnet

In this work, we attempt to answer the question:

Microbiome composition of the spermosphere and the rhizosphere of wild and modern bean accessions grown in an agricultural and a native soil from Colombia was characterized by metagenomics and cultivation-dependent approaches.

Promotor: Prof.dr. M.L. van Hecke, Co-Promotor: V. Vitelli

In most applications, electrocatalysts exhibit a large surface area to volume ratio, for example using nanoparticles.

Consequences for sediment stability and seston trapping

Plants and their pollinators form complex interaction networks. Within these networks, species differ widely in the number of species they interact with.

The four possible segments A, T, C and G that link together to form DNA molecules, and with their ordering encode genetic information, are not only different in name, but also in their physical and chemical properties.

Promotor: J.M. van Ruitenbeek, Co-Promotor: S.J. van der Molen

This thesis describes the design and synthesis of fragments of various cell wall carbohydrates of the Streptococcus species, including the branched Group B-specific antigen (GBC) of Group B Streptococcus, glycerol phosphate (GroP) modified group A carbohydrate (GAC), and the O-acetylated type 1 capsular…

Promotores: J.N. Kok, H.J. Hoogeboom

We explored how to morphologically classify well-resolved jetted radio-loud active galactic nuclei (RLAGN) in the LOw Frequency Array (LOFAR) Two-metre Sky Survey (LoTSS) using machine learning.

Promotor: S.J. Edixhoven, Co-promotor: R.S. de Jong

Promotores: T.H. Oosterkamp, N. de Jonge

For each living organism health is ensured by correct functioning of its cells. Cells therefore have elaborate methods for regulation of their proteins.

The aim of this thesis is to study cell-cell interactions and the development of an assay to explore and quantify the exchange of membrane compounds.

Op 20 februari 2019 verdedigde Chris van Oostrum zijn proefschrift 'Regres bij concernfinanciering'. Het promotieonderzoek is begeleid door promotor prof. mr. S.M. Bartman.