The use of N fertilizers has increased worldwide in the past century. While this increased input of N has increased food productivity, it has also contributed to decreases in biodiversity, soil quality and environmental health, including increases in greenhouse gas emissions.

With an emphasis on developing novel miktoarm star polymers termed PeptoMiktoStars, this thesis leverages asymmetric polymeric polypept(o)ide frameworks to advance their effectiveness in delivering hydrophobic drugs and nucleic acids.

If mankind wants to survive into the 22nd century, we will need to change the way we live drastically. The human impact on our planet is everywhere, we are changing the atmosphere, the oceans and the land, leading to global warming, climate change, loss of biodiversity and pervasive pollution. There…

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Membrane fusion is a vital process in living organisms and is mediated by zipper-like proteins.

This thesis describes the role of pollution, specifically neonicotinoid insecticides, as an actor of the ongoing biodiversity decline.

Promotores: H.S. Overkleeft, G.A. van der Marel, Co-promotor: B.I. Florea

A management strategy has been developed for field margins to reduce pesticide drift to non-target areas and to promote biodiversity on arable land. To this end, 3 and 6 m wide strips along the edges of winter wheat, sugar beet and potato crops have been left unsprayed with herbicides and insecticides…

The key characteristic of active matter is the motion of an emergent collection (such as a flock of birds), which is driven by the consumption of energy by its active components (i.e. individual birds).

Due to their central physiological roles in living organisms, retaining beta-glycosidases have been the subject of tremendous research efforts to examine their structure/function relation using numerous biophysical and biochemical approaches.

Particles are omnipresent in biopharmaceutical products. In protein-based therapeutics such particles are generally associated with impurities, either derived from the drug product itself (e.g. protein aggregates), or from extrinsic contaminations (e.g. cellulose fibers).

The lipid membrane is a basic structural component of all living cells. Embedded in this nanometer-thin barrier, membrane proteins shape the membrane and at the same time respond to the shape of the membrane.

De maandelijkse dosis onderzoeksinspiratie van Leiden Science, van onze medewerkers, voor onze medewerkers en alle andere nieuwsgierigen.

Promotor: Prof.dr. P. Stevenhagen

Freshwater is an important resource, but at a great risk of species decline due to habitat loss, pollution and over-exploitation, and invasive alien species.

For centuries astronomers studied the Universe by collecting light. Nowadays, we are living in times of great technological advancements, which allow us to explore our Universe in a new way - though gravitational wave radiation.

Self-assembly is an abundant process in nature and is vital to many processes in living organisms.

Promotor: Jan van der Greef; Co-promotors: Mei Wang; Eduard van Wijk

Natural vanilla flavor is one of the most important in the world. However, the cost of this flavor is expensive. Production of this flavor by alternative methods, could reduce the cost.

Although nanoparticles are extensively used in various applications like consumer products and have most probably entered the environment, little is known about the effects of these particles on living organisms.

The genetic information of all living organisms is contained in their DNA. Cells modify the degree of DNA compaction by epigenetics, which largely determines what genes are read out and which genes are transcriptionally silent.

In this thesis we explore machine and deep learning approaches that address keychallenges in high dimensional problem areas and also in improving accuracy in wellknown problems. In high dimensional contexts, we have focused on computational fluid dynamics (CFD) simulations.

Plants are colonized by an astounding number of microorganisms that can provide different life-support functions, including nutrient acquisition and protection against (a)biotic stresses like drought or pathogen attack.

The overarching goal of this thesis is to set the foundations, but also make the first essential steps towards establishing a comprehensive, mesoscopic, hydrodynamic theory of epithelial tissues. The stage is set by an exhaustive study of topological defects in passive p-atic liquid crystals, singularities…

In this thesis, the focus lies on studying glucocorticoid receptor dynamics in living cells with the aim of understanding how this transcription factor finds its DNA target sites to regulate transcription.

This collection of papers was compiled in celebration of the remarkable academic career of Professor Wil Roebroeks, who has established himself as one of Europe’s leading figures in Palaeolithic archaeology over the past three decades and founded the Human origins research group at Leiden University…

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Hoe meer we leren over een (neuro-)psychologische of lichamelijke aandoening en de hieraan gerelateerde gedragsfactoren, hoe beter we deze niet alleen kunnen signaleren, maar ook behandelen. Het is dus belangrijk dat recente inzichten over (neuro-)psychologische problemen en daaraan gerelateerde gedragsfactoren…

Promotor: A.H. Meijer, Co-promotor: B.E. Snaar-Jagalska

Als een nieuwe methode is ontwikkeld om een (neuro-)psychologische aandoening of hieraan gerelateerde gedragsfactoren te herkennen en te behandelen, kan deze nog niet direct in de klinische praktijk worden ingezet. Eerst moet de methode geëvalueerd worden, bij voorkeur in gerandomiseerde, gecontroleerde…

Miriam van de Kamp (1980) houdt zich als cultuursocioloog al jaren bezig met stedelijke vraagstukken. Zij schreef onderstaand boek als onderzoeker bij het Centre for Modern Urban Studies aan de Faculteit Governance and Global Affairs.

Soil is a home for an unbelievable diversity and abundance of microbial life that is essential for supporting life on our planet.

Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel

Urbanisation is steadily increasing with estimates expecting that 68% of the global population will live in cities by 2050. To accommodate the rural to urban transition, large quantities of land are transformed from natural to urban lands.

Learning about My meaningful Way through life and profession.