Promotor: F. Arbab, R. De Nicola, Co-Promotor: M. Tribastone

In this thesis, I investigated the neurogenetic properties of Neotropical bat species. Bats represent the second largest mammalian order (Chiroptera) in the world, with Neotropical bats constituting about 13% of the total number of bat species.

It researches (the possibilities for) the development of a set of principles and best practices for insolvency office holders by comparing multilateral treaties and soft law recommendations and national legislation within Europe.

De Faculteit Wiskunde en Natuurwetenschappen

Clinical development of drugs for central nervous system (CNS) disorders has been particularly challenging and still suffers from high attrition rates.

Promotor: Prof.dr. S. Haring

In human cells, a meter-long DNA is condensed inside a micrometer-sized cell nucleus. Simultaneously, the genetic code must remain accessible for its replication and transcription to functional proteins.

The work presented in this thesis is based on ALMA surveys of protoplanetary disks in three star-forming regions: Lupus, OMC-2, and NGC 2024.

Promotor: K. Kuijken, Co-Promotor: H. Hoekstra

DNA carries various forms of information. Out of these forms of information the most well-known is classical genetic information.

Ferritin is a spherical metalloprotein, capable of storing and releasing iron in a controllable way. It is composed of a protein shell of about 12 nm and within its cavity, iron is stored in a mineral form.

Promotor: Prof.dr. J.A. Bouwstra, Co-promotor: A. El Ghalbzouri

Transplantation of labial salivary glands to the eyelids for patients with dry eye appears to give excellent results clinically.

Whilst government’s ability to design ‘context-specific’ regional innovation policy is generally assumed to depend on the region’s decision-making power, the aim of this study is to investigate how regional government matters. In order to open up the black box of policy design, the study develops a…

Plant diversity is essential for us and our planet as it sustains the stability of our ecosystems, provides vital materials and food to us and supports many ecosystem services.

A modern ship design process is subject to a wide variety of constraints such as safety constraints, regulations, and physical constraints.

Prostate cancer (PCa) is one of the most prevalent cancer in males.

Inactivating mutations in BRCA1 or BRCA2 genes predispose to several types of cancer.

Promotor: Ed F. Deprettere, Co-promotor: Todor P. Stefanov

Onderzoek van de sectie Methodologie & Statistiek van het Instituut Psychologie aan de Universiteit Leiden

This thesis investigates opinion dynamics on random graphs through the lens of the voter model, a classical interacting particle system used to describe how consensus emerges in networks.

Promotor: Roeland M.H. Merks

Wetland plants are distinguished from plants of other terrestrial ecosystems by their adaptations to specific habitat stresses, including waterlogged and flooding and the subsequent abundance of phytotoxic compounds.

Interactive exploration of large volumes of data is increasingly common, as data scientists attempt to extract interesting information from large opaque data sets. This scenario presents a difficult challenge for traditional database systems, as (1) nothing is known about the query workload in advance,…

Drug induced organ toxicity is the main problem of the drug development and drug usage in the clinic. The liver and kidneys are the most sensitive organs towards drug induced toxicity.

Promotor: Prof.dr. P.G.L Klinkhamer, Co-promotor: K. Vrieling

The skin is our natural barrier and lipids are a key part of this barrier. In the outer skin layer, the stratum corneum (SC), lipids form a densely organized structure dependent on the composition of these lipids.

Promotor: Prof.dr. F.S. de Boer, Co-promotor: D. Clarke

Promotors: Prof.dr. T.H.W. Bäck, Prof.dr. B. Sendhoff (Technische Universität Darmstadt)

Promotor: Prof.dr. E.F. Smets. Co-promotores: B. Gravendeel, F. Pupulin

Due to their central physiological roles in living organisms, retaining beta-glycosidases have been the subject of tremendous research efforts to examine their structure/function relation using numerous biophysical and biochemical approaches.

Promotor: K.J. Batenburg, Co-promotor: A.W. van der Vaart, B. de Smit

Songbirds as vocal learners learn their songs and song preference from social tutors⁠. Tutor choice for both song and preference learning are important to characterize for understanding individual learning performance and cultural transmission of song⁠.

Promotores: Prof.dr. J.N. Kok, Prof.dr. C.A. Mandemakers, Co-Promotor: G. Bloothooft

Promotor: J.N. Kok, Co-Promotor: A.J. Knobbe

Synthesis and application of chemical biology tools to study immunomodulatory signaling lipids.

Promotores: T.H.W. Bäck, Y. Tan, Co-promotor: M.T.M. Emmerich

This thesis considers multi-prover commitment schemes whose security is based on restrictions on the communication between the provers.

This thesis seeks to combine two different research topics; Multi-Objective Optimization and Complex Network Analysis.

Optimization tasks in practice have multifaceted challenges as they are often black box, subject to multiple equality and inequality constraints and expensive to evaluate.

Promotor: Christoph U. Keller, Co-promotores: Matthew A. Kenworthy, Frans Snik

Self-assembly is an abundant process in nature and is vital to many processes in living organisms.

Promotor: M. Danhof, Co-promotor: E.C.M. de Lange

Promotor: Prof.dr. J.N. Kok, Co-promotor: A.J. Knobbe

Promotor: K.J. Batenburg

This thesis addresses the problem of designing performance and energy efficient embedded streaming systems, that is, systems which process a stream of input data coming from the environment and generate a stream of output data going into the environment.

This thesis describes the synthesis and biological evaluation of TLR2/6, TLR4, TLR7/8 and TLR9 ligands, of which the activity can be conditionally controlled.

This dissertation investigates the energy and material related impacts of the transition towards a low-carbon heating system in the Netherlands, in the context of its 2050 climate and circular economy policy goals.

Promotor: J.M. van Ruitenbeek, Co-Promotor: S.J. van der Molen

Autophagy is a fundamental degradative process, maintaining cellular homeostasis and functions in host defense against intracellular pathogens, including mycobacteria and Salmonella.