Anthropogenic noise negatively affects wildlife in a wide range of taxonomic groups.

Obesity may alter how a person absorbs, distributes, metabolizes or excretes medication. This thesis describes how obesity affects drug levels in the blood for antimicrobial agents, such as ciprofloxacin and fluconazole.

Promotor: J.M. van Ruitenbeek, Co-Promotor: S.J. van der Molen

As leading cause of death worldwide, cancer is responsible for nearly 10 million deaths in 2020 according to World Health Organization (WHO). Cisplatin and its derivatives are commonly used chemotherapy agents for current cancer treatment in the clinics.

This thesis aims to enhance our understanding of galaxies by testing theoretical models of galaxy formation against observations, particularly in the cases of extreme systems which have been found to have an excess of baryonic mass in their central regions, in the form of either supermassive black holes…

Despite the fact that gold nanoparticles (GNPs) are one of the most studied nanoparticles, there is still a necessity for new approaches allowing for effective protective coating to enable wider use of GNPs in biomedical applications.

At the moment, over 350.000 chemicals are registered worldwide for production and use. Their application, however, may harm human health and the environment.

Healthy aging is one of the prime goals in today's society and atherosclerosis is among the greatest causes of morbidity in elderly. Cardiovascular disease patients receiving treatment are often of advanced aged and have an aged immune system, which limits translating experimental findings to the pa…

Promotores: T.H.W. Bäck, Y. Tan, Co-promotor: M.T.M. Emmerich

Galaxy intrinsic alignments induce a major astrophysical contamination to weak gravitational lensing measurements and need to be modelled and mitigated when extracting cosmological information from such measurements.

Natural resources often stretch across borders that separate modern nation states. This can create conflict and limit opportunities for regulated consumption of their goods and services, but also provide opportunities for joint multinational efforts that exceed single country capabilities.

Hydrodesulfurization (HDS) is an ubiquitous part of oil refining that ensures that fuels are cleaned of impurities and environment release of pollutants such as SOx and NOx gasses are minimized.

In this thesis, we have studied the potential of the zebrafish larval model in studying the ECS, as a complementary model to the existing rodent models.

SDN (Software-Defined Networking) represents a revolutionary approach to network architecture that enables the dynamic and flexible management of network resources through software-based control. This dissertation introduces the idea of SDN and its southbound protocol OpenFlow, then presents the formal…

Promotor: M.L. van Hecke

In multi/many-core System-on-Chips (SoCs), the performance is almost linearly scaling with the number of processing elements.

Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: L.H. Heitman

Carbohydrates, or sugars, are the most diverse and most abundant biomolecules known. However, the isolation of carbohydrate samples in sufficient amounts and purity is often impractical or even impossible, so the chemical synthesis of glycosides becomes relevant. The glycosylation reaction, in which…

This thesis focuses on protoplanetary disks: flattened structures of gas and dust around young stars in which planets are expected to form and grow.

This thesis describes the use of a combined approach of computational and experimental techniques to gain novel insights to understand the glycosylation reaction and its reactive intermediates.

Promotor: K.J. Batenburg, Co-promotor: A.W. van der Vaart, B. de Smit

Promotors: Prof.dr. T.H.W. Bäck, Prof.dr. B. Sendhoff (Technische Universität Darmstadt)

The development of new environmentally sound technologies is seen as a key route towards achieving sustainability.

Science is typically a patchwork of research contributions without much coordination. Especially in clinical trials, the follow-up studies that we do fail to be the most promising.

It is a common technique in global optimization with expensive black-box functions to learn a surrogate-model of the response function from past evaluations and use it to decide on the location of future evaluations.

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Reconstructie van de taalgeschiedenis en prehistorie in de context van de Indo-Europese taalfamilie.

During the summer, we organize a summer school for researchers who want to learn about communicating science to diverse audiences. The summer school is aimed at researchers in any career stage who are new to science communication. The Summer School is open for all disciplines in science, including social…

Kidney transplantation is a major advance of modern medicine. This course will give you state of the art updates about what used to be an experimental, risky, and very limited treatment option more than 50 years ago and is now routinely performed in many countries worldwide.

Explore "Surgical anatomy of the leg in relation to nerve injuries" at Boerhaave Nascholing. Read more here.

Studievoorlichting

Studievoorlichting

Gezondheid is een groot goed. Zowel voor een mens als voor de maatschappij: met de preventie van ziekten, zowel lichamelijk als mentaal, kunnen we leed besparen en de stijgende gezondheidskosten bestrijden. Sociale wetenschappers en medici werken in Leiden nauw samen aan onderzoek naar de menselijke…

Luister naar de wetenschapspodcast van de Universiteit Leiden! In elke aflevering krijg je antwoord op jouw vragen over muggen, exoplaneten, Artificiële intelligentie, biologie en nog veel meer!

The findings in this thesis improve the understanding of 1) the relationship between exposure characteristics and toxicity of ENPs, 2) the joint toxic action of ENP mixtures and the comparison to metal salt mixtures, 3) how NOM affects the individual and joint toxicity of ENPs, 4) the extent of trophic…

What are the pressing issues of our time, and how can different disciplines come together to address them? Studium Generale and Leiden University College (LUC) present the Global Challenges series: events that bring together researchers from LUC and experts from other disciplines to tackle a shared…

Dit boek neemt je stapsgewijs mee in het schrijven van een scriptie, met (voornamelijk) een focus op experimenteel onderzoek, dat het meest veel voorkomt. Door de stappen van experimenteel onderzoek in chronologische volgorde op te splitsen en bij elke stap tips te geven, hopen de auteurs enig houvast…

Discover the master program population Health Management at Leiden University and contribute to a more integrated health care system. Learn more!

Public Administration is a major refereed journal publishing articles on public administration, public policy and public management.

Promotores: J. Kok, M. Chaudron (Chalmers University)

Promotor: Prof.dr. M. Schilthuizen

Promotores: H.W. Lenstra, K. Belabas (University of Bordeaux)

This thesis aimed to investigate the impact of exposure dynamics, relative contributions of ENPs(particle) and ENPs(ion), and dosing regimens on the toxicity of ENPs varying in different physico-chemical properties, on the composition and functioning of soil microbial communities.

The present thesis focuses on the pharmacological concept of drug-target interaction, which dates back to the beginning of modern pharmacology.

This dissertation explores how we can make anomaly detection—identifying unusual or faulty behavior in complex systems—more trustworthy and effective, with a focus on smart manufacturing.

Tuberculosis is a major global health problem caused by the Mycobacterium tuberculosis complex, claiming more than a million lives annually.

Promotores: A.P. IJzerman, H.W.T. van Vlijmen