Promotor: Prof.dr.ir. J.W.M. Hilgenkamp, Prof.dr. J. van den Brink

In this dissertation, we work towards an experiment in which we aim to bring a micrometer sized magnet at the tip of a soft cantilever into a superposition.

Promotores: R. Cramer, A.K. Lenstra, Co-Promotor: B.M.M. de Weger

This dissertation contains four works during my PhD. Different biomaterials have been designed based on coiled-coil peptides. These biomaterials have a range of applications, inclusing drug delivery, cell sorting to cell-cell fusion.

Advanced sensing techniques require graphene with high quality and well-controlled surface chemistry.

Ice, the solid state of water, plays an important role on our planet as well as the entire universe.Despite the fact that an individual water molecule has a very simple structure, its chemical bonding in the solid phase can be surprisingly complex.

Promotor: E. Bouwman, Co-Promotor: S. Bonnet

Self-assembly is an abundant process in nature and is vital to many processes in living organisms.

We use DNA strands to stabilize few-atom silver clusters, which show unique optical and chemical properties. This thesis involves the study of these constructs for various applications.

This thesis describes the design, characterization and application of dextran based crosslinked network.

Promotor: Prof.dr. D. Bouwmeester, Co-Promotor: M.J.A. de Dood

The thesis introduces three methods for high-dimensional prediction problems in the biomedical field. The methods make use of empirical and variational Bayes in the estimation.

This thesis focuses on addressing four research problems in designing embedded streaming systems.

Promotor: M.A.G.J. Orrit

This thesis explores squaramide-based supramolecular polymers and hydrogels, enhancing their mechanical strength for 3D cell culture.

Quantum critical metals at vanishing fermion flavor number.

Carbohydrates, alongside proteins and nucleic acids, constitute a crucial and versatile family of biomolecules present in all life forms. They manifest as monosaccharides, oligosaccharides, and polysaccharides, covalently bonded to proteins and fats. Carbohydrates are integral to plant and arthropod…

This work has described synthetic strategies towards well-defined structures resembling capsular polysaccharide (CPS) fragments, CPS mimics, teichoic acid (TA) fragments as well as a third-generation ring-closing tandem metathesis (RCM) linker to better exploit the potential of automated synthesis.

Despite the fact that gold nanoparticles (GNPs) are one of the most studied nanoparticles, there is still a necessity for new approaches allowing for effective protective coating to enable wider use of GNPs in biomedical applications.

In this thesis we will explore the use of fuzzy systems theory for applications in bioinformatics.

In this work we describe three methods to improve the performance of Quantum Field Theory calculations.

Promotor: Prof.dr. M.A.G.J. Orrit

We find ourselves in an era of transition, not just towards a more computing- and data-driven society but also away from unsustainable fossil fuels as an energy source.

What physics controls the properties of quantum matter, such as how electrons flow inside high-temperature superconductors? This question has captivated the physics community and industry for decades, in part due to the great technological potential such materials have, but also because they have resisted…

De LUCDH financiert de ontwikkeling van onderzoeksactiviteiten, kennis en vaardigheden op het gebied van digitale geesteswetenschappen en AI via een programma voor kleine subsidies.

This thesis has three main parts. The first part gives an algorithm to compute Hilbert modular polynomials for ordinary abelian varieties with maximal real multiplication. Hilbert modular polynomials of a given level b give a way of finding all of the abelian varieties that are b-isogeneous to any given…

A Josephson junction is a device where a thin insulating barrier or a nanostructure is placed between two superconducting leads. Such a junction is essential to superconducting qubits that store quantum information due to its anharmonic spectrum.

Promotor: S.J. Edixhoven, Co-promotor: R.S. de Jong

Explore how to apply for the MSc Democracy and Representation at Leiden University: follow the step-by-step application guide, including admission requirements, deadlines, required documents, and next steps.

Surface acoustic waves (SAWs) are mechanical waves that travel along the surface of a material and find many applications in modern technologies due to the ease of excitation on piezoelectric substrates via interdigital transducers (IDTs).

This thesis is a collection of experimental attempts to enhance photoluminescence of fluorescent molecules and quantum dots with single gold nanorods (GNRs) and relevant applications.

Promotor: A. Kros

This thesis addresses the problem of designing performance and energy efficient embedded streaming systems, that is, systems which process a stream of input data coming from the environment and generate a stream of output data going into the environment.

The recently introduced nature-originated deep eutectic solvents, so-called natural deep eutectic solvents (NADES) are considered as truly green solvents, which composed of natural ingredients found abundantly in organisms.

Kunnen we bewijzen of een groot quantumsysteem zich echt gedraagt volgens de vreemde regels van de quantummechanica – of alleen maar doet alsof? Een team van natuurkundigen van de Universiteit Leiden en uit China vond in een baanbrekende studie het antwoord op deze vraag.

In het Leids Universitaire weekblad “Mare” is onlangs een interview verschenen met de Leidse statisticus prof. dr. Richard Gill over zijn bijdrage aan het Delftse quantum-experiment.

This thesis consists of five chapters on how to construct prediction sets for different types of data and models in a parametric or nonparametric Bayesian paradigm.

Quantumsoftware is essentieel om quantumtechnologie te laten werken. De onderzoekscentra QuSoft en aQa werken samen aan de frontlinie van het Nederlandse onderzoek naar quantumsoftware. Met de lancering van de Quantum Software Alliance (QSA) schaalt deze samenwerking nu wereldwijd op.

Wat is quantum nou eigenlijk? Tja, probeer dat maar eens in begrijpelijke taal uit te leggen. In diverse regionale kranten doet wiskundige Peter Bruin een poging. ‘Om quantum te begrijpen, moet je tegen je intuïtie in denken. Daar is ons brein niet voor gemaakt.’

Gold nanorods are biocompatible nanoparticles that present an excellent two-photon signal that can be used to get high spatial resolution inside living cells. Gold nanorods are photostable and therefore can be followed inside cells for long time, with possible applications as trackers in live cells.

Carbohydrates are present on the surface of bacteria making them suitable antigen candidates for vaccine development. This thesis deals with the synthesis of two carbohydrate-based components; the capsular polisaccharide of S. aureus type 5 and teichoic acids from staphilococci and enterococci speci…

An objective of this research was to achieve direct, well-defined and non-rate-limiting electron transfer between respiratory enzymes and the electrode surface by means of 'Q-wires'.

This thesis describes biochemical investigations of glucocerebrosidase (GBA), the lysosomal β- glucosidase that is deficient in Gaucher disease (GD).

Growth hormone profiles are pulsatile and highly variable between individuals, limiting the implementation of mathemathical models to quantify an individual's secretion.

Promotor: Prof.dr. M. Danhof, Co-Promotor: J. de Jongh

In this thesis I highlight the applications of Oxford Nanopore Technologies (ONT) sequencing. This technique is a relatively new approach in the sequencing field, where nanopores are embedded in a membrane, DNA molecules are pulled through nanopores and an electrical current serving as the sequencing…

Lysosomal glycosidases are acid hydrolases that fragment glycoconjugates in lysosomes.

Promotor: S.M. Verduyn Lunel, Co-Promotor: O.W. van Gaans